Mechanical evaluation of bone gap filled with rigid formulations castor oil polyurethane and chitosan in horses

Moreira, Rodrigo Crispim; Graaf, Guilherme Maia Mulder van de; Pereira, César Augusto Martins; Zoppa, André Luis do Valle de

doi:10.1590/0103-8478cr20150838

Cited by 3 publications

(4 citation statements)

References 5 publications

(3 reference statements)

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“…However, polymer implants must be biocompatible and bioabsorbable [ 4 , 8 ]. There are few studies on the use of polymer implants in horses, with most of them involving their use to repair bone fractures [ 13 , 14 , 15 , 16 , 17 ]. Therefore, polymeric materials represent potential alternatives to the use of autologous and heterologous grafts, which have been limited to fracture correction in equine medicine [ 13 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…There are few studies on the use of polymer implants in horses, with most of them involving their use to repair bone fractures [ 13 , 14 , 15 , 16 , 17 ]. Therefore, polymeric materials represent potential alternatives to the use of autologous and heterologous grafts, which have been limited to fracture correction in equine medicine [ 13 , 15 ]. Furthermore, biomaterials have been used for the treatment of joint damage [ 18 , 19 , 20 ] and drug delivery [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Long-Term Evaluation of Poly(lactic acid) (PLA) Implants in a Horse: An Experimental Pilot Study

et al. 2021

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In horses, there is an increasing interest in developing long-lasting drug formulations, with biopolymers as viable carrier alternatives in addition to their use as scaffolds, suture threads, screws, pins, and plates for orthopedic surgeries. This communication focuses on the prolonged biocompatibility and biodegradation of PLA, prepared by hot pressing at 180 °C. Six samples were implanted subcutaneously on the lateral surface of the neck of one horse. The polymers remained implanted for 24 to 57 weeks. Physical examination, plasma fibrinogen, and the mechanical nociceptive threshold (MNT) were performed. After 24, 28, 34, 38, and 57 weeks, the materials were removed for histochemical analysis using hematoxylin-eosin and scanning electron microscopy (SEM). There were no essential clinical changes. MNT decreased after the implantation procedure, returning to normal after 48 h. A foreign body response was observed by histopathologic evaluation up to 38 weeks. At 57 weeks, no polymer or fibrotic capsules were identified. SEM showed surface roughness suggesting a biodegradation process, with an increase in the median pore diameter. As in the histopathological evaluation, it was not possible to detect the polymer 57 weeks after implantation. PLA showed biocompatible degradation and these findings may contribute to future research in the biomedical area.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Long-Term Evaluation of Poly(lactic acid) (PLA) Implants in a Horse: An Experimental Pilot Study

et al. 2021

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show abstract

“…However, polymer implants must be biocompatible and bioabsorbable [1,5]. There are few studies on the use of polymer implants in horses, with most of them involving their use to repair bone fractures [10][11][12][13][14]. Therefore, polymeric materials represent potential alternatives to the use of autologous and heterologous grafts, which have been limited to fracture correction in equine medicine [10,12].…”

Section: Introductionmentioning

confidence: 99%

“…There are few studies on the use of polymer implants in horses, with most of them involving their use to repair bone fractures [10][11][12][13][14]. Therefore, polymeric materials represent potential alternatives to the use of autologous and heterologous grafts, which have been limited to fracture correction in equine medicine [10,12]. Furthermore, biomaterials have been used for the treatment of joint damage [15][16][17] and drug delivery [18].…”

Section: Introductionmentioning

confidence: 99%

Long-Term Evaluation of the Poly(Lactic Acid) (PLA) Implants in a Horse: An Experimental Pilot Study

Carvalho¹,

Conde²,

Antonioli³

et al. 2021

Preprint

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In horses, there is an increasing interest in developing long-lasting drug formulations, with bi-opolymers as viable carrier alternatives in addition to their use as scaffolds, suture threads, screws, pins, and plates for orthopedic surgeries. This communication focuses on the prolonged biocompatibility and biodegradation of PLA, prepared by hot pressing at 180 ºC. Six samples were implanted subcutaneously on the lateral surface of the neck of one horse. The polymers remained implanted for 24 to 57 weeks. Physical examination, plasma fibrinogen, and the mechanical noci-ceptive threshold (MNT) were performed. After 24, 28, 34, 38, and 57 weeks, the materials were removed for histochemical analysis using hematoxylin-eosin and scanning electron microscopy (SEM). There were no essential clinical changes. MNT decreased after the implantation procedure, returning to normal after 48h. A foreign body response was observed by histopathologic evalua-tion up to 38 weeks. At 57 weeks, no polymer or fibrotic capsules were identified. SEM showed surface roughness suggesting a biodegradation process, with an increase in the average pore di-ameter. As in the histopathological evaluation, it was not possible to detect the polymer 57 weeks after implantation. PLA showed biocompatible degradation and these findings may contribute to future research in the biomedical area.

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Biocompatibility and biodegradation of poly(lactic acid) (PLA) and an immiscible PLA/poly(ε-caprolactone) (PCL) blend compatibilized by poly(ε-caprolactone-b-tetrahydrofuran) implanted in horses

Carvalho

Conde

Antonioli

et al. 2020

Polym J

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Mechanical evaluation of bone gap filled with rigid formulations castor oil polyurethane and chitosan in horses

Abstract: Often fractures of long bones in horses are comminuted and form bone gaps, which represent a major challenge for the fixation of these fractures by loss of contact between the fragments. Bone grafts help in treating this kind of fracture and synthetic

Cited by 3 publications

References 5 publications

Long-Term Evaluation of Poly(lactic acid) (PLA) Implants in a Horse: An Experimental Pilot Study

Long-Term Evaluation of Poly(lactic acid) (PLA) Implants in a Horse: An Experimental Pilot Study

Long-Term Evaluation of the Poly(Lactic Acid) (PLA) Implants in a Horse: An Experimental Pilot Study

Biocompatibility and biodegradation of poly(lactic acid) (PLA) and an immiscible PLA/poly(ε-caprolactone) (PCL) blend compatibilized by poly(ε-caprolactone-b-tetrahydrofuran) implanted in horses

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