Mechanical design of DNA nanostructures

Castro, Carlos E.; Su, Hai‐Jun; Marras, Alexander E.; Zhou, Lifeng; Johnson, Joshua A.

doi:10.1039/c4nr07153k

Cited by 122 publications

(108 citation statements)

References 96 publications

(172 reference statements)

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“…272,273,274 It is also possible to vary the number and strength of DNA-mediated interactions between nanoparticles 275,276 which can lead to interesting stimulus-dependent responses, 277 allowing the creation of new, environmentally-responsive nanostructures. 278,279,280,281,282 …”

Section: Dna-based Self-assemblymentioning

confidence: 99%

Nanomanufacturing: A Perspective

2016

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Nanomanufacturing, the commercially-scalable and economically-sustainable mass production of nanoscale materials and devices, represents the tangible outcome of the nanotechnology revolution. In contrast to those used in nanofabrication for research purposes, nanomanufacturing processes must satisfy the additional constraints of cost, throughput, and time to market. Taking silicon integrated circuit manufacturing as a baseline, we consider the factors involved in matching processes with products, examining the characteristics and potential of top-down and bottom-up processes, and their combination. We also discuss how a careful assessment of the way in which function can be made to follow form can enable high-volume manufacturing of nanoscale structures with the desired useful, and exciting, properties.

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Section: Dna-based Self-assemblymentioning

confidence: 99%

Nanomanufacturing: A Perspective

2016

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“…Analogous to macroscopic machines, the group introduced discrete single-stranded DNA joints in their structures allowing for specified rotational and/or translational movement of more rigid dsDNA components. Doing so, the researchers succeeded in constructing several interesting molecular motors resembling common macroscopic tools such as a crank-slider, hinge, and scissor-lift [43].…”

Section: Dynamic Dna Devicesmentioning

confidence: 99%

Interfacing DNA nanodevices with biology: challenges, solutions and perspectives

Vinther

Kjems

2016

New J. Phys.

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The cellular machinery performs millions of complex reactions with extreme precision at nanoscale. From studying these reactions, scientists have become inspired to build artificial nanosized molecular devices with programmed functions. One of the fundamental tools in designing and creating these nanodevices is molecular self-assembly. In nature, deoxyribonucleic acid (DNA) is inarguably one of the most remarkable self-assembling molecules. Governed by the Watson-Crick base-pairing rules, DNA assembles with a structural reliability and predictability based on sequence composition unlike any other complex biological polymer. This consistency has enabled rational design of hundreds of two-and three-dimensional shapes with a molecular precision and homogeneity not preceded by any other known technology at the nanometer scale.During the last two decades, DNA nanotechnology has undergone a rapid evolution pioneered by the work of Nadrian Seeman (Kallenbach et al 1983 Nature 205 829-31). Especially the introduction of the versatile DNA Origami technique by Rothemund (2006 Nature 440 297-302) led to an efflorescence of new DNA-based self-assembled nanostructures (Andersen et al 2009 Nature 459 73-6, Douglas et al 2009 Nature 459 414-8, Dietz et al 2009 Science 325 725-30, Han et al 2011 Science 332 342-6, Iinuma et al 2014 Science 344 65-9), and variations of this technique have contributed to an increasing repertoire of DNA nanostructures (Wei et al 2012 Nature 485 623-6, Ke et al 2012 Science 338 1177-83, Benson et al 2015 Nature 523 441-4, Zhang et al 2015 Nat. Nanotechnol. 10 779-84, Scheible et al 2015 Small 11 5200-5). These advances have naturally triggered the question:What can these DNA nanostructures be used for?One of the leading proposals of use for DNA nanotechnology has been in biology and biomedicine acting as a molecular 'nanorobot' or smart drug interacting with the cellular machinery. In this review, we will explore and examine the perspective of DNA nanotechnology for such use. We summarize which requirements DNA nanostructures must fulfil to function in cellular environments and inside living organisms. In addition, we highlight recent advances in interfacing DNA nanostructures with biology.For a molecular device to act in vivo it should preferably (i) constitute a well-defined structural entity, (ii) be biocompatible, (iii) target the relevant bodily compartment or cells, and (iv) execute a desired function (figure 1). The motivation for each requirement will be addressed in further detail in the following sections.

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“…Here, two rod‐like DNA origami structures with different geometries and stiffnesses are synthesized as basic elements . A third, more complex structure is assembled by connecting the two basic structures in a novel way.…”

Section: Introductionmentioning

confidence: 99%

Concept, synthesis, and structural characterization of DNA origami based self-thermophoretic nanoswimmers

Herms

Günther

Sperling

et al. 2017

Phys. Status Solidi A

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We present a novel concept for the synthesis of a selfthermophoretic nanoswimmer, a construct consisting of a gold nanoparticle as a heating element and an artificial DNA structure as a thermophoretic active part. For the latter, DNA origami technique was applied to design and synthesize rodlike bundle structures as well as a more complex 2-leg construct. This novel concept is based on the versatile and easy-to-apply DNA origami toolbox to realize Janus particlelike structures with various geometries. We synthesized a variety of different nanoswimmers and characterized them in terms of structure, yield, and thermal stability.Schematic representation of the construction principle of a self-thermophoretic nanoswimmer consisting of a DNA origami structure and a gold nanoparticle. Inset: TEM image of such a nanoswimmer structure.

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Mechanical design of DNA nanostructures

Cited by 122 publications

References 96 publications

Nanomanufacturing: A Perspective

Nanomanufacturing: A Perspective

Interfacing DNA nanodevices with biology: challenges, solutions and perspectives

Concept, synthesis, and structural characterization of DNA origami based self-thermophoretic nanoswimmers

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