Stem Cell-Based Therapies for Inflammatory Bowel Disease

Zhang, Huamin; Yuan, Shi‐Min; Meng, Huan; Hou, Xiao-Ting; Li, Jiao; Xue, Jia-Chen; Li, You; Wang, Qi; Nan, Ji‐Xing; Jin, Xuejun; Zhang, Qinggao

doi:10.3390/ijms23158494

Cited by 22 publications

(14 citation statements)

References 159 publications

(155 reference statements)

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“…The utility of stem cell technology for the repair and regeneration of the injured intestine has been a major focus, and stem cell-based regenerative therapies hold promise for anastomotic healing (Flatres et al, 2019;Lightner, 2019;Kent et al, 2021;Zhang et al, 2022). In fact, studies have reported the utilization of stem cell patches in animal experiments to promote anastomotic healing with positive outcomes (Maruya et al, 2017;Van de Putte et al, 2017;Sukho et al, 2018;Morgan et al, 2020;Pan et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…Stem cell-based regenerative therapies are considered a promising scheme as stem cells have the ability to differentiate into intestinal cells or promote intestinal cell proliferation (Flatres et al, 2019;Lightner, 2019;Kent et al, 2021;Zhang et al, 2022). Several preclinical studies investigated the role of stem cell transplantation in accelerating the healing of intestinal anastomosis, and preliminary results indicated that stem cell transplantation has the potential to protect surgical anastomosis (Maruya et al, 2017;Van de Putte et al, 2017;Sukho et al, 2018;Morgan et al, 2020;Pan et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Mesenchymal stem cell secretome-loaded fibrin glue improves the healing of intestinal anastomosis

Zhou

Feng

et al. 2023

Front. Bioeng. Biotechnol.

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Anastomotic leakage is a serious complication following gastrointestinal surgery and one of the leading causes of patient mortality. Despite the significant clinical and economic burden, there are currently no reliable treatment options to improve the healing of intestinal anastomosis and subsequently prevent anastomotic leakage. Recently, the development of regenerative medicine has shown promise for improving anastomotic healing. Recent studies have illustrated that stem cell-derived secretome can enhance tissue regeneration without the safety and ethical limitations of stem cell transplantation. Herein, we developed a fibrin glue topical delivery system loaded with mesenchymal stem cells (MSCs)-derived secretome for controlled delivery of bioactive factors, and evaluated its application potential in improving the healing of intestinal anastomosis. Under in vitro conditions, the MSCs secretome significantly promoted cell proliferation viability in a dose-dependent manner and resulted in the controlled release of growth factors via fibrin glue delivery. We established a rat surgical anastomotic model and experimentally found that MSCs secretome-loaded fibrin glue enhanced anastomotic bursting pressure, increased granulation tissue formation and collagen deposition, and significantly promoted anastomotic healing. Mechanistically, fibrin glue accelerated cell proliferation, angiogenesis, and macrophage M2 polarization at the surgical anastomotic site by releasing bioactive factors in the secretome, and it also alleviated the inflammatory response and cell apoptosis at the anastomotic site. Our results demonstrated for the first time that MSCs-derived secretome could promote the healing of intestinal anastomosis. Considering the accessibility and safety of the cell-free secretome, we believed that secretome-loaded fibrin glue would be a cell-free therapy to accelerate the healing of intestinal anastomosis with great potential for clinical translation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mesenchymal stem cell secretome-loaded fibrin glue improves the healing of intestinal anastomosis

Zhou

Feng

et al. 2023

Front. Bioeng. Biotechnol.

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“…Stem cell transplantation therapy appears to be used to improve clinical symptoms in patients with IBD when conventional therapies are ineffective, or even ineffective in the treatment of IBD. Stem cell transplantation therapy can be divided into hematopoietic stem cell transplantation (HSCT) and mesenchymal stem cell transplantation (MSCT) [ 59 ]. HSCT can be divided into autogenous and allogeneic transplantation.…”

Section: Pathogenesis Of Ibd and Current Therapeutic Agentsmentioning

confidence: 99%

“…Therefore, it is considered as a safer treatment [ 63 ]. Stem cell transplantation is a relatively new method of treating IBD, and more research is required to determine its safety and therapeutic effectiveness [ 59 ]. Therefore, stem cell transplantation is not yet a mainstream method used to treat IBD.…”

Section: Pathogenesis Of Ibd and Current Therapeutic Agentsmentioning

confidence: 99%

Treatment Effects of Natural Products on Inflammatory Bowel Disease In Vivo and Their Mechanisms: Based on Animal Experiments

2023

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Inflammatory bowel disease (IBD) is a chronic, non-specific inflammatory disease of the intestine that can be classified as ulcerative colitis (UC) and Crohn’s disease (CD). Currently, the incidence of IBD is still increasing in developing countries. However, current treatments for IBD have limitations and do not fully meet the needs of patients. There is a growing demand for new, safe, and highly effective alternative drugs for IBD patients. Natural products (NPs) are used in drug development and disease treatment because of their broad biological activity, low toxicity, and low side effects. Numerous studies have shown that some NPs have strong therapeutic effects on IBD. In this paper, we first reviewed the pathogenesis of IBD as well as current therapeutic approaches and drugs. Further, we summarized the therapeutic effects of 170 different sources of NPs on IBD and generalized their modes of action and therapeutic effects. Finally, we analyzed the potential mechanisms of NPs for the treatment of IBD. The aim of our review is to provide a systematic and credible summary, thus supporting the research on NPs for the treatment of IBD and providing a theoretical basis for the development and application of NPs in drugs and functional foods.

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“…In addition to the above therapeutic mechanisms, stem cells have received more and more attention as an effective therapeutic tool with intrinsic repair ability toward IBD treatment either with or without nanomaterial loads. [ 147 ] Plenty of studies have shown that different types of stems cells including hematopoietic stem cells (HSC), mesenchymal stem cells (MSC), and intestinal epithelial stem cells can improve intestinal lesions by immunomodulation and tissue repair after homing to the inflamed intestine. Despite stem cell‐related IBD therapy still being in its fancy, it has shown huge potential in alleviating mucosal inflammation, which results in the clinical remission of IBD.…”

Section: Advanced Nanomedicines Treat Ibd Through Different Therapeut...mentioning

confidence: 99%

Advanced Nanomedicine: Redefining Therapeutic Paradigms for Inflammatory Bowel Disease

Zhang

Wang

Sun

et al. 2023

Adv Healthcare Materials

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Inflammatory bowel disease (IBD), a chronic and recurrent gastrointestinal inflammatory disorder with a variety of painful clinical manifestations and an increased risk of cancerization or death, has become an emerging challenge to global healthcare due to its rapidly increasing incidence. At present, there is no efficient cure against IBD because of the elusive etiology and pathogenesis of IBD. Therefore, the development of alternative therapeutic strategies with positive clinical efficacy and reduced side effects is urgently needed. In recent years, the great prosperity of nanomedicine promoted by a variety of advanced nanomaterials is redefining more attractive and promising therapeutic strategies for IBD owing to their advantages in the physiological stability, bioavailability, and targeting of inflammatory sites. In this review, firstly the basic characteristics of healthy and inflammatory intestinal microenvironments are presented. Then, different administration routes and targeting strategies of nanotherapeutics for IBD treatment are reviewed. Subsequently, a specific focus is placed on the introduction of nanotherapeutic treatments based on different IBD pathogenesis. Finally, some future challenges and perspectives of the currently developed nanomedicines for IBD treatment are provided. It is believed that the above topics will attract researchers from various fields including medicine, biological sciences, materials, chemistry and pharmaceutics.

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Stem Cell-Based Therapies for Inflammatory Bowel Disease

Cited by 22 publications

References 159 publications

Mesenchymal stem cell secretome-loaded fibrin glue improves the healing of intestinal anastomosis

Mesenchymal stem cell secretome-loaded fibrin glue improves the healing of intestinal anastomosis

Treatment Effects of Natural Products on Inflammatory Bowel Disease In Vivo and Their Mechanisms: Based on Animal Experiments

Advanced Nanomedicine: Redefining Therapeutic Paradigms for Inflammatory Bowel Disease

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