Mechanical properties of natural chitosan/hydroxyapatite/magnetite nanocomposites for tissue engineering applications

Abstract

Chitosan (CS), hydroxyapatite (HA), and magnetite (Fe3O4) have been broadly employed for bone treatment applications. Having a hybrid biomaterial composed of the aforementioned constituents not only accumulates the useful characteristics of each component, but also provides outstanding composite properties. In the present research, mechanical properties of pure CS, CS/HA, CS/HA/magnetite, and CS/magnetite were evaluated by the measurements of bending strength, elastic modulus, compressive strength and hardness values. Moreover, the morphology of the bending fracture surfaces were characterized using a scanning electron microscope (SEM) and an image analyzer. Studies were also conducted to examine the biological response of the human Mesenchymal Stem Cells (hMSCs) on different composites. We conclude that, although all of these composites possess in-vitro biocompatibility, adding hydroxyapatite and magnetite to the chitosan matrix can noticeably enhance the mechanical properties of the pure chitosan.

Evaluation of mechanical and biocompatibility properties of hydroxyapatite/manganese dioxide nanocomposite scaffolds for bone tissue engineering application

“…01‐074‐0566) 28 . The obtained patterns are in agreement with Kim et al 29 and Heidari et al 30,31 MnO 2 peaks were also seen at angles of 18.20, 28.88, 35.46, 37.5, 41.97, 49.39, and 60.3° 26,32 . Given that the intensity of the peaks of the pattern of Figure 2B is greater than that of Figure 2A, it is concluded that the HA crystallinity increased by adding MnO 2 .…”

“…Changing this ratio changes the chemical properties of this substance 6 . HA is used for bone tissue engineering due to its excellent biocompatibility and bone mineralization, bioactivity, non‐toxicity and non‐inflammation and immunology in bone tissue engineering 7‐9 . Although the elasticity modulus of HA is higher than the bone, it alone does not have the mechanical properties of the bone.…”

A tri-component knee plug for the 3rd generation of autologous chondrocyte implantation

“…The majority of the inorganic component of natural bone is calcium phosphates, which makes this group of materials very populate in bone tissue engineering [61][62][63] . Among all calcium phosphates, HA (Ca 10 (PO4) 6 (OH) 2 ) and TCP (Ca 3 (PO 4 ) 2 ) have been effective elements of many bone substitutes and scaffolds as they are able to effectively facilitate osteogenesis [64][65][66][67] . TCP is known as a bioceramic with higher degradability compared to other calcium phosphates [68][69][70][71] .…”

Cartilage and facial muscle tissue engineering and regeneration: a mini review

“…The most important part of a scaffold being used for any tissue engineering and regeneration is the design [54][55][56][57][58][59][60][61]. One of the most guaranteed ways to ensure that the design of the scaffold will fit the needs and anatomical design of the affected area is to use clinical imaging data that will define the shape of the anatomical structure in combination with a global and local image database that consists of many different templates for the scaffold design [62,63].…”