(In)organic anions as carbonic anhydrase inhibitors

Structure-based drug discovery of carbonic anhydrase inhibitors

“…discuss some carboxylates as fungal β-CAIs since the COO − ZBG was less investigated in the drug design of CAIs till recently 11,71 . Both aliphatic and aromatic carboxylates were investigated as inhibitors of α-and β-CAs in the recent period 11,71 .…”

In vitroandin vivoantitumor activity of the halogenated boroxine dipotassium-trioxohydroxytetrafluorotriborate (K2[B3O3F4OH])

“…This intensive area of medicinal chemistry research has recently culminated in the commercialization of the peptidylboronic acid antineoplastic drug Velcade [3][4][5] . Some boron-containing anions were observed as inhibitors of enzyme human carbonic anhydrase [6][7][8] . Recently, it has been suggested that halogenated boroxines K 2 [B 3 O 3 F 4 OH] can be used in the prevention and/or treatment of benign or malignant changes of the epidermis visible in the form of, for example, nevus or skin cancer 9,10 .…”

Synthesis and biological evaluation of cyclic imides incorporating benzenesulfonamide moieties as carbonic anhydrase I, II, IV and IX inhibitors

“…18 Phenol Red (at a concentration of 0.2 mM) has been used as indicator, working at the absorbance maximum of 557 nm, with 10 mM Hepes (pH 7.4) as buffer, 0.1 M Na 2 SO 4 or NaClO 4 (for maintaining constant the ionic strength; these anions are not inhibitory in the used concentration), 22 following the CAcatalyzed CO 2 hydration reaction for a period of 5-10 s. Saturated CO 2 solutions in water at 25°C were used as substrate. Stock solutions of inhibitors were prepared at a concentration of 10 mM (in DMSO-water 1:1, v/v) and dilutions up to 0.01 nM done with the assay buffer mentioned above.…”