Measuring flow dynamics in a microfluidic chip using optical coherence tomography with 1 µm axial resolution

Lauri, Janne; Czajkowski, Jakub; Myllylä, Risto; Fabritius, Tapio

doi:10.1016/j.flowmeasinst.2015.02.001

Cited by 15 publications

(12 citation statements)

References 36 publications

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“…Here, a laboratory-built spectral domain DOCT device was used; the detailed device description can be found in refs. [24,25]. This device has an axial resolution of 0.9 µm in water.…”

Section: Methodsmentioning

confidence: 99%

Rheological and Flocculation Analysis of Microfibrillated Cellulose Suspension Using Optical Coherence Tomography

et al. 2018

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A sub-micron resolution optical coherence tomography device was used together with a pipe rheometer to analyze the rheology and flocculation dynamics of a 0.5% microfibrillated cellulose (MFC) suspension. The bulk behavior of the MFC suspension showed typical shear thinning (power-law) behavior. This was reflected in a monotonously decreasing floc size when the shear stress exceeded the yield stress of the suspension. The quantitative viscous behavior of the MFC suspension changed abruptly at the wall shear stress of 10 Pa, which was reflected in a simultaneous abrupt drop of the floc size. The flocs were strongly elongated with low shear stresses. With the highest shear stresses, the flocs were almost spherical, indicating a good level of fluidization of the suspension.

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“…Here, a laboratory-built spectral domain DOCT device was used; the detailed device description can be found in refs. [24,25]. This device has an axial resolution of 0.9 µm in water.…”

Section: Methodsmentioning

confidence: 99%

Rheological and Flocculation Analysis of Microfibrillated Cellulose Suspension Using Optical Coherence Tomography

et al. 2018

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“…The laboratory-built spectral domain OCT device 17,18 employs an integrated supercontinuum light source (SuperK Extreme EXB-1, NKT Photonics). The spectrum range from 450 to 800 nm was used for imaging.…”

Section: Methodsmentioning

confidence: 99%

Quantification of cell-free layer thickness and cell distribution of blood by optical coherence tomography

2016

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Abstract. A high-speed optical coherence tomography (OCT) with 1-μm axial resolution was applied to assess the thickness of a cell-free layer (CFL) and a spatial distribution of red blood cells (RBC) next to the microchannel wall. The experiments were performed in vitro in a plain glass microchannel with a width of 2 mm and height of 0.2 mm. RBCs were suspended in phosphate buffered saline solution at the hematocrit level of 45%. Flow rates of 0.1 to 0.5 ml∕h were used to compensate gravity induced CFL. The results indicate that OCT can be efficiently used for the quantification of CFL thickness and spatial distribution of RBCs in microcirculatory blood flow.

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“…The usefulness of DOCT velocity measurements has been demonstrated for pressure-driven flows in microchannels of various sizes and geometries (Proskurin et al, 2003b;Bukowska et al, 2013;Lauri et. al., 2015).…”

Section: Microfluidicsmentioning

confidence: 99%

Analysis of Industry-Related Flows by Optical Coherence Tomography—A Review

Koponen

Haavisto²

2020

KONA

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Optical Coherence Tomography (OCT) is a light-based imaging method capable of simultaneously capturing the internal structure and motion (1D, 2D or 3D) of various opaque and turbid materials with a micron-level spatial resolution. Depending on the OCT technology, axial scanning rates can vary in a range of tens to hundreds of kHz. The actual imaging depth significantly depends on the optical properties of the material and can vary from micrometers to a few millimeters. From the viewpoint of industrial applications, OCT technology is very appealing. Due to its resolution, speed, and ability to deal with opaque materials, it fills an apparent gap in available measurement methods. Nonetheless, OCT has not to date seen widespread growth in the industrial field. This has been at least partly due to a lack of commercial devices compact and flexible enough to adapt to industrial needs. The recent emergence of more generic commercial OCT devices has considerably lowered the threshold for adapting the technique. The utilization of OCT for structural analysis, also outside the medical field, has been thoroughly discussed in scientific literature. Therefore, in this paper, we will mainly concentrate on applications of OCT that also utilize its capability of performing velocity measurements. The emphasis will be on industrially motivated problems such as rheology, microfluidics, fouling and turbulence.

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Measuring flow dynamics in a microfluidic chip using optical coherence tomography with 1 µm axial resolution

Cited by 15 publications

References 36 publications

Rheological and Flocculation Analysis of Microfibrillated Cellulose Suspension Using Optical Coherence Tomography

Rheological and Flocculation Analysis of Microfibrillated Cellulose Suspension Using Optical Coherence Tomography

Quantification of cell-free layer thickness and cell distribution of blood by optical coherence tomography

Analysis of Industry-Related Flows by Optical Coherence Tomography—A Review

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