Mechanism and Inhibition of the β‐Class and γ‐Class Carbonic Anhydrases

(In)organic anions as carbonic anhydrase inhibitors

“…6). Indeed, in the case of the γ-CA from the archaeon Methanosarcina thermophila, Ferry's group observed that the Zn(II) ion may easily be substituted by Co(II) or Fe(II), with the enzyme maintaining a good catalytic activity [13,[81][82][83][84]. This is why several X-ray structures of adducts of both Zn-and Co-containing Cam with anions such as bicarbonate and sulfate have been resolved and shown schematically in Fig.…”

“…The β-CA class is the most widespread one in nature, such enzymes being found in archaea, bacteria, fungi, plants and even arthropodes [8,9,[81][82][83][84][85][86][87][88]. γ-CAs were described on the other hand only in Archaea for the moment [13,83,84,86].…”

“…γ-CAs were described on the other hand only in Archaea for the moment [13,83,84,86]. The β-class enzymes are usually homodimers, possessing two identical active sites, which have the shape of long channels at the bottom of which is found the catalytic zinc ion.…”