Mechanical properties of alginate hydrogels manufactured using external gelation

Kaklamani, Georgia; Cheneler, David; Grover, Liam M.; Adams, M.J.; Bowen, James

doi:10.1016/j.jmbbm.2014.04.013

Cited by 164 publications

(107 citation statements)

References 41 publications

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“…The mechanical properties of the alginate for bone bioprinting are poor (for instance, the stiffness during elastic deformations of the bone ranges between 15–25 GPa [40], whereas alginate’s is so much lower: 150–550 kPa [41]). We can hereby conclude that the combination of alginate and other polymers such as hydroxyapatite, polycaprolactone, or biosilica, among others, improves the mimicking of the mechanical properties of bone in printed 3D constructs.…”

Section: The Use Of Alginate In Three-dimensional (3d) Bioprintingmentioning

confidence: 99%

Applications of Alginate-Based Bioinks in 3D Bioprinting

Axpe

Oyen

2016

IJMS

519

343

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Three-dimensional (3D) bioprinting is on the cusp of permitting the direct fabrication of artificial living tissue. Multicellular building blocks (bioinks) are dispensed layer by layer and scaled for the target construct. However, only a few materials are able to fulfill the considerable requirements for suitable bioink formulation, a critical component of efficient 3D bioprinting. Alginate, a naturally occurring polysaccharide, is clearly the most commonly employed material in current bioinks. Here, we discuss the benefits and disadvantages of the use of alginate in 3D bioprinting by summarizing the most recent studies that used alginate for printing vascular tissue, bone and cartilage. In addition, other breakthroughs in the use of alginate in bioprinting are discussed, including strategies to improve its structural and degradation characteristics. In this review, we organize the available literature in order to inspire and accelerate novel alginate-based bioink formulations with enhanced properties for future applications in basic research, drug screening and regenerative medicine.

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Section: The Use Of Alginate In Three-dimensional (3d) Bioprintingmentioning

confidence: 99%

Applications of Alginate-Based Bioinks in 3D Bioprinting

Axpe

Oyen

2016

IJMS

519

343

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“…Mechanical properties of TE scaffolds are attracting increasing interest [283–285,290,295,296]. Artificial tissues must provide appropriate flexibility and elasticity and adequate mechanical strength [297], suitable for reconstructing or replacing lost or damaged tissues and organs [298].…”

Section: Overview Of Gel-based Materials By Applicationmentioning

confidence: 99%

“…Artificial tissues must provide appropriate flexibility and elasticity and adequate mechanical strength [297], suitable for reconstructing or replacing lost or damaged tissues and organs [298]. Moreover, cells are able to sense mechanical properties of their environment, which affect their proliferation, differentiation, geometry and adhesion [285,295,299–301]. Hydrogels with sufficiently high modulus and mechanical strength are generally hard to prepare [289,302].…”

Section: Overview Of Gel-based Materials By Applicationmentioning

confidence: 99%

Role of mechanical factors in applications of stimuli-responsive polymer gels – Status and prospects

Goponenko

Dzenis

2016

Polymer

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Due to their unique characteristics such as multifold change of volume in response to minute change in the environment, resemblance of soft biological tissues, ability to operate in wet environments, and chemical tailorability, stimuli responsive gels represent a versatile and very promising class of materials for sensors, muscle-type actuators, biomedical applications, and autonomous intelligent structures. Success of these materials in practical applications largely depends on their ability to fulfill application-specific mechanical requirements. This article provides an overview of recent application-driven development of covalent polymer gels with special emphasis on the relevant mechanical factors and properties. A short account of mechanisms of gel swelling and mechanical characteristics of importance to stimuli-responsive gels is presented. The review highlights major barriers for wider application of these materials and discusses latest advances and potential future directions toward overcoming these barriers, including interpenetrating networks, homogeneous networks, nanocomposites, and nanofilamentary gels.

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“…In order to achieve a homogeneous gel, the internal gelation method has been established as it can control introduce or release of the crosslinking ion from insoluble calcium salt in an acidified medium (Goh, Heng, & Chan, 2012a;Kaklamani, Cheneler, Grover, Adams, & Bowen, 2014;Lee & Mooney, 2012;Song, Yu, Gao, Liu, & Ma, 2013). However, internal gelation has the disadvantage of difficulty to be applied on a large scale (Goh, Heng, & Chan, 2012a;Kaklamani et al, 2014;Sun & Tan, 2013). Conversely, external gelation is the most relevant method of alginate crosslinking, from both the industrial and the biotechnological point of view, as it can be simply obtained by dropping alginate-based matrices in a crosslinking solution.…”

Section: Introductionmentioning

confidence: 99%