Mechanism and intervention measures of iron side effects on the intestine

Xiao, Qi; Zhang, Yuanxiao; Guo, Huicai; Yu, Hai; Luo, Yane; Yue, Tianli

doi:10.1080/10408398.2019.1630599

Cited by 79 publications

(68 citation statements)

References 113 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although very high lipid levels can reduce embryo freezing efficiency, lipids are an important source of energy for embryos, playing a key role in embryonic development (Amstislavsky et al, 2019 ). It has been reported that abnormal metabolism of lipids can cause cell apoptosis and necrosis (Qi et al, 2019 ). Dos Santos et al ( 2019 ) found that saffron can enhance the in vitro development of bovine embryos by increasing lipid metabolism levels.…”

Section: Discussionmentioning

confidence: 99%

Single-Cell Transcriptome Profiling Revealed That Vitrification of Somatic Cloned Porcine Blastocysts Causes Substantial Perturbations in Gene Expression

Zhang

Wei

et al. 2020

Front. Genet.

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Single-Cell Transcriptome Profiling Revealed That Vitrification of Somatic Cloned Porcine Blastocysts Causes Substantial Perturbations in Gene Expression

Zhang

Wei

et al. 2020

Front. Genet.

View full text Add to dashboard Cite

“…During SAP, the integrity of intestinal epithelial barrier is destroyed, resulting in BT and a series of complications [ 8 ]. Recent studies have shown that initiation of lipid peroxidation and destruction of the dynamic balance of oxygen free radicals can lead to the ferroptosis of IECs [ 26 ]. Thus, we established a rat SAP model to explore the role of ferroptosis in SAP-induced intestinal barrier dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Effects of Lipid Peroxidation‐Mediated Ferroptosis on Severe Acute Pancreatitis‐Induced Intestinal Barrier Injury and Bacterial Translocation

Jiang

et al. 2021

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Ferroptosis is a recently recognized type of regulated cell death characterized by iron- and lipid peroxidation-mediated nonapoptotic cell death. However, whether ferroptosis is involved in severe acute pancreatitis- (SAP-) induced intestinal barrier injury is unknown. The aim of this study was to investigate whether ferroptosis is involved in SAP-induced intestinal barrier injury, particularly intestinal epithelial cell (IEC) death, and determine whether the inhibition of ferroptosis would ameliorate intestinal barrier injury and prevent bacterial translocation (BT). Sodium taurocholate (5%) was retrogradely perfused into the biliopancreatic duct to establish a rat model of SAP. The rats were divided into three groups: sham operation (SO), SAP-induced intestinal barrier injury (SAP), and ferroptosis inhibitor liproxstatin-1 ( SAP + Lip ). Serum indexes were measured in the rats. In addition, the biochemical and morphological changes associated with ferroptosis were observed, including iron accumulation in intestinal tissue, lipid peroxidation levels, and mitochondrial shrinkage. Hematoxylin staining and eosin staining were used to assess histological tissue changes. Western blot, RT-PCR, and immunofluorescent staining were performed to analyze the expression of ferroptosis-related proteins and genes as well as tight junction. BT was detected by 16S rDNA sequencing analysis. The results indicated that ferroptosis was significantly induced in the IECs from rats with SAP and ferroptosis was mediated by lipid peroxidation. The specific lipid peroxidation of IECs clearly upregulated ferroptosis and exacerbated intestinal barrier injury. Furthermore, treatment with liproxstatin-1 lowered the levels of serum damage markers, decreased lipid peroxidation, and alleviated intestinal and acute remote organ injury in SAP rats. In addition, inhibition of ferroptosis reduced BT. Our findings are the first to demonstrate that ferroptosis contributes to SAP-induced intestinal barrier injury via lipid peroxidation-mediated IEC death. These results suggest that ferroptosis is a potential therapeutic target for SAP-induced intestinal barrier injury.

show abstract

“…The data that were collected and interrogated raised some interesting issues. The comparison between a high‐dose (6 mg/kg/dose) and low‐dose (2 mg/kg/dose) supplemental iron regimen, along with the nonassociation between duration of iron therapy and RBC transfusion, may highlight the difficulty with compliance to supplemental iron therapy given its noted gastrointestinal side effect profile 20 . This may raise the potential of treatment fatigue, in that patients are initially compliant, but as the treatment duration is prolonged, and surgery approaches, compliance falls.…”

Section: Discussionmentioning

confidence: 99%

Association between preoperative hemoglobin levels after iron supplementation and perioperative blood transfusion requirements in children undergoing scoliosis surgery

Switzer

Naraine

Chamlati

et al. 2020

Pediatric Anesthesia

View full text Add to dashboard Cite

Background and Aims: In this study, we assessed the association between preoperative hemoglobin and red blood cell transfusion in children undergoing spine surgery after the implementation of our preoperative iron supplementation protocol. Method: We performed a retrospective analysis of patients who underwent posterior spinal fusion surgery between January 2013 and December 2017 and received preoperative iron supplementation. We used uni-and multivariable logistic regression to determine the association between preoperative hemoglobin level and red blood cell transfusion in patients receiving iron supplementation. Results: A total of 382 patients treated with preoperative oral iron were included. Of these, 175 (45.5%) patients were transfused intraoperatively. Multivariable logistic regression analysis revealed nonidiopathic etiology of the scoliosis (OR 4.178

show abstract

Mechanism and intervention measures of iron side effects on the intestine

Cited by 79 publications

References 113 publications

Single-Cell Transcriptome Profiling Revealed That Vitrification of Somatic Cloned Porcine Blastocysts Causes Substantial Perturbations in Gene Expression

Single-Cell Transcriptome Profiling Revealed That Vitrification of Somatic Cloned Porcine Blastocysts Causes Substantial Perturbations in Gene Expression

Effects of Lipid Peroxidation‐Mediated Ferroptosis on Severe Acute Pancreatitis‐Induced Intestinal Barrier Injury and Bacterial Translocation

Association between preoperative hemoglobin levels after iron supplementation and perioperative blood transfusion requirements in children undergoing scoliosis surgery

Contact Info

Product

Resources

About