Mechanism-based inactivation of serine proteases by dichlorocyclopropane fused lactone derivatives

Syntheses ofgem-Dihalocyclopropanes and Their Use in Organic Synthesis

“…153 Ketone-derived enol esters add dichlorocarbene exclusively, often in high yields. 153,155 Selected ex- amples of gem-dichlorocyclopropanes formation from alkenes substituted by two (or more) different functional groups [156][157][158][159][160][161][162][163][164][165][166][167] are presented in Table 4.…”