Mechanical and microstructural properties of polycaprolactone scaffolds with one-dimensional, two-dimensional, and three-dimensional orthogonally oriented porous architectures produced by selective laser sintering

Eshraghi, Shaun; Das, Suman

doi:10.1016/j.actbio.2010.02.002

Cited by 434 publications

(293 citation statements)

References 78 publications

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“…whether the part oriented is parallel or perpendicular to the laser path 13 . However, this variation is presumably due to variations in local densities in the directions parallel or perpendicular to the laser path and density is directly related to grey-value.…”

Section: Meanmentioning

confidence: 99%

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Predicting the Elastic Properties of Selective Laser Sintered PCL/β-TCP Bone Scaffold Materials Using Computational Modelling

2013

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Publication InformationDoyle, H., Lohfeld, S., McHugh, P.E. (2013) 'Predicting the elastic properties of selective laser sintered PCL/b-TCP bone scaffold materials using computational modelling'. Annals Of Biomedical Engineering, 42 (3):661-677. Publisher SpringerLink to publisher's version http://link.springer.com/article/10.1007%2Fs10439-013-0913-4Item record http://hdl.handle.net/10379/5524 DOI http://dx.doi.org/10.1007/s10439-013-0913-4Accepted manuscript, published in Annals of Biomedical Engineering 09/2013; 42(3), pp 661-677. The final publication is available at Springer via http://dx.doi.org/10.1007/s10439-013-0913-4Title: Predicting the elastic properties of selective laser sintered PCL/β-TCP bone scaffold materials using computational modelling. AbstractThis study assesses the ability of finite element models to capture the mechanical behaviour of sintered orthopaedic scaffold materials. Individual scaffold struts were fabricated from a 50:50 wt% poly-ε-caprolactone (PCL) /β-tricalcium phosphate (β-TCP) blend, using selective laser sintering (SLS). The tensile elastic modulus of single struts was determined experimentally. High resolution finite element models of single struts were generated from micro-CT scans (28.8µm resolution) and an effective strut elastic modulus was calculated from tensile loading simulations. Three material assignment methods were employed: (1) homogeneous PCL elastic constants, (2) composite PCL/ β-TCP elastic constants based on rule of mixtures, and (3) heterogeneous distribution of micromechanically-determined elastic constants. In comparison with experimental results, the use of homogeneous PCL properties gave a good estimate of strut modulus; however it is not sufficiently representative of the real material as it neglects the β-TCP phase. The rule of mixtures method significantly overestimated strut modulus, while there was no significant difference between strut modulus evaluated using the micromechanically-determined elastic constants and experimentally evaluated strut modulus. These results indicate that the multi-scale approach of linking micromechancial modelling of the sintered scaffold material with macroscale modelling gives an accurate prediction of the mechanical behaviour of the sintered structure.Keywords: selective laser sintering; polycaprolactone, B-tricalcium phosphate; micromechanical modelling; bone tissue engineering; mechanical properties; finite element analysis.3 IntroductionThe purpose of bone tissue engineering scaffolds is to fill defects and support mechanical loading while providing a template on which new bone will form. The remodelling of native bone in response to mechanical loading occurs when cells convert mechanical stimuli to chemical signals to direct the formation of new tissue or resorption through mechanotransduction 30,44 . The mechanical stimuli that influence bone formation in vivo are a combination of both fluid shear over the cells 36,55 and mechanical loading of the cells 16,24,58 , therefore it is important to be able to acc...

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Section: Meanmentioning

confidence: 99%

“…Therefore, the first type of material assignment used was homogeneous assignment of isotropic linear elastic properties of PCL: ν = 0.3 13 , and E PCL determined from pure PCL tensile testing (Section 4.1.1). It should be noted that this method is not representative of the real material and is only intended as a comparison.…”

Section: Pcl Modelsmentioning

confidence: 99%

Predicting the Elastic Properties of Selective Laser Sintered PCL/β-TCP Bone Scaffold Materials Using Computational Modelling

2013

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“…However, it has been shown that loading ceramics up to 30 % with polymer composites can improve their mechanical properties [17]. FE modelling of mechanical properties can be seen as an effective tool in computational design and direct digital manufacture of patient-and site-specific composite tissue-engineering constructs with tailored properties [18].…”

Section: Introductionmentioning

confidence: 99%

Powder bed generation in integrated modelling of additive layer manufacturing of orthopaedic implants

Krzyżanowski

Svyetlichnyy

Stevenson

et al. 2016

Int J Adv Manuf Technol

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This paper presents an original model of powder bed generation developed within the frame of an integrated modelling approach for studying the interaction of physical mechanisms in additive layer manufacturing (ALM) of orthopaedic implants. The model is based on cellular automata (CA) approach and describes the relationship between moving particles of different sizes during deposition on a surface in three dimensions. The surface is defined by the horizontal two-dimensional CA on which particles fall and irreversibly stick to a growing deposit. The model allows for consideration of different restructuring cases when particles are allowed to rotate as often as necessary until achievement of a local minimum position. Changes in the packing density of the powder bed have been investigated numerically depending on technological parameters, such as particle size distribution, deposition rate and sequence of powder deposition. The model has been developed with the aim of merging to the finite element (FE)-based integrated model and is applicable to a different ranges of materials including metals and also non-metals.

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“…Poly-ε-caprolactone (PCL) is a translucent polyester that has a strength of about 0.4 GPa (Eshraghi, Das, 2010), which is regarded as an outstanding synthetic biodegradable polymer.…”

mentioning

confidence: 99%

Properties and Biocompatibility of Poly-3- Hydroxybutyrate-co-3-Hydroxyvalerate/Poly-ε- Caprolactone Blends

Boyandin¹,

Nikolaeva²,

Sukovatiy³

2016

J. Sib. Fed. Univ., Biol.

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Blends consisting of the poly-3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV) copolymer and poly-ε-caprolactone (PCL) were used to prepare polymer films by casting solution technique. The structure and physical-mechanical, and biological properties of the films were examined as influenced by DOI: 10.17516/1997DOI: 10.17516/ -1389DOI: 10.17516/ -2015 поли-3-гидроксибутират-3-гидроксивалерат, поли-ε-капролактон, смеси полимеров, биополимеры, биосовместимость.

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Mechanical and microstructural properties of polycaprolactone scaffolds with one-dimensional, two-dimensional, and three-dimensional orthogonally oriented porous architectures produced by selective laser sintering

Cited by 434 publications

References 78 publications

Predicting the Elastic Properties of Selective Laser Sintered PCL/β-TCP Bone Scaffold Materials Using Computational Modelling

Predicting the Elastic Properties of Selective Laser Sintered PCL/β-TCP Bone Scaffold Materials Using Computational Modelling

Powder bed generation in integrated modelling of additive layer manufacturing of orthopaedic implants

Properties and Biocompatibility of Poly-3- Hydroxybutyrate-co-3-Hydroxyvalerate/Poly-ε- Caprolactone Blends

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