Mechanical properties and drug release of microcapsules containing quaternized‐chitosan‐modified reduced graphene oxide in the capsular wall

Abstract

Reduced graphene oxide (rGO) sheets were first modified with 2-hydroxypropyltrimethyl ammonium chloride chitosan (HACC), and these modified rGO sheets (named HACC-rGO) were used as reinforcement materials and introduced to the walls of chitosan (CS) microcapsules. All of the monodisperse microcapsules were conveniently generated by a gas-liquid microfluidic technique. The results of scanning electron microscopy, X-ray diffraction, and thermogravimetric analysis all demonstrate that the HACC-rGO sheets existed and were dispersed in the capsular shell. The HACC-rGO-reinforced CS microcapsules showed better mechanical strength and better chemical stability with an a-cyclodextrin solution than the CS microcapsules without HACC-rGO. Importantly, the HACC-rGO-reinforced CS microcapsules exhibited a slower drug-release behavior and provide a method for the control of the release rate of drug-loaded microcapsules. In an in vitro cytotoxicity evaluation by a 3-(4,5-dimethyl-2-thiazolyl)-2,5diphenyl-2-H-tetrazolium bromide assay, the Schwann cells still showed good cell viability after they were treated by extracts of the CS/HACC-rGO microcapsules with concentrations ranging from 0.02 to 2000 lg/mL. Therefore, the HACC-rGO-reinforced CS microcapsules are promising for applications in the fields of drug delivery and controlled release. V C 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44549.

Electrical, optical and mechanical properties of chitosan biocomposites

“…14 Thus, CS biocomposites can be used in areas such as food packaging, 2,6 adsorption, 15,16 energy conversion, 9,17 sensor, 18–20 tissue engineering 21–24 and drug delivery. 25,26…”

“…14 Thus, CS biocomposites can be used in areas such as food packaging, 2,6 adsorption, 15,16 energy conversion, 9,17 sensor, [18][19][20] tissue engineering [21][22][23][24] and drug delivery. 25,26 The main objective of this study is to prepare conductive, mechanically developed, UV-protecting CS/GNP and CS/MWCNT biocomposite films in a simple and completely eco-friendly method. Within this scope, the GNP and MWCNT doped, biocompatible CS biocomposites were prepared using a spin coating method for optical and electrical measurements and by a drop casting method for mechanical measurements.…”

Facile synthesis of novel fluorescent phenol formaldehyde resin nanospheres for drug release

“…[8][9][10] Almost all anti-tumor drugs can damage normal cells while killing cancer cells, especially for added value, among which vigorous bone marrow hematopoietic cells are more seriously damaged. [11][12][13] To solve these drawbacks while exploring successful deliveries of anti-cancer drugs for drug deliveries as well as controlled drug release specifically for tumorous regions, various types of nanocarrier systems have been attracting wide attention over the last decade, which include organic materials, such as, liposomes, 14,15 micelles, 16,17 viruses, 18,19 and microcapsules, 20,21 as well as inorganic nanoparticles, such as, carbon nanotubes, 22 mesoporous silica nanospheres (MSNs) 23,24 and gold nanoparticles (Au NPs). 25,26 Recently, porous nanomaterials (microporous zeolites and mesoporous silica) in biomedical applications attract people's great attention.…”

Recent Developments Concerning the Dispersion Methods and Mechanisms of Graphene

“…In recent years, many scholars have done experiments and tests on this method. Chen et al [88] used 2-hydroxypropyltrimethyl ammonium chloride chitosan (HACC)-modified GO via charges interaction between them and reduced GO by hydrazine hydrate to obtain HACC-RGO. They also explored the dispersion and electrochemical properties of HACC-RGO in different pH solutions.…”