3D bioprinting for biomedical devices and tissue engineering: A review of recent trends and advances

Abstract

3D printing, an additive manufacturing based technology for precise 3D construction, is currently widely employed to enhance applicability and function of cell laden scaffolds. Research on novel compatible biomaterials for bioprinting exhibiting fast crosslinking properties is an essential prerequisite toward advancing 3D printing applications in tissue engineering. Printability to improve fabrication process and cell encapsulation are two of the main factors to be considered in development of 3D bioprinting. Other important factors include but are not limited to printing fidelity, stability, crosslinking time, biocompatibility, cell encapsulation and proliferation, shear-thinning properties, and mechanical properties such as mechanical strength and elasticity. In this review, we recite recent promising advances in bioink development as well as bioprinting methods. Also, an effort has been made to include studies with diverse types of crosslinking methods such as photo, chemical and ultraviolet (UV). We also propose the challenges and future outlook of 3D bioprinting application in medical sciences and discuss the high performance bioinks.

3D Primary Hepatocyte Culture Systems for Analyses of Liver Diseases, Drug Metabolism, and Toxicity: Emerging Culture Paradigms and Applications

“…Bioprinting approaches can be subdivided into three main methods: i) droplet‐based bioprinting, ii) extrusion‐based bioprinting, and iii) light‐assisted bioprinting. For technical details, we refer the interested reader to excellent recent reviews on this topic …”

Recent Advances in Enabling Technologies in 3D Printing for Precision Medicine

“…The next step in the process uses these inks to fabricate the constructs designed in the first step (Figure C). Many original 3D printing and biofabrication platforms ( Table 2 ) such as photolithography, inkjet printing, laser printing, robotic dispensing, and electrospinning are now available as standardized commercial systems and have been reviewed extensively elsewhere …”

Three‐dimensional bioprinting human cardiac tissue chips of using a painting needle method

“…In recent years, various methods for arranging and stacking cells in 3D using printing devices have been developed (Calvert, ) and the created 3D tissues are being actively developed for drug discovery research and regenerative medicine. The main technologies and devices used for cell printing (Araki et al, ; Derakhshanfar et al, ; Gungor‐Ozkerim, Inci, Zhang, Khademhosseini & Dokmeci, ; Jang, Yi, & Cho, ; Matsusaki, Sakaue, Kadowaki, & Akashi, ; Murphy & Atala, ) are inkjet printers (thermal or piezoelectric type), microextrusion printers (dispenser type), and laser‐assisted printers (pulse laser type). The types of materials that can be ejected from these devices are limited, however, and there are problems with the printing speed, positional accuracy, printed cell viability, and density.…”