Mechanical Test of Human Cerebral Aneurysm Specimens Obtained From Surgical Clipping

Abstract

The walls of the blood vessels involved with cerebral aneurysms present different mechanical properties, when compared with those of normal artery. Consequently the models which may describe then predict an aneurysm rupture need as input their mechanical properties. This paper describes the experimental determination of the mechanical properties of the tissues of the blood vessels affected with a cerebral aneurysm. In particular, we determine and discuss the critical elongation and the rupture strength. The affected tissues were obtained from surgical clipping and extraction; six specimens were tested. The mechanical tests were performed in a tensile device. The experimental data was fitted numerically with a Mooney–Rivlin hyper elastic model. The model was compared with previous published data.

Rupture limit evaluation of human cerebral aneurysms wall: Experimental study

“…In terms of comparisons, we are able to compare parameter 1 with those obtained in the literature. In (Valencia et al 2015), they extracted from a Mooney-Rivlin hyperelastic model, an average value of parameters 01 + 10 , equivalent to our 1 , of about 0.17 MPa, while in (Toth et al 2007) they found 0.12 MPa. They are of same order than our average value for 1 : 0.11 MPa.…”

“…Only 7 aneurysms were tested for an average strain rupture limit of 37%. More recently, works of (Cebral et al, 2015) and (Valencia et al, 2015), extracted also rupture limit values from their uniaxial traction tests. In both articles few samples were tested, due to the difficulty of getting aneurysms from surgery.…”

Different stages of the evolution of cerebral aneurysms: joint analysis of mechanical test data and histological analysis of aneurysm tissue

“…The data of various mechanical experiments show significantly different results depending on the method of transportation of the samples, the sensitivity of the used tensile machine and the method of the experiment [3][4][5][6][7]. It was shown [8] that the difference in the mechanical properties of aneurysms among representatives and between samples with different experimental techniques can be comparable. In this regard, the use of coupled tests for the classification of aneurysm tissues becomes important.…”

Relationship between cerebral aneurysm wall stiffness and rupture risk

“…In terms of comparisons, we are able to compare parameter C 1 with those obtained in the literature. Valencia et al (2015) extracted from a Mooney-Rivlin hyperelastic model, an average value of parameters C 01 + C 10 , equivalent to our C 1 , of about 0.17 MPa, while…”