Mechanical and permeability properties of porous scaffolds developed by a Voronoi tessellation for bone tissue engineering

Zhao, Ze; Li, Junchao; Yao, Dingrou; Wei, Yuan

doi:10.1039/d2tb01478e

Cited by 9 publications

(6 citation statements)

References 52 publications

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“…Secondly, Equation 5 is tested in the design for a 3D Voronoi structure of a patient's trabecular bone, which may be used to examine the structural fragility resulting from osteoporosis 44 . As Voronoi structures have been shown to accurately model the bone microenvironment 16,24 , a Voronoi structure is designed to model a patient's trabecular bone derived from E calculated in a segment of the patient's bone microenvironment (1388 edges) 44 . However, a more detailed model would require further parameters, such as anisotropy and inhomogeneity, to increase accuracy.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…The emergence of additive manufacturing has extended the application of Voronoi tessellation from mere analysis to the generation of 3D scaffolds, i.e., Voronoi structures with mesh wrapped around the wireframes. Voronoi scaffolds have been 3D printed as supports for hollow objects 19 , interlocking architecture 20 , optimal lightweight structures [21][22][23] , patient specific bone scaffolds 24,25 , for surgical practice 26 , for patient education of upcoming procedures 27 , regenerative medicine and wound healing techniques 28 , implantable drug delivery 29 and T-cell culturing environments 14 .…”

Section: Introductionmentioning

confidence: 99%

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Two conjectures on 3D Voronoi structures: a toolkit with biomedical case studies

Todd,

Chin,

Coppens

2024

Mol. Syst. Des. Eng.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Two conjectures on 3D Voronoi structures: a toolkit with biomedical case studies

Todd,

Chin,

Coppens

2024

Mol. Syst. Des. Eng.

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“…Polyamides are currently used for a wide range of biomedical applications [ 114 ] including bone regeneration scaffolds [ 115 ], tissue engineering [ 116 ] and membranes for protein separation [ 117 ]. In this section, the use of polyamide for the production of catheters, surgical sutures and dental implants is reviewed.…”

Section: Nylon As Materials For Biomedical Devicesmentioning

confidence: 99%

Nylons with Applications in Energy Generators, 3D Printing and Biomedicine

Arioli,

Puiggalí,

Franco

2024

Molecules

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Linear polyamides, known as nylons, are a class of synthetic polymers with a wide range of applications due to their outstanding properties, such as chemical and thermal resistance or mechanical strength. These polymers have been used in various fields: from common and domestic applications, such as socks and fishing nets, to industrial gears or water purification membranes. By their durability, flexibility and wear resistance, nylons are now being used in addictive manufacturing technology as a good material choice to produce sophisticated devices with precise and complex geometric shapes. Furthermore, the emergence of triboelectric nanogenerators and the development of biomaterials have highlighted the versatility and utility of these materials. Due to their ability to enhance triboelectric performance and the range of applications, nylons show a potential use as tribo-positive materials. Because of the easy control of their shape, they can be subsequently integrated into nanogenerators. The use of nylons has also extended into the field of biomaterials, where their biocompatibility, mechanical strength and versatility have paved the way for groundbreaking advances in medical devices as dental implants, catheters and non-absorbable surgical sutures. By means of 3D bioprinting, nylons have been used to develop scaffolds, joint implants and drug carriers with tailored properties for various biomedical applications. The present paper aims to collect evidence of these recently specific applications of nylons by reviewing the literature produced in recent decades, with a special focus on the newer technologies in the field of energy harvesting and biomedicine.

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“…There are various computer-aided methods to design porous materials regarding the configuration of their internal topology. They can roughly be classified as constructed with (i) spatially arranged cells composed of struts, (ii) triply periodic minimal surfaces (TPMS), and (iii) irregular bio-inspired stochastic or Voronoi tessellation structures [5,[76][77][78][79][80]. The latter two techniques provide versatile capabilities to engineer porous scaffolds with controllable mechanical performance and enhanced cell colonization and proliferation [78,81].…”

Section: Computational Techniques For Am-aimed Cell Design and Virtua...mentioning

confidence: 99%

“…They can roughly be classified as constructed with (i) spatially arranged cells composed of struts, (ii) triply periodic minimal surfaces (TPMS), and (iii) irregular bio-inspired stochastic or Voronoi tessellation structures [5,[76][77][78][79][80]. The latter two techniques provide versatile capabilities to engineer porous scaffolds with controllable mechanical performance and enhanced cell colonization and proliferation [78,81]. While irregular structures mimic the natural composition of bone tissues, their design, and AM processing are laborious because of higher scattering of results among the generated structures as well as poorer basis for comparison of their performances.…”

Section: Computational Techniques For Am-aimed Cell Design and Virtua...mentioning

confidence: 99%

Development of Bioactive Scaffolds for Orthopedic Applications by Designing Additively Manufactured Titanium Porous Structures: A Critical Review

Kiselevskiy,

Anisimova,

Kapustin

et al. 2023

Biomimetics

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We overview recent findings achieved in the field of model-driven development of additively manufactured porous materials for the development of a new generation of bioactive implants for orthopedic applications. Porous structures produced from biocompatible titanium alloys using selective laser melting can present a promising material to design scaffolds with regulated mechanical properties and with the capacity to be loaded with pharmaceutical products. Adjusting pore geometry, one could control elastic modulus and strength/fatigue properties of the engineered structures to be compatible with bone tissues, thus preventing the stress shield effect when replacing a diseased bone fragment. Adsorption of medicals by internal spaces would make it possible to emit the antibiotic and anti-tumor agents into surrounding tissues. The developed internal porosity and surface roughness can provide the desired vascularization and osteointegration. We critically analyze the recent advances in the field featuring model design approaches, virtual testing of the designed structures, capabilities of additive printing of porous structures, biomedical issues of the engineered scaffolds, and so on. Special attention is paid to highlighting the actual problems in the field and the ways of their solutions.

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Mechanical and permeability properties of porous scaffolds developed by a Voronoi tessellation for bone tissue engineering

Abstract: Irregular porous structures for guided bone regeneration applications have gained increasing attention as they are similar to human bone and more suitable for bone tissue growth. However, pore irregularity as...

Cited by 9 publications

References 52 publications

Two conjectures on 3D Voronoi structures: a toolkit with biomedical case studies

Two conjectures on 3D Voronoi structures: a toolkit with biomedical case studies

Nylons with Applications in Energy Generators, 3D Printing and Biomedicine

Development of Bioactive Scaffolds for Orthopedic Applications by Designing Additively Manufactured Titanium Porous Structures: A Critical Review

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