Mechanism and application of 3D-printed degradable bioceramic scaffolds for bone repair

Lin, Hui; Zhang, Liyun; Zhang, Qiyue; Wang, Qiang; Wang, Xue; Yan, Guangqi

doi:10.1039/d3bm01214j

Cited by 5 publications

(3 citation statements)

References 222 publications

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“…Boron-containing BG (bioactive glass) scaffolds enhance osteogenesis via transcription factor 7-like 2 and mediate the upregulation of lipocalin-2. Overall, activating the Wnt/β-catenin pathway promotes osteogenic differentiation, offering therapeutic potential in bone regeneration [76].…”

Section: The Signaling Pathway Of Wingless/integrated (Wnt)/β-cateninmentioning

confidence: 99%

The Role of Bioceramics for Bone Regeneration: History, Mechanisms, and Future Perspectives

Tanvir,

Khaleque,

Kim

et al. 2024

Biomimetics

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Osteoporosis is a skeletal disorder marked by compromised bone integrity, predisposing individuals, particularly older adults and postmenopausal women, to fractures. The advent of bioceramics for bone regeneration has opened up auspicious pathways for addressing osteoporosis. Research indicates that bioceramics can help bones grow back by activating bone morphogenetic protein (BMP), mitogen-activated protein kinase (MAPK), and wingless/integrated (Wnt)/β-catenin pathways in the body when combined with stem cells, drugs, and other supports. Still, bioceramics have some problems, such as not being flexible enough and prone to breaking, as well as difficulties in growing stem cells and discovering suitable supports for different bone types. While there have been improvements in making bioceramics better for healing bones, it is important to keep looking for new ideas from different areas of medicine to make them even better. By conducting a thorough scrutiny of the pivotal role bioceramics play in facilitating bone regeneration, this review aspires to propel forward the rapidly burgeoning domain of scientific exploration. In the end, this appreciation will contribute to the development of novel bioceramics that enhance bone regrowth and offer patients with bone disorders alternative treatments.

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Section: The Signaling Pathway Of Wingless/integrated (Wnt)/β-cateninmentioning

confidence: 99%

The Role of Bioceramics for Bone Regeneration: History, Mechanisms, and Future Perspectives

Tanvir,

Khaleque,

Kim

et al. 2024

Biomimetics

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“…The formation of the HA layer may decrease the rate of implant resorption and decrease its solubility[ 17 ]. Recently this obstacle has been resolved by constructing of implants via 3D printing technology[ 21 ]. Another significant impediment is bacterial infection transmission after-surgical implantation.…”

Section: Bioceramics In Hard Tissue Regenerationmentioning

confidence: 99%

Advances in clinical applications of bioceramics in the new regenerative medicine era

Elshazly,

Nasr,

Hamdy

et al. 2024

World J Clin Cases

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In this editorial, we comment on the hard and soft tissue applications of different ceramic-based scaffolds prepared by different mechanisms such as 3D printing, sol-gel, and electrospinning. The new concept of regenerative medicine relies on biomaterials that can trigger in situ tissue regeneration and stem cell recruitment at the defect site. A large percentage of these biomaterials is ceramic-based as they provide the essential requirements of biomaterial principles such as tailored multisize porosity, antibacterial properties, and angiogenic properties. All these previously mentioned properties put bioceramics on top of the hierarchy of biomaterials utilized to stimulate tissue regeneration in soft and hard tissue wounds. Multiple clinical applications registered the use of these materials in triggering soft tissue regeneration in healthy and diabetic patients such as bioactive glass nanofibers. The results were promising and opened new frontiers for utilizing these materials on a larger scale. The same results were mentioned when using different forms and formulas of bioceramics in hard defect regeneration. Some bioceramics were used in combination with other polymers and biological scaffolds to improve their regenerative and mechanical properties. All this progress will enable a larger scale of patients to receive such services with ease and decrease the financial burden on the government.

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“…Magnesium (Mg)-based materials could be candidate materials for addition to conduits or to provide physical contact guidance inside a conduit. Mg implants are being used at the clinical level in orthopedic, dental, and cardiovascular applications, for both the mechanical properties of the Mg metal and the biological and the anti-inflammatory effects of the released Mg ions [6][7][8]. Nervous tissue and neurological applications have focused more on the biological rather than the mechanical properties, as only minimal strength is required for these applications [9,10].…”

Section: Introductionmentioning

confidence: 99%

Influence of Magnesium Degradation on Schwannoma Cell Responses to Nerve Injury Using an In Vitro Injury Model

Bhat,

Hanke,

Helmholz

et al. 2024

JFB

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Nerve guidance conduits for peripheral nerve injuries can be improved using bioactive materials such as magnesium (Mg) and its alloys, which could provide both structural and trophic support. Therefore, we investigated whether exposure to Mg and Mg-1.6wt%Li thin films (Mg/Mg‑1.6Li) would alter acute Schwann cell responses to injury. Using the RT4-D6P2T Schwannoma cell line (SCs), we tested extracts from freeze-killed cells (FKC) and nerves (FKN) as in vitro injury stimulants. Both FKC and FKN induced SC release of the macrophage chemoattractant protein 1 (MCP-1), a marker of the repair SC phenotype after injury. Next, FKC-stimulated cells exposed to Mg/Mg‑1.6Li reduced MCP-1 release by 30%, suggesting that these materials could have anti-inflammatory effects. Exposing FKC-treated cells to Mg/Mg‑1.6Li reduced the gene expression of the nerve growth factor (NGF), glial cell line-derived neurotrophic factor (GDNF), and myelin protein zero (MPZ), but not the p75 neurotrophin receptor. In the absence of FKC, Mg/Mg‑1.6Li treatment increased the expression of NGF, p75, and MPZ, which can be beneficial to nerve regeneration. Thus, the presence of Mg can differentially alter SCs, depending on the microenvironment. These results demonstrate the applicability of this in vitro nerve injury model, and that Mg has wide-ranging effects on the repair SC phenotype.

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Mechanism and application of 3D-printed degradable bioceramic scaffolds for bone repair

Abstract: 3D-printed biodegradable bioceramic materials have a broad research base and application prospects for bone repair applications.

Cited by 5 publications

References 222 publications

The Role of Bioceramics for Bone Regeneration: History, Mechanisms, and Future Perspectives

The Role of Bioceramics for Bone Regeneration: History, Mechanisms, and Future Perspectives

Advances in clinical applications of bioceramics in the new regenerative medicine era

Influence of Magnesium Degradation on Schwannoma Cell Responses to Nerve Injury Using an In Vitro Injury Model

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