Mechanism-based inactivation of α-chymotrypsin

Syntheses ofgem-Dihalocyclopropanes and Their Use in Organic Synthesis

“…Their photolysis yields dichlorocarbene, which can be captured by alkenes (eq 5). 40,41 Other recently described methods, such as (a) the lithiation of diethyl trichloromethyl phosphonate in the presence of an alkene, 42 (b) the decomposition of trimethylsilyl trichloroacetate under the influence of potassium fluoride in the presence of a quat or crown ether, 43 (c) the use of alumina impregnated with potassium fluoride as a base for R-elimination in the presence of a quat as a catalyst, 44 (d) the reaction of chloroform and magnesium with alkenes, 45 (e) the reaction of carbon tetrachloride with reduced titanium in the presence of alkenes, 46 and (f) the reaction of chloroform with butyllithium in the presence of alkenes, 47 do not offer advantages over the methods presented earlier, and have not found practical application in recent years, or have been only rarely used.…”