Mechanism and therapeutic effect of umbilical cord mesenchymal stem cells in inflammatory bowel disease

Pan, Xinghua; Li, Qing; Zhu, Xiaoyan; Li, Zi-an; Cai, Xue-Min; Pang, Rong-Qing; Ruan, Guo‐Rui

doi:10.1038/s41598-019-54194-y

Cited by 13 publications

(5 citation statements)

References 41 publications

(41 reference statements)

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“…Despite the poor prospects of HSCT for the treatment of IBD, IBD patients with IL-10 gene defects seem to be cured by allogeneic transplantation [ 60 ]. The MSCT can repair damaged intestinal tissues by reducing the development of intestinal inflammation in IBD patients and by improving local microcirculation in the intestine [ 61 ]. Apart from a transient fever and a minimal risk of tumorigenesis, MSCT has not shown any other significant side effects.…”

Section: Pathogenesis Of Ibd and Current Therapeutic Agentsmentioning

confidence: 99%

Treatment Effects of Natural Products on Inflammatory Bowel Disease In Vivo and Their Mechanisms: Based on Animal Experiments

2023

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Inflammatory bowel disease (IBD) is a chronic, non-specific inflammatory disease of the intestine that can be classified as ulcerative colitis (UC) and Crohn’s disease (CD). Currently, the incidence of IBD is still increasing in developing countries. However, current treatments for IBD have limitations and do not fully meet the needs of patients. There is a growing demand for new, safe, and highly effective alternative drugs for IBD patients. Natural products (NPs) are used in drug development and disease treatment because of their broad biological activity, low toxicity, and low side effects. Numerous studies have shown that some NPs have strong therapeutic effects on IBD. In this paper, we first reviewed the pathogenesis of IBD as well as current therapeutic approaches and drugs. Further, we summarized the therapeutic effects of 170 different sources of NPs on IBD and generalized their modes of action and therapeutic effects. Finally, we analyzed the potential mechanisms of NPs for the treatment of IBD. The aim of our review is to provide a systematic and credible summary, thus supporting the research on NPs for the treatment of IBD and providing a theoretical basis for the development and application of NPs in drugs and functional foods.

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Section: Pathogenesis Of Ibd and Current Therapeutic Agentsmentioning

confidence: 99%

Treatment Effects of Natural Products on Inflammatory Bowel Disease In Vivo and Their Mechanisms: Based on Animal Experiments

2023

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“…The study of MSCs in IBD has been extensively explored, where MSCs actively ease IBD. For example, umbilical cord MSCs (ucMSCs) are commonly used in disease treatment and their transplantation (from Kunming mice and humans) can effectively protect mice from intestinal injury (152). In addition, ucMSCs can also attenuate colitis through regulating immune cells and associated cytokines.…”

Section: Characteristics Of Mscsmentioning

confidence: 99%

Intestinal Fibrosis in Inflammatory Bowel Disease and the Prospects of Mesenchymal Stem Cell Therapy

et al. 2022

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Intestinal fibrosis is an important complication of inflammatory bowel disease (IBD). In the course of the development of fibrosis, certain parts of the intestine become narrowed, significantly destroying the structure and function of the intestine and affecting the quality of life of patients. Chronic inflammation is an important initiating factor of fibrosis. Unfortunately, the existing anti-inflammatory drugs cannot effectively prevent and alleviate fibrosis, and there is no effective anti-fibrotic drug, which makes surgical treatment the mainstream treatment for intestinal fibrosis and stenosis. Mesenchymal stem cells (MSCs) are capable of tissue regeneration and repair through their self-differentiation, secretion of cytokines, and secretion of extracellular vesicles. MSCs have been shown to play an important therapeutic role in the fibrosis of many organs. However, the role of MSC in intestinal fibrosis largely remained unexplored. This review summarizes the mechanism of intestinal fibrosis, including the role of immune cells, TGF-β, and the gut microbiome and metabolites. Available treatment options for fibrosis, particularly, MSCs are also discussed.

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“…Mesenchymal stem cell treatment of IBD has been studied in many preclinical studies trials in animal models of IBD. When MSCs are injected intravenously, they can reach the site of intestinal injury and colonize the intestinal mucosa to control the development of inflammation locally, improve local microcirculation, and repair damaged tissues [ 117 ]. Studies have shown that MSC treatment of IBD is mainly carried out through local microcirculation construction, colonization and repair, and immunomodulation ( Table 3 ).…”

Section: Stem Cell Therapy For Ibdmentioning

confidence: 99%

Stem Cell-Based Therapies for Inflammatory Bowel Disease

Zhang

Yuan

Meng

et al. 2022

IJMS

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Inflammatory bowel disease (IBD) is a chronic, relapsing disease that severely affects patients’ quality of life. The exact cause of IBD is uncertain, but current studies suggest that abnormal activation of the immune system, genetic susceptibility, and altered intestinal flora due to mucosal barrier defects may play an essential role in the pathogenesis of IBD. Unfortunately, IBD is currently difficult to be wholly cured. Thus, more treatment options are needed for different patients. Stem cell therapy, mainly including hematopoietic stem cell therapy and mesenchymal stem cell therapy, has shown the potential to improve the clinical disease activity of patients when conventional treatments are not effective. Stem cell therapy, an emerging therapy for IBD, can alleviate mucosal inflammation through mechanisms such as immunomodulation and colonization repair. Clinical studies have confirmed the effectiveness of stem cell transplantation in refractory IBD and the ability to maintain long-term remission in some patients. However, stem cell therapy is still in the research stage, and its safety and long-term efficacy remain to be further evaluated. This article reviews the upcoming stem cell transplantation methods for clinical application and the results of ongoing clinical trials to provide ideas for the clinical use of stem cell transplantation as a potential treatment for IBD.

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Mechanism and therapeutic effect of umbilical cord mesenchymal stem cells in inflammatory bowel disease

Cited by 13 publications

References 41 publications

Treatment Effects of Natural Products on Inflammatory Bowel Disease In Vivo and Their Mechanisms: Based on Animal Experiments

Treatment Effects of Natural Products on Inflammatory Bowel Disease In Vivo and Their Mechanisms: Based on Animal Experiments

Intestinal Fibrosis in Inflammatory Bowel Disease and the Prospects of Mesenchymal Stem Cell Therapy

Stem Cell-Based Therapies for Inflammatory Bowel Disease

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