Mechanical insertion properties of calcium‐phosphate implant coatings

Hägi, Tobias T.; Enggist, Lukas; Michel, D; Ferguson, Stephen J.; Liu, Yuelian; Hunziker, Ernst B.

doi:10.1111/j.1600-0501.2010.01916.x

Cited by 33 publications

(23 citation statements)

References 28 publications

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“…Bovine serum albumin (BSA) was used as a model protein, in place of more expensive proteins such as BMP-2, to study the coating properties as well as the kinetics of the protein release. Different concentrations of BSA were added into the solution used for forming the coating [ 11 , 15 , 24 , 31 ]. BMP-2 and parathyroid hormone (PTH) have been biomimetically incorporated into CaP coatings to improve osseointegration of implants in vivo and the characteristics of the coatings were also evaluated [ 14 , 16 , 32 - 38 ].…”

Section: Biomimetic Calcium Phosphate Coatingsmentioning

confidence: 99%

A Review Paper on Biomimetic Calcium Phosphate Coatings

Lin¹,

Groot²,

Wang³

et al. 2015

TOBEJ

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Biomimetic calcium phosphate coatings have been developed for bone regeneration and repair because of their biocompatibility, osteoconductivity, and easy preparation. They can be rendered osteoinductive by incorporating an osteogenic agent, such as bone morphogenetic protein 2 (BMP-2), into the crystalline lattice work in physiological situations. The biomimetic calcium phosphate coating enables a controlled, slow and local release of BMP-2 when it undergoes cell mediated coating degradation induced by multinuclear cells, such as osteoclasts and foreign body giant cells, which mimics a physiologically similar release mode, to achieve sustained ectopic or orthotopic bone formation. Therefore, biomimetic calcium phosphate coatings are considered to be a promising delivery vehicle for osteogenic agents. In this review, we present an overview of biomimetic calcium phosphate coatings including their preparation techniques, physico-chemical properties, potential as drug carrier, and their pre-clinical application both in ectopic and orthotopic animal models. We briefly review some features of hydroxyapatite coatings and their clinical applications to gain insight into the clinical applications of biomimetic calcium phosphate coatings in the near future.

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Section: Biomimetic Calcium Phosphate Coatingsmentioning

confidence: 99%

A Review Paper on Biomimetic Calcium Phosphate Coatings

Lin¹,

Groot²,

Wang³

et al. 2015

TOBEJ

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show abstract

“…These established specimens of polyurethane origin have been widely used for implant testing evaluating different surgical techniques and implant surface modifications with regard to primary implant stability (Hägi et al. ; Tabassum et al. ).…”

mentioning

confidence: 99%

A novel standardized bone model for thermal evaluation of bone osteotomies with various irrigation methods

Strbac

Giannis

Unger

et al. 2013

Clinical Oral Implants Res

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“…The biomimetic coating obtained in this study was mainly composed of carbonated CaP, an essential inorganic part of hard tissues with osteo-conductive function [30][31][32] . Many studies have demonstrated that apatite coating can facilitate osteogenic differentiation, reduce fibrous encapsulation, and promote bone ingrowth [33][34][35] . In addition, as the BMP-2 loading process was conducted in a natural, neutral and physiological environment, the biological activities of BMP-2, i.e.…”

Section: Discussionmentioning

confidence: 99%

<i>In vitro</i> study on the osteogenesis enhancement effect of BMP-2 incorporated biomimetic apatite coating on titanium surfaces

Zhu

Zhang

et al. 2017

Dent. Mater. J.

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To fabricate a sustained-release delivery system of bone morphogenetic protein (BMP-2) on titanium surface, explore the effect of BMP-2 concentration on the loading/release behavior of BMP-2 and evaluate the cell compatibility of the system in vitro, pure titanium specimens were immersed into supersaturated calcium phosphate solutions (SCP) containing 4 different concentrations of BMP-2: 0, 50, 100, 200 and 400 ng/mL. Biomimetic calcium phosphate coating was formed on titanium surface and BMP-2 was incorporated into the coating through co-deposition. The release profile of BMP-2 suggested that BMP-2 were delivered sustainably up to 20 days. CCK-8 and ALP assay showed that 200 group and 400 ng/mL BMP-2 group have significant effect on promoting MC3T3-E1 cell proliferation and differentiation. The BMP-2 incorporated into the hybrid coating released in a sustained manner and significantly promoted the proliferation and differentiation of MC3T3-E1 on the titanium surface.

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Mechanical insertion properties of calcium‐phosphate implant coatings

Cited by 33 publications

References 28 publications

A Review Paper on Biomimetic Calcium Phosphate Coatings

A Review Paper on Biomimetic Calcium Phosphate Coatings

A novel standardized bone model for thermal evaluation of bone osteotomies with various irrigation methods

<i>In vitro</i> study on the osteogenesis enhancement effect of BMP-2 incorporated biomimetic apatite coating on titanium surfaces

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