Measurement properties of the Arm Function in Multiple Sclerosis Questionnaire (AMSQ): a study based on Classical Test Theory

Abstract

The AMSQ shows satisfying results for validity and excellent reliability; allowing for proper use in research. Due to a large SDC value, caution is needed when using the AMSQ in individual patient care. Further research should determine whether the SDC is smaller than the minimal important change. Implications for Rehabilitation The Arm Function in Multiple Sclerosis Questionnaire (AMSQ) measures activity limitations due to hand and arm functioning in patients with Multiple Sclerosis (MS). Results of this study confirm adequate validity and reliability of the AMSQ in patient with MS. The equivalence of scores from online, paper or interview administration is supported. A change score of ≥18 points on the scale of the AMSQ (on a scale 0-100) needs to occur to be certain a change beyond measurement error has occurred in an individual patient.

Tasks of activities of daily living (ADL) are more valuable than the classical neurological examination to assess upper extremity function and mobility in multiple sclerosis

“…In our study, we found a lower correlation between the 9HPT and AMSQ ( r = 0.44–0.61) than in another study ( r = 0.77). 16 This supports the idea that different constructs were tested with the 9HPT and AMSQ. This is in line with our finding that combinations of movements explained different proportions of the variances of the 9HPT and AMSQ.…”

Minimal clinically important difference of improvement on the Arm Function in Multiple Sclerosis Questionnaire (AMSQ)

“…2 The AMSQ is a unidimensional 31-item questionnaire with good psychometric properties. 3 However, a minimal clinically important difference (MCID) has not been reported yet. An MCID defines the smallest amount of change on a scale that is important or meaningful to a patient.…”

Differential item functioning of the Arm function in Multiple Sclerosis Questionnaire (AMSQ) by language, a study in six countries

“…In an earlier study, the construct validity, test-retest reliability, and measurement error of the AMSQ were tested and were found sufficient. 16 As most studies in MS, either epidemiological studies or treatment trials, are performed in a multicenter international setting, outcome measures need to be available in all languages of the participating countries in trials. To that end, the AMSQ was translated into English, German, Spanish, French, and Italian.…”

“…In an earlier study, the construct validity, test–retest reliability, and measurement error of the AMSQ were tested and were found sufficient. 16…”