Pain and depression comorbidity: A preclinical perspective

Li, Jun-Xu

doi:10.1016/j.bbr.2014.04.042

Cited by 140 publications

(101 citation statements)

References 78 publications

(109 reference statements)

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“…For example, previous clinical investigations have observed frequent comorbidity of pain and depression [47-49]. Not only do these two symptoms coexist, they often respond to the same treatment and exacerbate each other [17]. In addition to pain, urinary dysfunction has also been reported to be correlated with severity of depression [50].…”

Section: Discussionmentioning

confidence: 99%

Co-Occurring Symptoms Contribute to Persistent Fatigue in Prostate Cancer

et al. 2019

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Purpose: Cancer-related fatigue is one of the most debilitating side effects of cancer and cancer therapy. We aimed to investigate co-occurring symptoms associated with persistent fatigue in men receiving external beam radiation therapy (EBRT) for nonmetastatic prostate cancer. Methods: A sample of 47 men with prostate cancer scheduled to receive radiotherapy (RT) were followed at baseline and 1 year after RT. Clinical and demographic data were obtained from chart review. Symptom measurements included urinary dysfunction (American Urological Association symptoms score), fatigue (Functional Assessment of Cancer Therapy – Fatigue questionnaire), sleep disturbance (Patient-Reported Outcomes Measurement Information System – Sleep Disturbance form), pain (physical well-being domain pain item of the Functional Assessment of Cancer Therapy – General), and depressive symptoms (Hamilton Depression Rating Scale). Paired t tests, correlations, general linear models, and logistic regressions were used to determine associations between fatigue and other symptom scores. Results: At 1 year after RT, 34% of subjects continued to experience fatigue. Urinary dysfunction was the best clinical predictor of persistent fatigue. Pain and depressive symptoms further improved the predictive power of the model. A multivariate linear regression model containing all these three clinical variables (urinary dysfunction, pain, and depressive symptoms) explained 74% of total variance associated with persistent fatigue after RT. Conclusions: Persistent fatigue at 1 year after EBRT in prostate cancer survivors is likely related to a cluster of symptoms elicited by chronic inflammation. Therapies that target each of these symptoms will likely reduce fatigue in this patient population.

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Section: Discussionmentioning

confidence: 99%

Co-Occurring Symptoms Contribute to Persistent Fatigue in Prostate Cancer

et al. 2019

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“…Pain and depression frequently manifest together. Epidemiological studies have shown that the prevalence of depression in patients with pain is higher compared with that when these two conditions are separately evaluated [1][2][3]. Approximately 30% of patients in pain experience depression [4,5].…”

Section: Introductionmentioning

confidence: 99%

Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury

Fang

Yang

et al. 2018

Eur Arch Psychiatry Clin Neurosci

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Although depressive symptoms including anhedonia (i.e., loss of pleasure) frequently accompany pain, little is known about the risk factors contributing to individual differences in pain-induced anhedonia. In this study, we examined if signaling of brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-receptor-kinase B (TrkB) contribute to individual differences in the development of neuropathic pain-induced anhedonia. Rats were randomly subjected to spared nerved ligation (SNI) or sham surgery. The SNI rats were divided into two groups based on the results of a sucrose preference test. Rats with anhedonia-like phenotype displayed lower tissue levels of BDNF in the medial prefrontal cortex (mPFC) compared with rats without anhedonia-like phenotype and sham-operated rats. In contrast, tissue levels of BDNF in the nucleus accumbens (NAc) of rats with an anhedonia-like phenotype were higher compared with those of rats without anhedonia-like phenotype and sham-operated rats. Furthermore, tissue levels of BDNF in the hippocampus, L2-5 spinal cord, muscle, and liver from both rats with or without anhedonia-like phenotype were lower compared with those of sham-operated rats. A single injection of 7,8-dihydroxyflavone (10 mg/kg; TrkB agonist), but not ANA-12 (0.5 mg/kg; TrkB antagonist), ameliorated reduced sucrose preference and reduced BDNF-TrkB signaling in the mPFC in the rats with anhedonia-like phenotype. These findings suggest that reduced BDNF-TrkB signaling in the mPFC might contribute to neuropathic pain-induced anhedonia, and that TrkB agonists could be potential therapeutic drugs for pain-induced anhedonia.

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“…Depression, in turn, is conducive to intensification of pain (cf. Li, 2015;Wojtyna, 2012), as well as cognitive distortions, consisting of negative perception of self, reality, and the future, thus it may be directly connected with reduction of hope (cf. Williams, 1997;Wójcik & Wojtyna, 2008).…”

Section: Discussionmentioning

confidence: 99%

From Polyanna syndrome to Eeyore’s Corner? Hope and pain in patients with chronic low back pain

Wojtyna¹,

Palt²,

Popiołek³

2015

Polish Psychological Bulletin

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Chronic low back pain affects 50-80% of the population, while its consequences may impair the functioning of patients suffering from it, in many spheres of life . Hope is a factor which may influence coping with pain as well as cognitive reflection of pain experience. The aim of the study has been to check: 1) whether dependencies exist between hope-trait and hope-state and the perception of pain; 2) whether experiencing pain at the time of filling questionnaires matters for the assessment of the level of hope; 3) whether there is interaction between hope, the pain experienced at the moment of investigation, and memory of the intensity of previously experienced pain. 150 patients participated in the study, they all reported aggravation of the chronic low back pain syndrome. The study was a cross-sectional study, based on questionnaires. On the third day of treatment the subjects were given the following questionnaires: Trait Hope Scale, State Hope Scale, and Numerical Rating Scale of Pain to fill. Poor correlation was demonstrated to exist between hope-state and hope-pathways on the one hand, and the intensity of minimum pain level experienced during the first three days of treatment. It has been noted that the presence of pain at the time of filling questionnaires results in reducing the hope-state, but only in those persons, who had experienced severe pain previously. On the other hand, in case of patients who had experienced slight pain previously, the pain present when filling in the questionnaires is conducive to enhanced hope-state. The results of the study confirm the complex character of relations between hope and pain.

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Pain and depression comorbidity: A preclinical perspective

Cited by 140 publications

References 78 publications

Co-Occurring Symptoms Contribute to Persistent Fatigue in Prostate Cancer

Co-Occurring Symptoms Contribute to Persistent Fatigue in Prostate Cancer

Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury

From Polyanna syndrome to Eeyore’s Corner? Hope and pain in patients with chronic low back pain

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