Mechanical characterisation of the human dura mater, falx cerebri and superior sagittal sinus

Walsh, Darragh R.; Ross, Aisling M.; Newport, David; Zhou, Zhou; Kearns, Jamie; Fearon, Conor; Lorigan, Jennifer; Mulvihill, John J.

doi:10.1016/j.actbio.2021.07.043

Cited by 24 publications

(13 citation statements)

References 84 publications

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“…The dura from these studies comes from various regions of the skull and it is possible that the differing regions may be optimised for varying degrees of absolute strength rather than flexibility. Recently, Young's modulus of the sagittal sinus in the mediolateral direction has been directly measured in humans and was found to be 5.2 MPa at a strain of approximately 1% 18 which is similar to our findings. In the controls the deflected arc length was 0.6% longer than the resting chord length giving an average strain similar to 18 .…”

Section: Discussionsupporting

confidence: 91%

Modelling of the dilated sagittal sinuses found in multiple sclerosis suggests increased wall stiffness may be a contributing factor

Bateman

Lechner‐Scott

Bateman³

2022

Sci Rep

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The cross-sectional area of the superior sagittal sinus (SSS) is larger in multiple sclerosis than normal and correlates with disease severity and progression. The sinus could be enlarged due to a decrease in the pressure difference between the lumen and the subarachnoid space, an increase in wall thickness or increased wall stiffness. The cross-sectional area of the SSS and straight sinus (ST) were measured in 103 patients with multiple sclerosis and compared to 50 controls. The cross-sectional area of the SSS and ST were increased by 20% and 13% compared to the controls (p = 0.005 and 0.02 respectively). The deflection of the wall of the sinus was estimated. The change in pressure gradient, wall thickness or elastic modulus between groups was calculated by modelling the walls as simply supported beams. To account for these findings, the modelling suggests either a 70% reduction in transmural venous pressure or a 2.4 fold increase in SSS wall stiffness plus an 11% increase in wall thickness or a combination of changes. An increase in sinus pressure, although the most straight forward possibility to account for the change in sinus size may exist in only a minority of patients. An increase in sinus wall stiffness and thickness may need further investigation.

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Section: Discussionsupporting

confidence: 91%

Modelling of the dilated sagittal sinuses found in multiple sclerosis suggests increased wall stiffness may be a contributing factor

Bateman

Lechner‐Scott

Bateman³

2022

Sci Rep

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“…Normally, the main blood supply to the dura comes from the external carotid artery (ECA) system, and venous blood is collected through the sinus and enters the venous system. The fenestrated vasculature is a characteristic of the dural vascular architecture ( 8 , 11 , 22 ). Recent findings challenged the traditional concept: dural sinus is more than just a drainage channel but may serve as a neuroimmune interface ( 23 ).…”

Section: Meningeal Immune Systemmentioning

confidence: 99%

“…The outermost layer adjacent to the skull is the dura mater, which could be distinguished into the periosteal layer and the meningeal layer ( 8 ). The dura mater could perform efficient immune surveillance by driving immune cell circulation and maintaining infiltration homeostasis ( 22 , 23 ). The dural sinus is the characteristic structure of the dural vascular architecture.…”

Section: Meningeal Immune Systemmentioning

confidence: 99%

New insight into DAVF pathology—Clues from meningeal immunity

Peng

Song

et al. 2022

Front. Immunol.

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In recent years, with the current access in techniques, studies have significantly advanced the knowledge on meningeal immunity, revealing that the central nervous system (CNS) border acts as an immune landscape. The latest concept of meningeal immune system is a tertiary structure, which is a comprehensive overview of the meningeal immune system from macro to micro. We comprehensively reviewed recent advances in meningeal immunity, particularly the new understanding of the dural sinus and meningeal lymphatics. Moreover, based on the clues from the meningeal immunity, new insights were proposed into the dural arteriovenous fistula (DAVF) pathology, aiming to provide novel ideas for DAVF understanding.

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“…The meninges layers have been confirmed to act as significant aspect in nervous system physiology, traumatic brain injury, and forensic pathology. Generally, the mechanical properties of the brain have been effectively studied, and the cranial meninges layers have nearly or almost been neglected [ 23 ]. Thus, the interest of exploring the optical clearing (OC) effect on the DM’s collagen could be a suitable method to investigate human head injuries, helping the evaluation of subdural bleeding related to meninges, specifically subdural hematoma [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Confocal Raman Micro-Spectroscopy for Discrimination of Glycerol Diffusivity in Ex Vivo Porcine Dura Mater

Jaafar

Darvin

Tuchin

et al. 2022

Life

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Dura mater (DM) is a connective tissue with dense collagen, which is a protective membrane surrounding the human brain. The optical clearing (OC) method was used to make DM more transparent, thereby allowing to increase in-depth investigation by confocal Raman micro-spectroscopy and estimate the diffusivity of 50% glycerol and water migration. Glycerol concentration was obtained, and the diffusion coefficient was calculated, which ranged from 9.6 × 10−6 to 3.0 × 10−5 cm2/s. Collagen-related Raman band intensities were significantly increased for all depths from 50 to 200 µm after treatment. In addition, the changes in water content during OC showed that 50% glycerol induces tissue dehydration. Weakly and strongly bound water types were found to be most concentrated, playing a major role in the glycerol-induced water flux and OC. Results show that OC is an efficient method for controlling the DM optical properties, thereby enhancing the in-depth probing for laser therapy and diagnostics of the brain. DM is a comparable to various collagen-containing tissues and organs, such as sclera of eyes and skin dermis.

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Mechanical characterisation of the human dura mater, falx cerebri and superior sagittal sinus

Cited by 24 publications

References 84 publications

Modelling of the dilated sagittal sinuses found in multiple sclerosis suggests increased wall stiffness may be a contributing factor

Modelling of the dilated sagittal sinuses found in multiple sclerosis suggests increased wall stiffness may be a contributing factor

New insight into DAVF pathology—Clues from meningeal immunity

Confocal Raman Micro-Spectroscopy for Discrimination of Glycerol Diffusivity in Ex Vivo Porcine Dura Mater

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