Mechanical Considerations of Bioprinted Tissue

Abstract

Bioprinting enables the fabrication of engineered tissues with complex features and is conducive to automated tissue manufacturing and scale up. As cell systems and tissues are dynamic and very responsive to environmental cues, including biomechanical stimuli, the form and function of bioprinted tissues can change dramatically after printing. Here, we discuss tissue biomechanics relevant to printed cell systems and tissues emphasizing the dynamic and complex relationship between cell behavior, matrix deposition, and tissue forces. Furthermore, we provide perspectives on the control and manipulation of mechanical forces and designed boundary conditions for tissue constructs in printing-based approaches and strategies.

Morphological Effects of the Microenvironment Structure on Human Fetal Lung Fibroblast Cells

“…Thus, collagen-based hydrogels are frequently used in the tissue engineering field as bioinks [87]. Although the composition and concentration of different biomolecules and synthetic components in the bioink can affect cellular behaviour and the printability of the constructs, the design of such constructs is another factor which must be considered [88,89]. Careful planning of the bioprinted design is crucial, and its effect on cells' exposure to nutrients, proliferation, and migration must be understood and considered.…”