Mechanically reinforced cell-laden scaffolds formed using alginate-based bioink printed onto the surface of a PCL/alginate mesh structure for regeneration of hard tissue

Kim, Yong Bok; Lee, Hyeongjin; Yang, Gi Hoon; Park, Chul Hyun; Lee, Dae‐Weon; Hwang, Hyun-Suk; Jung, Won‐Kyo; Yoon, Hun‐Young; Kim, GeunHyung

doi:10.1016/j.jcis.2015.09.044

Cited by 46 publications

(39 citation statements)

References 21 publications

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“…Wide range of printable biomaterials and inexpensive equipment are among extrusion bioprinting advantages. Many researchers have simply modified conventional commercial 3D printers to print biomaterials or developed their printing machines in-house to reduce the costs [2] , [24] , [29] , [31] , [33] , [34] , [35] , [38] , [41] , [42] , [43] , [49] , [55] , [56] . On the other hand, due to the need for development of bioprinters, commercial bioprinters have become widely available and employed by researchers [5] , [23] , [27] , [37] , [44] , [45] , [46] , [51] , [52] , [53] , [54] , focusing on enhancing the printing quality and suitability for printing wider range of biomaterials.…”

Section: Extrusion-based Bioprintingmentioning

confidence: 99%

See 1 more Smart Citation

3D bioprinting for biomedical devices and tissue engineering: A review of recent trends and advances

Derakhshanfar

Mbeleck

et al. 2018

Bioactive Materials

823

567

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3D printing, an additive manufacturing based technology for precise 3D construction, is currently widely employed to enhance applicability and function of cell laden scaffolds. Research on novel compatible biomaterials for bioprinting exhibiting fast crosslinking properties is an essential prerequisite toward advancing 3D printing applications in tissue engineering. Printability to improve fabrication process and cell encapsulation are two of the main factors to be considered in development of 3D bioprinting. Other important factors include but are not limited to printing fidelity, stability, crosslinking time, biocompatibility, cell encapsulation and proliferation, shear-thinning properties, and mechanical properties such as mechanical strength and elasticity. In this review, we recite recent promising advances in bioink development as well as bioprinting methods. Also, an effort has been made to include studies with diverse types of crosslinking methods such as photo, chemical and ultraviolet (UV). We also propose the challenges and future outlook of 3D bioprinting application in medical sciences and discuss the high performance bioinks.

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Section: Extrusion-based Bioprintingmentioning

confidence: 99%

“…Different methods have been used to accomplish this goal. In one study, for example, PCL/alginate struts were coated with alginate-based bioink to reinforce the structure [31] . The ratio of alginate crosslinking agent was also varied to find the optimum conditions for cell-coating.…”

Section: Properties and Parametersmentioning

confidence: 99%

3D bioprinting for biomedical devices and tissue engineering: A review of recent trends and advances

Derakhshanfar

Mbeleck

et al. 2018

Bioactive Materials

823

567

View full text Add to dashboard Cite

show abstract

“…In the studies, extrusion bioprinting was used to fabricate the PCL and cell loaded alginate construct. Printed constructs exhibited improved cartilage formation [84]. Cui et al [85] utilized inkjet printing technology to fabricate native cartilage structures by targeted printing of chondrocytes and PEG hydrogel to precise positions.…”

Section: Articular Cartilagementioning

confidence: 99%

Advances in three-dimensional bioprinting for hard tissue engineering

Park

Jung

Min

2016

Tissue Eng Regen Med

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The need for organ and tissue regeneration in patients continues to increase because of a scarcity of donors, as well as biocompatibility issues in transplant immune rejection. To address this, scientists have investigated artificial tissues as an alternative to transplantation. Threedimensional (3D) bioprinting technology is an additive manufacturing method that can be used for the fabrication of 3D functional tissues or organs. This technology promises to replicate the complex architecture of structures in natural tissue. To date, 3D bioprinting strategies have confirmed their potential practice in regenerative medicine to fabricate the transplantable hard tissues, including cartilage and bone. However, 3D bioprinting approaches still have unsolved challenges to realize 3D hard tissues. In this manuscript, the current technical development, challenges, and future prospects of 3D bioprinting for engineering hard tissues are reviewed.

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“…This precise positioning of multiple cell types in an organized manner can be achieved with 3D bioprinting [4]. Plenty of natural materials, such as gelatin [5,6], alginate [7][8][9], collagen [10,11], and synthetic materials like polycaprolactone (PCL) [12][13][14][15][16] and polyethylene glycol (PEG) [17][18][19][20][21][22], come in handy while printing a structure. Although the abovementioned natural materials are biocompatible, disadvantages such as mechanical instability, limited degradability, restricted cell proliferation, and differentiation challenged researchers to investigate more on natural materials [23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Tissue-Specific Bioink from Xenogeneic Sources for 3D Bioprinting of Tissue Constructs

Yeleswarapu¹,

Chameettachal²,

Bera³

et al. 2020

Xenotransplantation - Comprehensive Study

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3D bioprinting brings new aspirations to the tissue engineering and regenerative medicine research community. However, despite its huge potential, its growth towards translation is severely impeded due to lack of suitable materials, technological barrier, and appropriate validation models. Recently, the use of decellularized extracellular matrices (dECM) from animal sources is gaining attention as printable bioink as it can provide a microenvironment close to the native tissue. Hence, it is worth exploring the use of xenogeneic dECM and its translation potential for human application. However, extensive studies on immunogenicity, safety-related issues, and animal welfare-related ethics are yet to be streamlined. In addition, the regulatory concerns need to be addressed with utmost priority in order to expedite the use of xenogeneic dECM bioink for 3D bioprinted implantable tissues for human welfare.

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Mechanically reinforced cell-laden scaffolds formed using alginate-based bioink printed onto the surface of a PCL/alginate mesh structure for regeneration of hard tissue

Cited by 46 publications

References 21 publications

3D bioprinting for biomedical devices and tissue engineering: A review of recent trends and advances

3D bioprinting for biomedical devices and tissue engineering: A review of recent trends and advances

Advances in three-dimensional bioprinting for hard tissue engineering

Tissue-Specific Bioink from Xenogeneic Sources for 3D Bioprinting of Tissue Constructs

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