Measuring change in dry‐mouth symptoms over time using the Xerostomia Inventory

Thomson, W. Murray

doi:10.1111/j.1741-2358.2007.00137.x

Cited by 90 publications

(71 citation statements)

References 10 publications

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“…The minimally important difference was determined for the Summated Xerostomia Inventory-Dutch Version using the New Zealand community sample (the data for which were part of a longitudinal study used in determining the minimally important difference for the original XI 13 ). It was found to be 4, indicating that a deterioration in Summated Xerostomia Inventory-Dutch Version scale score by 4 or more scale points can be considered to be clinically meaningful.…”

Section: Resultsmentioning

confidence: 99%

“…Work with the longitudinal data-set used in the New Zealand sample enabled determination of the minimally important difference for changes in scores over time, as was done for the longer measure. 13 It was 6 for the latter and 4 for the new version, reflecting the change in scoring. That an increase in score of 4 points appears to be clinically meaningful requires replication in other studies and settings.…”

Section: Discussionmentioning

confidence: 99%

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Shortening the Xerostomia Inventory

Thomson¹,

Putten²,

Baat³

et al. 2011

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

142

120

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Objectives To determine the validity and properties of the Summated Xerostomia Inventory-Dutch Version in samples from Australia, The Netherlands, Japan and New Zealand. Study design Six cross-sectional samples of older people from The Netherlands (N = 50), Australia (N = 637 and N = 245), Japan (N = 401) and New Zealand (N = 167 and N = 86). Data were analysed using the Summated Xerostomia Inventory-Dutch Version. Results Almost all data-sets revealed a single extracted factor which explained about half of the variance, with Cronbach’s alpha values of at least 0.70. When mean scale scores were plotted against a “gold standard” xerostomia question, statistically significant gradients were observed, with the highest score seen in those who always had dry mouth, and the lowest in those who never had it. Conclusion The Summated Xerostomia Inventory-Dutch Version is valid for measuring xerostomia symptoms in clinical and epidemiological research.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Shortening the Xerostomia Inventory

Thomson¹,

Putten²,

Baat³

et al. 2011

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

142

120

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“…Xerostomia Inventory (XI) measures xerostomia with acceptable reliability, validity and responsiveness . This 11‐item inventory has adequate responsiveness to assess outcomes related to therapies including medications . It was also found to be related to oral health‐related quality of life .…”

Section: Introductionmentioning

confidence: 99%

Should short‐term use of alcohol‐containing mouthrinse be avoided for fear of worsening xerostomia?

Nair

Chiu

Chua

et al. 2017

J of Oral Rehabilitation

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This study aimed to assess the short-term effect of alcohol-containing mouthrinse versus mouthrinse without alcohol on xerostomia scores reported by Xerostomia Inventory (XI) scores and short version of the Xerostomia Inventory (SXI). This study was a two-group parallel-arm randomised controlled trial where participants were randomly allocated to twice a day for 7 days use of either alcohol-containing or alcohol-free mouthrinse. Allocation was concealed. The participants, the outcome assessors and the statistician were blinded to the allocation status. A total of 163 participants completed the pre-and post-intervention data collection. There were no statistically significant differences between the study groups with respect to demographics or other measured independent variables. After adjusting for age and gender, regression coefficient (95% CI) for XI was 0.02 (-1.72-2.29) and that for SXI was 0.03 (-0.54-0.83). Both adjusted and unadjusted models showed no significant differences in change in XI or SXI. The mean difference in scores between the groups for XI was -0.45 (-2.45-1.55) and for SXI was 0.05 (-0.65-0.75). There was no significant difference in the change in xerostomia levels as a result of short-term exposure to alcohol-containing mouthrinse, when compared to those exposed to alcohol-free mouthrinse. Short-term use of alcohol-containing mouthrinse does not result in worsening xerostomia.

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“…In this regard, and apart from the use of a previously validated questionnaire 1 rather than the recently published xerostomia inventory, 19 we used validated tools (eg, 10-cm-long VAS and 4-point ordinal scale) and a validated cutoff of salivary flow rate to relevantly identify and enroll patients with dry mouth for the purpose of the current clinical trial. In this regard, and apart from the use of a previously validated questionnaire 1 rather than the recently published xerostomia inventory, 19 we used validated tools (eg, 10-cm-long VAS and 4-point ordinal scale) and a validated cutoff of salivary flow rate to relevantly identify and enroll patients with dry mouth for the purpose of the current clinical trial.…”

Section: Discussionmentioning

confidence: 99%

Meeting Announcement

2007

Journal of Clinical Psychopharmacology

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Objective: Xerostomia is a subjective sensation of mouth dryness often occurring as an unwanted effect of psychotropic drugs. Methods: The clinical efficacy and acceptability of a new oxygenated glycerol triester (OGT) oral spray (1 or 2 sprays up to 4 times daily) in the treatment of xerostomia was compared with those of a commercially available artificial saliva substitute (ASS [Saliveze]) in a 2-week, open-labeled, randomized, parallel-group study. Clinical assessment of xerostomia included evaluation of mouth dryness by means of a 10-cm-long visual analog scale, objective blinded assessment of the oral tissue condition by a dental hygienist by means of a 4-point ordinal scale, and subjective patient-based assessment of dry mouth symptoms by means of dichotomous responses to a questionnaire. [Day 14 j baseline] patient-based mouth dryness score was the primary end point. Results: Seventy-four patients (41 women and 33 men, 44 T 15 years) undergoing long-term psychotropic drug treatment were consecutively enrolled. At day 14, OGT resulted in better efficacy than ASS in mouth dryness score (mean difference, 1.2 T 0.4; P = 0.006), speech difficulties (mean difference, 1.2 T 0.4; P = 0.005), taste (mean difference, 1.1 T 0.4; P = 0.02), and overall mouth condition (mean difference, 1.4 T 0.9; P = 0.005). Taste of OGT was better than that of ASS (mean difference, 1.4 T 0.6; P = 0.04), as was OGT acceptability (mean difference, 1.4 T 0.9; P = 0.005). Conclusion: Oxygenated glycerol triester lubricant oral spray was superior to a commercially available ASS in improving xerostomia and overall condition of the oral tissue. (J Clin Psychopharmacol 2007;27:437-443)

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Measuring change in dry‐mouth symptoms over time using the Xerostomia Inventory

Abstract: The validity and responsiveness of the XI appear to be acceptable, and a change in XI score of 6 or more points is clinically meaningful.

Cited by 90 publications

References 10 publications

Shortening the Xerostomia Inventory

Shortening the Xerostomia Inventory

Should short‐term use of alcohol‐containing mouthrinse be avoided for fear of worsening xerostomia?

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