Mechanically robust microfluidics and bulk wave acoustics to sort microparticles

Dauson, Erin R.; Gregory, Kelvin B.; Greve, David W.; Healy, Gregory P.; Oppenheim, Irving J.

doi:10.1117/12.2214394

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…Actuated by BAW, the acoustic streaming-induced drag force selectively delivered smaller particles to the target location, while the larger particles were dominated by acoustic radiation force. Dauson et al demonstrated a robust “tilt-angle” BAW-based microfluidic device for the separation of different-sized particles [ 45 ]. Tilt angled lead zirconate titanate (PZT) induced primary acoustic radiation force on particles, which deflected particles from the straight path based on the size of the particles.…”

Section: Baw-based Separationmentioning

confidence: 99%

Acoustic Microfluidic Separation Techniques and Bioapplications: A Review

Gao

Lin

et al. 2020

Micromachines

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Microfluidic separation technology has garnered significant attention over the past decade where particles are being separated at a micro/nanoscale in a rapid, low-cost, and simple manner. Amongst a myriad of separation technologies that have emerged thus far, acoustic microfluidic separation techniques are extremely apt to applications involving biological samples attributed to various advantages, including high controllability, biocompatibility, and non-invasive, label-free features. With that being said, downsides such as low throughput and dependence on external equipment still impede successful commercialization from laboratory-based prototypes. Here, we present a comprehensive review of recent advances in acoustic microfluidic separation techniques, along with exemplary applications. Specifically, an inclusive overview of fundamental theory and background is presented, then two sets of mechanisms underlying acoustic separation, bulk acoustic wave and surface acoustic wave, are introduced and discussed. Upon these summaries, we present a variety of applications based on acoustic separation. The primary focus is given to those associated with biological samples such as blood cells, cancer cells, proteins, bacteria, viruses, and DNA/RNA. Finally, we highlight the benefits and challenges behind burgeoning developments in the field and discuss the future perspectives and an outlook towards robust, integrated, and commercialized devices based on acoustic microfluidic separation.

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Section: Baw-based Separationmentioning

confidence: 99%

Acoustic Microfluidic Separation Techniques and Bioapplications: A Review

Gao

Lin

et al. 2020

Micromachines

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“…In another study instead of using PDMS microchannel, the channel is fabricated in a mechanically robust Plexiglas (polymethyl methacrylate, PMMA) prism. And the channel is then sandwiched in between two Lead Zirconium Titanate (PZT) elements to achieve bulk standing waves (Dauson et al, 2016). In this tilted angled PMMA and PZT based sorting device, the particle separation distance is increased and demonstrated by separation of 2 mm from 15 mm particles.…”

Section: Standing and Traveling Bulk Acoustic Wave's Particle Separationmentioning

confidence: 99%

Evaluation of acoustic-based particle separation methods

Ahmad

Bozkurt

Farhanieh

2019

WJE

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Purpose This paper aims to Separation and sorting of biological cells is desirable in many applications for analyzing cell properties, such as disease diagnostics, drugs delivery, chemical processing and therapeutics. Design/methodology/approach Acoustic energy-based bioparticle separation is a simple, viable, bio-compatible and contact-less technique using, which can separate the bioparticles based on their density and size, with-out labeling the sample particles. Findings Conventionally available bioparticle separation techniques as fluorescence and immunomagnetic may cause a serious threat to the life of the cells due to various compatibility issues. Moreover, they also require an extra pre-processing labeling step. Contrarily, label-free separation can be considered as an alternative solution to the traditional bio-particle separation methods, due to their simpler operating principles and lower cost constraints. Acoustic based particle separation methods have captured a lot of attention among the other reported label-free particle separation techniques because of the numerous advantages it offers. Practical implications This study tries to briefly cover the developments of different acoustic-based particle separation techniques over the years. Unlike the conventional surveys on general bioparticles separation, this study is focused particularly on the acoustic-based particle separation. The study would provide a comprehensive guide for the future researchers especially working in the field of the acoustics, in studying and designing the acoustic-based particle separation techniques. Originality/value The study insights a brief theory of different types of acoustic waves and their interaction with the bioparticles is considered, followed by acoustic-based particle separation devices reported till the date. The integration of acoustic-based separation techniques with other methods and with each other is also discussed. Finally, all major aspects like the approach, and productivity, etc., of the adopted acoustic particle separation methods are sketched in this article.

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Mechanically robust microfluidics and bulk wave acoustics to sort microparticles

Cited by 2 publications

References 3 publications

Acoustic Microfluidic Separation Techniques and Bioapplications: A Review

Acoustic Microfluidic Separation Techniques and Bioapplications: A Review

Evaluation of acoustic-based particle separation methods

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