Mechanical and cold hypersensitivity in nerve-injured C57BL/6J mice is not associated with fear-avoidance- and depression-related behaviour

Hasnie, F.; Wallace, Victoria C.J.; Hefner, Kathryn R.; Holmes, Andrew; Rice, Alistair

doi:10.1093/bja/aem087

Cited by 53 publications

(40 citation statements)

References 24 publications

(32 reference statements)

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“…Using pain models such as virally induced neuropathy [27], drug-induced toxic neuropathy [27,28], nerve injury-induced neuropathy [21,23,25,34,35] or models mimicking arthritic pain [21,36,37], studies have shown that the development of pain influenced the onset of anxiety-like behaviors in rodents. The use of one or two behavioral tests in the experimental designs of these studies is, however, a salient feature to be addressed.…”

Section: Discussionmentioning

confidence: 99%

“…Of course, one could argue that this may only be due to interspecies differences, since variability among strains has been reported. For instance, Hasnie et al [34] found that male C57BL/6J mice subjected to partial sciatic nerve ligation do not exhibit anxiety-related behaviors in the EPM. In opposition, nerve-injured mice sharing the same genetic background were shown to develop anxiety-like phenotypes in the same behavioral paradigm by a different group [21].…”

Section: Discussionmentioning

confidence: 99%

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Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain

Parent

Beaudet

Beaudry

et al. 2012

Behavioural Brain Research

119

111

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For many patients, chronic pain is often accompanied, and sometimes amplified, by co-morbidities such as anxiety and depression. Although it represents important challenges, the establishment of appropriate preclinical behavioral models contributes to drug development for treating chronic inflammatory pain and associated psychopathologies. In this study, we investigated whether rats experiencing persistent inflammatory pain induced by intraplantar injection of complete Freund's adjuvant (CFA) developed anxiety-like behaviors, and whether clinically used analgesic and anxiolytic drugs were able to reverse CFA-induced anxiety-related phenotypes. These behaviors were evaluated over 28 days in both CFA-and saline-treated groups with a variety of behavioral tests. CFA-induced mechanical allodynia resulted in increased anxiety-like behaviors as evidenced by: 1) a significant decrease in percentage of time spent and number of entries in open arms of the elevated-plus maze (EPM), 2) a decrease in number of central squares visited in the open field (OF), and 3) a reduction in active social interactions in the social interaction test (SI). The number of entries in closed arms in the EPM and the distance travelled in the OF used as indicators of locomotor performance did not differ between treatments. Our results also reveal that in CFAtreated rats, acute administration of morphine (3 mg/kg, s.c.) abolished tactile allodynia and anxiety-like behaviors, whereas acute administration of diazepam (1 mg/kg, s.c) solely reversed anxiety-like behaviors. Therefore, pharmacological treatment of anxiety-like behaviors induced by chronic inflammatory pain can be objectively evaluated using multiple behavioral tests. Such a model could help identify/validate alternative potential targets that influence pain and cognitive dimensions of anxiety.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain

Parent

Beaudet

Beaudry

et al. 2012

Behavioural Brain Research

119

111

View full text Add to dashboard Cite

show abstract

“…However, although most studies find that depression-like behaviors are observed in animal models of neuropathic pain, there are exceptions. For example, PSNL did not induce depression-like behavior as measured by TST up to 4 weeks after surgery [52]. In another study, L5-6 nerve ligated rats did not demonstrate depression-like behavior as measured by FST 2 weeks after the surgery [53].…”

Section: Animal Studies Of the Pain-depression Relationshipmentioning

confidence: 99%

“…Although pain hypersensitivity after nerve injury develops quickly, depression-like behavior is time-dependent and develops much slower (usually weeks after the primary injury) [54]. For instance, Hasnie et al did not observe changes in the TST test in PSNL-injured mice 4 weeks later [52], but another study observed significant increased immobility in TST in mice 7 weeks after the same injury [49]. Our own unpublished observation was that rats with CCI surgery developed significant depression-like behavior in the FST at least 4 weeks after the surgery.…”

Section: Animal Studies Of the Pain-depression Relationshipmentioning

confidence: 99%

Pain and depression comorbidity: A preclinical perspective

2015

Behavioural Brain Research

140

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Pain and depression are two highly prevalent and deleterious disorders with significant socioeconomic impact to society. Clinical observations have long recognized the co-existence and interactions of pain and depression. However, the underlying mechanisms of pain-depression comorbidity and their dynamic interactions remain largely unknown. Preclinical animal studies may provide critical information for the understanding of this important comorbidity. This review analyzed the current preclinical evidence of interactions between pain and depression, which generally supports the causative relationship of the two conditions. In addition, the analysis proposed to apply domain interplay concept in future model development of pain-depression comorbidity and mechanism studies. The application of spectrum-centered animal models will better the understanding of pain-depression dyad and foster the development of more effective therapeutic strategies.

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“…Differences in protocols, measurements and laboratory procedures can lead to wide variability in results, or no effect seen at all [61; 73]. In addition, data must be interpreted in terms of the animals’ normal behavioral repertoire and anthropomorphism should be avoided.…”

Section: Pain Co-morbidities In Rodents: Increased Anxiety Depresmentioning

confidence: 99%

Effect of environment on the long-term consequences of chronic pain

Bushnell¹,

Case²,

Čeko³

et al. 2015

Pain

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Much evidence from pain patients and animal models shows that chronic pain does not exist in a vacuum, but has varied co-morbidities and far-reaching consequences. Patients with long-term pain often develop anxiety and depression and can manifest changes in cognitive functioning, particularly with working memory. Longitudinal studies in rodent models also show the development of anxiety-like behavior and cognitive changes weeks to months after an injury causing long-term pain. Brain imaging studies in pain patients and rodent models find that chronic pain is associated with anatomical and functional alterations in the brain. Nevertheless, studies in humans reveal that life-style choices, such as the practice of meditation or yoga, can reduce pain perception and have the opposite effect on the brain as does chronic pain. In rodent models, studies show that physical activity and a socially enriched environment reduce pain behavior and normalize brain function. Together, these studies suggest that the burden of chronic pain can be reduced by non-pharmacological interventions.

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Mechanical and cold hypersensitivity in nerve-injured C57BL/6J mice is not associated with fear-avoidance- and depression-related behaviour

Abstract: These data demonstrate that pain behaviour in nerve-injured C57BL/6J mice was not associated with alterations in emotion-related behaviours.

Cited by 53 publications

References 24 publications

Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain

Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain

Pain and depression comorbidity: A preclinical perspective

Effect of environment on the long-term consequences of chronic pain

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