Measurements of body fat distribution: assessment of collinearity with body mass, adiposity and height in female adolescents

Pereira, Patrícia Feliciano; Serrano, Hiara Miguel Stanciola; Carvalho, Gisele Queiroz; Ribeiro, Sônia Machado Rocha; Pelúzio, Maria do Carmo Gouveia; Franceschini, Sylvia do Carmo Castro; Priore, Sílvia Eloíza

doi:10.1016/s2359-3482(15)30032-4

Cited by 13 publications

(18 citation statements)

References 22 publications

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“…Given the established correlation between total body fat percentage and WHR (R-0.052 to 0.483) 39–41 , we examined the association of our top exome variants with both total body fat percentage (BF%) and truncal fat percentage (TF%) available in a sub-sample of up to 118,160 participants of UKBB (Supplementary Tables 10-11) . Seven of the common novel variants were significantly associated (P<0.001, 0.05/48 variants examined) with both BF% and TF% in the sexes-combined analysis ( COBLL1, UHRF1BP1, WSCD2, CCDC92, IFI30, MPV17L2, IZUMO1) .…”

Section: Resultsmentioning

confidence: 99%

Protein-Coding Variants Implicate Novel Genes Related to Lipid Homeostasis Contributing to Body Fat Distribution

Justice¹,

Karaderi²,

Highland³

et al. 2018

Preprint

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Body fat distribution is a heritable risk factor for a range of adverse health consequences, including hyperlipidemia and type 2 diabetes. To identify protein-coding variants associated with body fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, we analyzed 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries for discovery and 132,177 independent European-ancestry individuals for validation. We identified 15 common (minor allele frequency, MAF≥5%) and 9 low frequency or rare (MAF<5%) coding variants that have not been reported previously. Pathway/gene set enrichment analyses of all associated variants highlight lipid particle, adiponectin level, abnormal white adipose tissue physiology, and bone development and morphology as processes affecting fat distribution and body shape. Furthermore, the cross-trait associations and the analyses of variant and gene function highlight a strong connection to lipids, cardiovascular traits, and type 2 diabetes. In functional follow-up analyses, specifically in Drosophila RNAi-knockdown crosses, we observed a significant increase in the total body triglyceride levels for two genes (DNAH10 and PLXND1). By examining variants often poorly tagged or entirely missed by genome-wide association studies, we implicate novel genes in fat distribution, stressing the importance of interrogating low-frequency and protein-coding variants.

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Section: Resultsmentioning

confidence: 99%

Protein-Coding Variants Implicate Novel Genes Related to Lipid Homeostasis Contributing to Body Fat Distribution

Justice¹,

Karaderi²,

Highland³

et al. 2018

Preprint

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show abstract

“…Pereira e Serrano et al (2015) [20] , in a study performed with girls aged 14-19, observed that C index was not a good indicator of body mass and total body fat. Pelegrini et al (2015) [2] found that C index had a lower ability to discriminate body fat in adolescents.…”

Section: Discussionmentioning

confidence: 97%

“…The C index may not be a good anthropometric indicator of fat in the trunk in children and adolescents, probably because the relationships between the measures are not good indicators of obesity. [20] Furthermore, the distribution of body fat differs between genders. The reserve of adipose tissue in women to be accumulates predominantly in the gluteo-femoral region, while in men in the central region.…”

Section: Discussionmentioning

confidence: 99%

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Anthropometric Measures in the Prediction of High Fat Percentage in Female Adolescents

2017

International Journal of Research Studies in Biosciences

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Abstract:Objective: This study aimed to evaluate the predictive power of anthropometric indices for the diagnosis of high fat mass in female adolescents. Subjects/Methods: This is a cross-sectional study with a sample of 233 students female, aged 10-19 years, from 16 public schools of São Luís (Maranhão State, Brazil). The following indicators were assessed: body mass index (BMI), waist circumference (WC), conicity index (C-index), and the waist-to-height ratio (WHtR

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“…La inclusión de esta variable antropométrica podría conducir a una adecuada clasificación del exceso de peso en niños y adolescentes. Aunque es necesario confrontar estos resultados con métodos de laboratorio sofisticados como la absorciometría de rayos X de doble energía (DXA), el cual permite valorar con precisión la grasa visceral abdominal 21 .…”

Section: Discussionunclassified

Predictores de los Indicadores de adiposidad corporal por edad cronológica y biológica en niños y adolescentes que residen en el sur de Chile

Alvear

Gómez-Campos

Urra-Albornoz

et al. 2017

Rev Esp Nutr Hum Diet

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[ahead of print]Freely available online -OPEN ACCESS La Revista Española de Nutrición Humana y Dietética se esfuerza por mantener a un sistema de publicación continua, de modo que los artículos se publican antes de su formato final (antes de que el número al que pertenecen se haya cerrado y/o publicado). De este modo, intentamos poner los artículos a disposición de los lectores/usuarios lo antes posible.The Spanish Journal of Human Nutrition and Dietetics strives to maintain a continuous publication system, so that the articles are published before its final format (before the number to which they belong is closed and/or published). In this way, we try to put the articles available to readers/users as soon as possible. Revista Española de Nutrición

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Measurements of body fat distribution: assessment of collinearity with body mass, adiposity and height in female adolescents

Cited by 13 publications

References 22 publications

Protein-Coding Variants Implicate Novel Genes Related to Lipid Homeostasis Contributing to Body Fat Distribution

Protein-Coding Variants Implicate Novel Genes Related to Lipid Homeostasis Contributing to Body Fat Distribution

Anthropometric Measures in the Prediction of High Fat Percentage in Female Adolescents

Predictores de los Indicadores de adiposidad corporal por edad cronológica y biológica en niños y adolescentes que residen en el sur de Chile

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