Mechanical properties of biocompatible clay/P(MEO 2 MA- co -OEGMA) nanocomposite hydrogels

Xiang, Hengxue; Meng, Xiaorong; Cunningham, Alexander J.; Chen, Wei; Sun, Bin

doi:10.1016/j.jmbbm.2017.04.026

Cited by 30 publications

(15 citation statements)

References 39 publications

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“…Nevertheless, hydrogels have insufficient mechanical properties . Many strategies have been put forward to improve the mechanical properties of hydrogels, including nanocomposite hydrogels, , double-network (DN) hydrogels, , interpenetrating networks (IPN) hydrogels, , fiber-reinforced hydrogels, and microsphere-incorporated hydrogels . Of these, the interpenetrating network (IPN) is a useful strategy to fabricate a tough hydrogel by the formation of a new polymer network in the presence of the other network.…”

Section: Introductionmentioning

confidence: 99%

Polyelectrolyte and Antipolyelectrolyte Effects for Dual Salt-Responsive Interpenetrating Network Hydrogels

2019

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This work presents a salt-responsive interpenetrating network (IPN) hydrogel with effective antimicrobial properties and surface regeneration. The hydrogels were engineered using the double network strategy to form loosely cross-linked zwitterionic poly(sulfobetaine vinylimidazole) (pSBVI) networks into the highly cross-linked cationic poly((trimethylamino)ethyl methacrylate chloride) (pTMAEMA) framework via photopolymerization. The pTMAEMA/pSBVI hydrogel has strong mechanical properties, with a fracture stress 120× higher than single network pTMAEMA hydrogel. In addition, there is inverse correlation between elastic modulus and elastic strain of pTMAEMA/pSBVI hydrogels as a function of ionic strength. The cationic pTMAEMA and zwitterionic pSBVI show opposite swelling behaviors in salt solutions due to the polyelectrolyte effect and antipolyelectrolyte effect. Therefore, the pTMAEMA/pSBVI hydrogel elicits a significant interfacial transition in solutions with different ionic strengths. The IPN hydrogels have switchable lubrication and optical transmittance between deionized water and 1.0 M NaCl solution. The protein adsorption tests further confirmed the switchable interface of salt-responsive IPN hydrogels. In addition, bacterial attachment test on pTMAEMA/pSBVI hydrogels with Staphylococcus epidermidis (S. epidermidis) and Escherichia coli (E. coli) show bacterial killing rates of the IPN hydrogel over 80% for S. epidermidis and 90% for E. coli after incubating the hydrogels in the bacterial solutions for 24 h. The bacterial release rate from the IPN hydrogel reached 96% after washing with 1.0 M NaCl solution. Furthermore, the excellent reusability of the pTMAEMA/pSBVI hydrogels was demonstrated by the high bacterial killing and bacterial release rates after five kill/release cycles. The work presents a new stimuli-responsive IPN hydrogel with structural modulation, tunable antimicrobial properties, and surface regeneration by ionic strength. Integrating two salt-responsive polymers with mutually independent actions into a single material provides a new direction for smart materials with potential medical and industrial applications.

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Section: Introductionmentioning

confidence: 99%

Polyelectrolyte and Antipolyelectrolyte Effects for Dual Salt-Responsive Interpenetrating Network Hydrogels

2019

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“…Most of such clay–polymer nanocomposite hydrogels with excellent mechanical performance have been prepared by the in situ polymerization method [4,5,6,7,8]. Their studies have shown that the tensile stress increased with the increase of clay concentration [9,10] and interactions between clay and polymer are attributed to noncovalent bonds, e.g., hydrogen bonds between the amide groups and silanol groups (Si–OH) and/or siloxane units (Si-O-Si) play an important role on the cross-link of clay-poly(alkyl acrylamide) nanocomposite hydrogel [11]. In addition, the effect of clay type (synthetic hectorite, fluorinated hectorite, natural montmorillonite, or sepiolite magnesium silicate) on the mechanical performance of the nanocomposite hydrogels has been examined, so that it has been shown that synthetic hectorite (laponite XLG)—the polymer nanocomposite hydrogel has the best mechanical performance [11].…”

Section: Introductionmentioning

confidence: 99%

Mechanical Properties and Structures of Clay-Polyelectrolyte Blend Hydrogels

Takeno

Nagai

2018

Gels

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Our recent studies have shown that the hydrogels prepared by blending clay, a dispersant of clay, and a polyelectrolyte (sodium polyacrylate (PAAS)) possess excellent mechanical properties. In order to clarify the mechanism of the toughness, we have so far investigated the effects of the composition, molecular mass of the polymer, and kinds of polymers on the mechanical properties. This study has focused upon the mechanical properties and structures of the clay/PAAS gels using three kinds of smectite clay minerals such as synthetic hectorite (laponite XLG), saponite (sumecton-SA), montmorillonite (kunipia-F), whose particle size becomes larger according to the sequence. Laponite/PAAS and sumecton/PAAS gels were quite tough for high compression, whereas kunipia-F/PAAS did not gelate. In comparison between sumecton/PAAS gel and laponite/PAAS gel, the mechanical property of the former gel was poorer than that of the latter gel due to the inhomogeneous distribution of clay platelets in the gel. Synchrotron small-angle X-ray scattering experiments revealed that their clay platelets laid down in the stretching direction under elongation. Furthermore, it was found that sumecton/PAAS gel under elongation was arranged with an interparticle distance of ~6.3 nm in the direction perpendicular to the stretching. Such local ordering under elongation may originate in local aggregation of sumecton platelets in the original state without elongation.

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“…The compressive modulus of clay30 was 2.99 ± 0.06 MPa, indicating that the compression modulus was 3.65 times higher than that of clay0 hydrogels. This can be attributed to the production of complex chemically crosslinked networks and the secondary interactions between the polymer and nanoclay [ 30 , 31 ].…”

Section: Resultsmentioning

confidence: 99%

Biomimetic Mineralization of Tannic Acid-Supplemented HEMA/SBMA Nanocomposite Hydrogels

Chen

Ou²,

Chien

2021

Polymers

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This study developed a tannic acid (TA)-supplemented 2-hydroxyethyl methacrylate-co-sulfobetaine methacrylate (HEMA-co-SBMA) nanocomposite hydrogel with mineralization and antibacterial functions. Initially, hybrid hydrogels were synthesized by incorporating SBMA into the HEMA network and the influence of SBMA on the chemical structure, water content, mechanical properties, and antibacterial characteristics of the hybrid HEMA/SBMA hydrogels was examined. Then, nanoclay (Laponite XLG) was introduced into the hybrid HEMA/SBMA hydrogels and the effects evaluated of the nanoclay on the chemical structure, water content, and mechanical properties of these supplemented hydrogels. The 50/50 hybrid HEMA/SBMA hydrogel with 30 mg/mL nanoclay showed outstanding mechanical properties (3 MPa) and water content (60%) compared to pure polyHEMA hydrogels. TA then went on to be incorporated into these hybrid nanocomposite hydrogels and its effects investigated on biomimetic mineralization. Scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX) showed that bone-like spheroidal precipitates with a Ca/P ratio of 1.67% were observed after 28 days within these mineralized hydrogels. These mineralized hydrogels demonstrated an almost 1.5-fold increase in compressive moduli compared to the hydrogels without mineralization. These multifunctional hydrogels display good mechanical and biomimetic properties and may have applications in bone regeneration therapies.

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Mechanical properties of biocompatible clay/P(MEO 2 MA- co -OEGMA) nanocomposite hydrogels

Cited by 30 publications

References 39 publications

Polyelectrolyte and Antipolyelectrolyte Effects for Dual Salt-Responsive Interpenetrating Network Hydrogels

Polyelectrolyte and Antipolyelectrolyte Effects for Dual Salt-Responsive Interpenetrating Network Hydrogels

Mechanical Properties and Structures of Clay-Polyelectrolyte Blend Hydrogels

Biomimetic Mineralization of Tannic Acid-Supplemented HEMA/SBMA Nanocomposite Hydrogels

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