Mechanical and in vivo performance of hydroxyapatite implants with controlled architectures

Chu, Tien Min G.; Orton, David G.; Hollister, Scott J.; Feinberg, Stephen E.; Halloran, John W.

doi:10.1016/s0142-9612(01)00243-5

Cited by 485 publications

(273 citation statements)

References 24 publications

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“…In the case of bio-inert materials, porosity and pore size generally do not affect osteogenesis, but with regard to bioactive materials, porosity and pore size significantly influence osteogenesis [47][48][49]. It is pertinent to keep in mind that porosity is not the cause for hypoxia, which is considered responsible for encouraging osteochondral ossification [1,50].…”

Section: Design Considerationsmentioning

confidence: 99%

Advancements in three-dimensional titanium alloy mesh scaffolds fabricated by electron beam melting for biomedical devices: mechanical and biological aspects

Nune

Misra

2017

Sci. China Mater.

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We elucidate here the process-structure-property relationships in three-dimensional (3D) implantable titanium alloy biomaterials processed by electron beam melting (EBM) that is based on the principle of additive manufacturing. The conventional methods for processing of biomedical devices including freeze casting and sintering are limited because of the difficulties in adaptation at the host site and difference in the micro/macrostructure, mechanical, and physical properties with the host tissue. In this regard, EBM has a unique advantage of processing patient-specific complex designs, which can be either obtained from the computed tomography (CT) scan of the defect site or through a computeraided design (CAD) program. This review introduces and summarizes the evolution and underlying reasons that have motivated 3D printing of scaffolds for tissue regeneration. The overview comprises of two parts for obtaining ultimate functionalities. The first part focuses on obtaining the ultimate functionalities in terms of mechanical properties of 3D titanium alloy scaffolds fabricated by EBM with different characteristics based on design, unit cell, processing parameters, scan speed, porosity, and heat treatment. The second part focuses on the advancement of enhancing biological responses of these 3D scaffolds and the influence of surface modification on cell-material interactions. The overview concludes with a discussion on the clinical trials of these 3D porous scaffolds illustrating their potential in meeting the current needs of the biomedical industry.

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Section: Design Considerationsmentioning

confidence: 99%

Advancements in three-dimensional titanium alloy mesh scaffolds fabricated by electron beam melting for biomedical devices: mechanical and biological aspects

Nune

Misra

2017

Sci. China Mater.

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“…[5][6][7][8] First, experiments with sacrificial RP molds 3 have shown that composite materials can be molded, but that further investigations are necessary to improve the feature resolution of the final RP part and to decrease the time necessary for the fabrication. With wax-based processes especially (e.g., Solidscape Modelmaker), the build duration for more complex structures can reach impractical values.…”

Section: State Of the Art: Rapid Prototyping (Rp) Of Cellular Materialsmentioning

confidence: 99%

Water‐soluble photopolymers for rapid prototyping of cellular materials

Liska

Schwager

Maier

et al. 2005

J of Applied Polymer Sci

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Commercial light-sensitive resins for Rapid Prototyping of cellular materials are often unsuitable for different molding techniques because removal of the mold uses thermal decomposition at temperatures of up to 600°C. In this study, a resin formulation based on water-soluble polymers was developed and evaluated regarding its usability as sacrificial mold material. The base monomer dimethylacrylamide gave fast curing and excellent polymer solubility. Methacrylic acid was found to be a useful comonomer to improve mechanical strength and feature resolution. The latter criterion was also improved by adding poly(vinyl pyrrolidone) as filler and by using a hydrolytically cleavable crosslinking agent such as methacrylic acid anhydride.

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“…Tissue engineering efforts are faced with challenges including the availability of cells to be used for engineering specific tissue (Chu et al, 2002). Another challenge in tissue engineering is the availability of biocompatible, biodegradable scaffolds that enhance cell adhesion as well as cell proliferation and matrix production.…”

Section: Introductionmentioning

confidence: 99%

Low Intensity Pulsed Ultrasound: A Laboratory and Clinical Promoter in Tissue Engineering Abstract

El‐Bialy¹

2010

Tissue Engineering

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This chapter will focus on the current and future applications of low intensity pulsed ultrasound (LIPUS) in tissue engineering at laboratory and clinical levels. Also, this chapter will explain the molecular basis of LIPUS stimulatory effects on cell expansion, differentiation and matrix production of different tissues. In addition, this chapter will provide information about the differences between LIPUS application in the laboratory settings and in the clinical applications with emphasis on tissue engineering applications. Moreover, this chapter will discuss why variability in outcome might occur when applying LIPUS in laboratory or clinical settings. Also, we will provide some tips on how to prevent potential inconsistency in treatment results with emphasis on the technique sensitivity and how a scientist or a clinician should be aware of this sensitivity of the application technique in order to optimize the utilization of LIPUS in different settings. This chapter will set a few hypotheses and potential new applications of utilizing LIPUS in other tissue engineering applications. The outcome of this chapter will be an understanding of the advantages and limitations of using LIPUS in tissue engineering applications either at the laboratory or in clinical settings.

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Mechanical and in vivo performance of hydroxyapatite implants with controlled architectures

Cited by 485 publications

References 24 publications

Advancements in three-dimensional titanium alloy mesh scaffolds fabricated by electron beam melting for biomedical devices: mechanical and biological aspects

Advancements in three-dimensional titanium alloy mesh scaffolds fabricated by electron beam melting for biomedical devices: mechanical and biological aspects

Water‐soluble photopolymers for rapid prototyping of cellular materials

Low Intensity Pulsed Ultrasound: A Laboratory and Clinical Promoter in Tissue Engineering Abstract

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