Evaluation of acoustic-based particle separation methods

Abstract

Purpose This paper aims to Separation and sorting of biological cells is desirable in many applications for analyzing cell properties, such as disease diagnostics, drugs delivery, chemical processing and therapeutics. Design/methodology/approach Acoustic energy-based bioparticle separation is a simple, viable, bio-compatible and contact-less technique using, which can separate the bioparticles based on their density and size, with-out labeling the sample particles. Findings Conventionally available bioparticle separation techniques as fluorescence and immunomagnetic may cause a serious threat to the life of the cells due to various compatibility issues. Moreover, they also require an extra pre-processing labeling step. Contrarily, label-free separation can be considered as an alternative solution to the traditional bio-particle separation methods, due to their simpler operating principles and lower cost constraints. Acoustic based particle separation methods have captured a lot of attention among the other reported label-free particle separation techniques because of the numerous advantages it offers. Practical implications This study tries to briefly cover the developments of different acoustic-based particle separation techniques over the years. Unlike the conventional surveys on general bioparticles separation, this study is focused particularly on the acoustic-based particle separation. The study would provide a comprehensive guide for the future researchers especially working in the field of the acoustics, in studying and designing the acoustic-based particle separation techniques. Originality/value The study insights a brief theory of different types of acoustic waves and their interaction with the bioparticles is considered, followed by acoustic-based particle separation devices reported till the date. The integration of acoustic-based separation techniques with other methods and with each other is also discussed. Finally, all major aspects like the approach, and productivity, etc., of the adopted acoustic particle separation methods are sketched in this article.

On the acoustically induced fluid flow in particle separation systems employing standing surface acoustic waves – Part I

“…[1][2][3] Especially with regard to micro-and nanoparticle systems, numerous approaches could be achieved by using Lab-on-a-Chip devices in the field of microfluidics. [4][5][6][7] Besides passive methods, which use e.g. special channel geometries, [8][9][10] embedded microstructures 11 or filtration systems, 12,13 active methods received an increasing attention in research due to the higher flexibility and scalability by superimposing external fields.…”