Mechanical Micronization of Lipoaspirates for Regenerative Therapy

Zhu, Huidong; Ge, Jinbo; Chen, Xihang; Lu, Feng; Cai, Junrong

doi:10.3791/58765

Cited by 10 publications

(7 citation statements)

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“…Collagen type I is a macromolecular fragment, fibrillary assemblies of which can form matrix assemblies with other types of collagen to increase tissue support. 16 The cartoon diagram would show the difference in preparation of SVF-gel versus nanofat (Fig. 8).…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Study of SVF-gel Compared With Nanofat Combined With High-density Fat in the Treatment of Early Periorbital Aging

Yang

et al. 2022

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: To compare the effectiveness of transplantation with stromal vascular fraction (SVF)-gel or nanofat combined with high-density fat prepared with the Coleman technique (nanofat+high-density fat) to restore volume in the periorbital region or for periorbital rejuvenation in early periorbital aging.Methods: This retrospective study included 103 patients who received a transplant of SVF-gel (n = 58) or nanofat+highdensity fat (n = 45) to restore volume in the periorbital region (n = 85) or for periorbital rejuvenation (n = 18) in our hospital between January 2016 and January 2020. Patient satisfaction and the reoperation rate were evaluated.Results: All patients had improved periorbital contouring and augmentation. Among the patients that received treatment to restore volume in the periorbital region, 17% and 65.9% of patients administered SVF-gel were very satisfied or satisfied, and 5.3% and 44.7% of patients administered nanofat+highdensity fat were very satisfied or satisfied.Patients administered SVF-gel were significantly more satisfied than patients administered nanofat+high-density fat with improvements in periorbital contouring (p < 0.05). Among the patients that received treatment for periorbital rejuvenation, 54.5% and 27.3% of patients administered SVF-gel were very satisfied or satisfied, and 28.6% and 42.8% of patients administered nanofat+high-density fat were very satisfied or satisfied. There was no significant difference between groups (p > 0.05). Some patients underwent a second operation after 3 to 8 months. Patients administered SVF-gel to restore volume in the periorbital region had a significantly lower reoperation rate than patients administered nanofat+high-density fat (12.7% [6/47] vs. 34.2% [13/38]; p < 0.05). There was no significant difference in the reoperation rate in patients treated for periorbital rejuvenation (9.1% [1/11] vs. 14.3% [1/7]; p > 0.05).Conclusion: SVF-gel and nanofat+high-density fat are effective for restoring volume in the periorbital region and for periorbital rejuvenation in early periorbital aging. The reoperation rate was significantly lower and patient satisfaction scores were significantly higher in patients administered SVFgel to restore volume in the periorbital region compared with patients administered nanofat+high-density fat.

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Section: Discussionmentioning

confidence: 99%

A Retrospective Study of SVF-gel Compared With Nanofat Combined With High-density Fat in the Treatment of Early Periorbital Aging

Yang

et al. 2022

Ophthalmic Plastic &Amp; Reconstructive Surgery

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“…Adipose-derived stem cells have a great multidifferentiation potential; therefore, grafts enriched with these cells have been developed to improve the retention rate and therapeutic efficacy. 27 Cell-assisted lipotransfer and stromal vascular fraction gel, which are generated by enriching Coleman fat with adipose-derived stem cells, 28 have significantly improved long-term retention rates 16,29 and are good alternatives for treating scleroderma.…”

Section: Discussionmentioning

confidence: 99%

Adipose-Derived Stem Cell–Enriched Lipotransfer Reverses Skin Sclerosis by Suppressing Dermal Inflammation

Jiang

Wang

Lin

et al. 2022

Plastic &Amp; Reconstructive Surgery

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cleroderma is a chronic autoimmune disease that results in skin and organ fibrosis and microvascular abnormalities, with an incidence of 2.7 per 100,000 people. 1,2 More than 90 percent of patients develop sclerotic skin changes such as dermatogenic contractures, sclerodactyly, perioral plication, microstomia, and mask-like facial stiffness. Lesions can develop further, leading to hair loss, diminished sweating, hyperpigmentation, depigmentation, or severe pruritus, all

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“…7,11 SVF-gel, contains concentrated SVF and ECM and very little oil, is an alternative for the regeneration purpose. 12,13 The aging process affect each layer of the facial tissue differently. For each individual patient, it is very common that problems originated from more than one layer of tissue are presented and needed to be solved.…”

Section: Discussionmentioning

confidence: 99%

“…11 The most recent reports described the development of SVF-gel, containing concentrated ECM and SVF and almost no oil; this gel showed remarkable capacity for regeneration with modest volumization capability. 12,13 However, to make the best of the variety of these fat products, and deal with the complexity of clinical problems, it is vital that we understand how to select appropriate fat produces for a combined application. In this article, we report our knowledge and experience of a pyramidal multiple-theory (multi-type, multi-method, and multilayer) for facial fat grafting.…”

Section: Introductionmentioning

confidence: 99%

Pyramidal multiple‐theory (multi‐type, multi‐method and multi‐layer) for facial fat grafting

Shi

Qian

et al. 2022

J of Cosmetic Dermatology

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Background Age‐related changes to the face pertinent anatomy and important aspects of autologous fat grafting have been widely applied in facial rejuvenation. Various types of autologous fat products (Macrofat, Microfat, SEFF, nanofat, and SVF‐gel) with different properties and applicabilities have been introduced and available for surgeons. Methods Key differences between common techniques for fat processing and infiltration. Develop a plan for patients based on site‐specific facial anatomical zones, we suggested a pyramidal multiple‐theory (multi‐type, multi‐method and multi‐layer) for facial fat grafting. Based on the complicated mechanism of the face decrepitude in different layers of facial soft tissue, autologous fat products with various particle sizes and components into different layers. Results Fifty‐eight patients underwent this facial fat grafting strategy from June 2020 to Jan 2022. All achieved cosmetic improvements, with higher patients' satisfaction, and minor complications. Our facial fat grafting strategy takes advantage of different fat products and is able to address the physiological tissue changes during aging, more properly and targetedly, than the traditional facial fat grafting. Conclusions Fat grafting to the face aids in volume restoration and rejuvenation, thereby addressing soft‐tissue atrophy associated with the aging face, acquired conditions, or congenital malformations. The technique described as “lipo‐tumescence” has been successfully used in the breast and other regions of the body that have radiation damage and is discussed in this article specifically for the face and neck.

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Mechanical Micronization of Lipoaspirates for Regenerative Therapy

Cited by 10 publications

References 0 publications

A Retrospective Study of SVF-gel Compared With Nanofat Combined With High-density Fat in the Treatment of Early Periorbital Aging

A Retrospective Study of SVF-gel Compared With Nanofat Combined With High-density Fat in the Treatment of Early Periorbital Aging

Adipose-Derived Stem Cell–Enriched Lipotransfer Reverses Skin Sclerosis by Suppressing Dermal Inflammation

Pyramidal multiple‐theory (multi‐type, multi‐method and multi‐layer) for facial fat grafting

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