Mechanical properties of the bone‐porous biomaterial interface: Elastic behavior

Abstract

SummaryThe possibility of evaluating the elastic moduli of the bone-porous biomaterial interface by treating it as a two-phase composite is discussed. Methods of placing bounds on the elastic moduli of such a composite are presented and applied to five materials currently being considered for use in porous prosthetic devices: 316 stainless steel, titanium, cobalt-chromium-molybdenum alloy (Vitallium), alumina (Al*O3), and high density polyethylene. The results show that when the prosthetic material becomes completely ingrown with bone, the elastic modulus of the composite becomes more compatible with bone. Titanium appears to be very favorable. Young's modulus for bulk titanium is about four times that of bone, while the fully ingrown composite has a Young's modulus approximately twice that of bone. Similar results obtain for the other elastic moduli. It is noted that the results for 316 SS apply to all surgical stainless steels, those for Co-Cr-Mo apply to other Co-Cr alloys and those for titanium apply to alloyed titanium.

Influence of hydroxyapatite granule size, porosity, and crystallinity on tissue reactionin vivo. Part A: synthesis, characterization of the materials, andSEManalysis

“…; Mistry & Mikos ; Moyle et al. ). The characteristic bands of the synthesized materials are: After 1 h of sintering, two bands were detected at 3432.2 and 1642.6/cm as a result of the vibration of the adsorbed water in apatites.…”

“…Fig. 3 displays the FTIR spectra of the milled samples after thermal treatment in the range 600-1000°C for 1 h. In general, the characteristic groups of apatites are PO 4 3À , OH À , and HPO 4 2À groups which commonly appears in 4000-400/cm region in the FTIR spectra (Klenke et al 2008;Mistry & Mikos 2005;Moyle et al 1973). The characteristic bands of the synthesized materials are: After 1 h of sintering, two bands were detected at 3432.2 and 1642.6/cm as a result of the vibration of the adsorbed water in apatites.…”

“…It has been established that pore sizes of at least 40 μm are required for minimal bone in growth, whereas pore sizes of 100–350 μm are considered optimal (Moyle et al. ). In a study analyzing the effect of pore size and porosity on bone healing in a critical size rat cranial defect, it was shown that smaller pore sizes (100 μm) induce greater amounts of bone healing than larger pore sizes (500 μm) (Petrie Aronin et al.…”

“…Finally, pore size and porosity affect in vivo and in vitro cell signaling which in turn affects osteoblastic differentiation of MSCs and the production of extracellular matrix (ECM) proteins . It has been established that pore sizes of at least 40 lm are required for minimal bone in growth, whereas pore sizes of 100-350 lm are considered optimal (Moyle et al 1973). In a study analyzing the effect of pore size and porosity on bone healing in a critical size rat cranial defect, it was shown that smaller pore sizes (100 lm) induce greater amounts of bone healing than larger pore sizes (500 lm) (Petrie Aronin et al 2009).…”

Effective anisotropic elastic constants of bimaterial interphases: comparison between experimental and analytical techniques

“…Composite analyses have also been used to simplify the study of bone-implant interphase mechanics [14,15]. Moyle et al [1][2][3][4][5][6][7][8][9][10][11][12][13][14] evaluated the upper and lower bounds on the elastic constants of biomaterial interfaces for different synthetic materials, using both Hill-Paul and Hashin-Shtrikman theories.…”