Mechanical Measurements in Assessing Aging

Vogel, H. Gerhard

doi:10.1007/978-3-642-78157-5_10

Cited by 7 publications

(2 citation statements)

References 52 publications

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“…Collagen, the principal component of the human dermis, has a high tensile strength, and this strength is critically important in preventing the skin from deforming or tearing when confronted with increased mechanical stress. Skin thickness, primarily a measure of the integrity of the dermis, has been shown to diminish with age after the seventh decade of life, 10–12 and it has been suggested that this loss of dermal volume reflects a linear decline in dermal collagen content throughout life 13 . This collagen loss, confirmed with biochemical 14 and immunohistochemical 15 collagen assays, is even greater in photodamaged skin than in simply intrinsically aged skin 15 .…”

Section: Discussionmentioning

confidence: 99%

Predictable Tissue Shrinkage During Frozen Section Histopathologic Processing for Mohs Micrographic Surgery

2001

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Section: Discussionmentioning

confidence: 99%

Predictable Tissue Shrinkage During Frozen Section Histopathologic Processing for Mohs Micrographic Surgery

2001

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“…Collagen, the principal component of the human dermis, has a high tensile strength, and this strength is critically important in preventing the skin from deforming or tearing when confronted with increased mechanical stress. Skin thickness, primarily a measure of the integrity of the dermis, has been shown to diminish with age after the seventh decade of life, [10][11][12] and it has been suggested that this loss of dermal volume reflects a linear decline in dermal collagen content throughout life. 13 This collagen loss, confirmed with biochemical 14 and immunohistochemical 15 collagen assays, is even greater in photodamaged skin than in simply intrinsically aged skin.…”

Section: Discussionmentioning

confidence: 99%

Predictable Tissue Shrinkage During Frozen Section Histopathologic Processing for Mohs Micrographic Surgery

Gardner¹,

Sumner²,

Cook³

2001

Dermatologic Surgery

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background. When confronted with a histologic specimen that is appreciably smaller than the same tissue specimen immediately after acquisition, the Mohs surgeon is faced with two possibilities, namely that the tissue has either shrunken during laboratory processing or that the histologic specimen is incomplete due to the introduction of technical errors during embedding, cutting, or staining of the skin specimen. Because the entire objective of Mohs micrographic surgery is to precisely examine the entire surgical margin of skin specimens, the surgeon must be able to determine that any size discrepancies introduced during laboratory processing are not related to incomplete surgical specimens. Although there are anecdotal suggestions that skin, like other human tissues, undergoes some degree of shrinkage during routine frozen section processing, the exact nature and magnitude of this phenomenon has not been previously investigated. objective. To quantify the degree of tissue shrinkage in Mohs micrographic surgical specimens processed with routine frozen sections and subsequent hematoxylin and eosin staining. methods. A total of 117 Mohs surgery patients (135 cutaneous tumors) were prospectively enrolled. The dimensions of initial stage surgical specimens were determined after removal

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Pharmacological models in dermatology

Vogel

Schölkens

et al. 2002

Drug Discovery and Evaluation

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Mechanical Measurements in Assessing Aging

Cited by 7 publications

References 52 publications

Predictable Tissue Shrinkage During Frozen Section Histopathologic Processing for Mohs Micrographic Surgery

Predictable Tissue Shrinkage During Frozen Section Histopathologic Processing for Mohs Micrographic Surgery

Predictable Tissue Shrinkage During Frozen Section Histopathologic Processing for Mohs Micrographic Surgery

Pharmacological models in dermatology

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