Mechanical properties of cemented tailings backfill with chloride-free antifreeze

Zhou, Yibo; Yang, Bo; Liu, Shuaigang; Tian, Xichun; Yang, Haigang

doi:10.1007/s11356-022-24924-3

Cited by 3 publications

(1 citation statement)

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“…[ 116,117 ] PNPs can also act as vectors for pollutants of organic origin, and their association is largely dependent on their mode of protein binding, especially, in differential pH and electrolyte systems. [ 29,118,119 ] Hence, critically evaluating the toxic effects of PNPs in organism's health relies on their interactive modulation of proteins. The proceeding sub‐sections will detail the diversified outcomes and mechanistic specifics pertaining to protein structure/folding stability, and aggregation.…”

Section: Molecular Insights Into Protein‐pnp Interactionsmentioning

confidence: 99%

Mechanistic Insights into Cellular and Molecular Basis of Protein‐Nanoplastic Interactions

Naidu,

Nagar,

Poluri

2023

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Plastic waste is ubiquitously present across the world, and its nano/sub‐micron analogues (plastic nanoparticles, PNPs), raise severe environmental concerns affecting organisms’ health. Considering the direct and indirect toxic implications of PNPs, their biological impacts are actively being studied; lately, with special emphasis on cellular and molecular mechanistic intricacies. Combinatorial OMICS studies identified proteins as major regulators of PNP mediated cellular toxicity via activation of oxidative enzymes and generation of ROS. Alteration of protein function by PNPs results in DNA damage, organellar dysfunction, and autophagy, thus resulting in inflammation/cell death. The molecular mechanistic basis of these cellular toxic endeavors is fine‐tuned at the level of structural alterations in proteins of physiological relevance. Detailed biophysical studies on such protein‐PNP interactions evidenced prominent modifications in their structural architecture and conformational energy landscape. Another essential aspect of the protein‐PNP interactions includes bioenzymatic plastic degradation perspective, as the interactive units of plastics are essentially nano‐sized. Combining all these attributes of protein‐PNP interactions, the current review comprehensively documented the contemporary understanding of the concerned interactions in the light of cellular, molecular, kinetic/thermodynamic details. Additionally, the applicatory, economical facet of these interactions, PNP biogeochemical cycle and enzymatic advances pertaining to plastic degradation has also been discussed.

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Section: Molecular Insights Into Protein‐pnp Interactionsmentioning

confidence: 99%