Different stages of the evolution of cerebral aneurysms: joint analysis of mechanical test data and histological analysis of aneurysm tissue

Abstract

In practical neurosurgery, an important issue is determining the status of the aneurysm and predicting its further growth, rupture or stabilization. The main approaches for the study of risk analysis asessment are computational hydrodynamics and analysis of the mechanics of the wall of cerebral aneurysm. In this paper, an analysis of various sections of the wall of cerebral aneurysm is given, combining mechanical test data and histological examination data. It was shown that, along with significant differences in mechanics, a different degree of calcification is observed in the tissue, which indicates a different level of impaired transport of substances inside the tissue.

A pilot study on biaxial mechanical, collagen microstructural, and morphological characterizations of a resected human intracranial aneurysm tissue

“…The peak strain of our aneurysm tissue in the X -direction (0.25) falls within this range whereas the Y -direction (0.89) does not, which further supports the idea that the X -direction of our tissue is approximately aligned near the meridional axis. On the other hand, Parshin et al 19 showed notably larger values for the peak failure strain of one posterior inferior cerebellar aneurysm sample compared to the average in Robertson et al (2.86 vs 0.36), and the peak deformations in both directions of our aneurysm sample fall within this range. The large difference in the peak failure strains from these studies may suggest that Parshin et al tested an aneurysm sample approximately oriented in the circumferential direction (i.e., orthogonal to the meridional direction).…”

A Pilot Study on Biaxial Mechanical, Collagen Microstructural, and Morphological Characterizations of a Resected Human Intracranial Aneurysm Tissue

“…The peak strain of our aneurysm tissue in the X-direction (0.25) falls within this range whereas the Y-direction (0.89) does not, which further supports the idea that the X-direction of our tissue is approximately aligned near the meridional axis. On the other hand, Parshin et al 19 showed notably larger values for the peak failure strain of one posterior inferior cerebellar aneurysm sample compared to the average in Robertson et al…”