Measurement of the Respiratory Volumes of Laboratory Animals

Guyton, Arthur C.

doi:10.1152/ajplegacy.1947.150.1.70

Cited by 559 publications

(237 citation statements)

References 2 publications

(3 reference statements)

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“…These values were obtained from the equation of Guyton (1947) relating ventilation to body mass. Also input into the dosimetry computer code were the airway geometry (determined in this study) and a range of unit density (1 g/cm 3 ) particle diameters.…”

Section: Methodsmentioning

confidence: 99%

Dosimetry implications of upper tracheobronchial airway anatomy in two mouse varieties

Oldham

Phalen

2002

Anat. Rec.

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Strain-and variety-related differences in responses of mice have been reported for a variety of inhaled particulate and gaseous materials. It is important to understand the potential contributions to such responses of differences in delivered doses to the respiratory tract as well as differences in biochemical processes. Deposition doses of inhaled particles are influenced by several factors, including airway anatomy, ventilation, and particle characteristics. Tracheobronchial airway morphometry for airway generations 1-6 of the BALB/c mouse was generated using replica lung casts prepared in situ. Measurements were performed on two groups: control and ovalbumin-sensitized male BALB/c mice. These measurements were compared with previously published airway morphometry of male B6C3F 1 mice. Sensitization did not significantly change measured airway dimensions in the BALB/c mouse. However, the two mouse varieties had significant differences in airway anatomy. The differences found in airway anatomy between mouse varieties correlated with differences in body length and chest circumference. Particle deposition predictions for both varieties of mice were performed for unit density spherical particles from 0.1 to 10 m in diameter at two ventilation rates using a published aerosol dosimetry computer code. Particle deposition in the proximal tracheobronchial tree ranged up to 3 times greater for the BALB/c mouse for a 2 m particle diameter and high ventilation rate. These differences in predicted particle deposition suggest that observed strain and variety differences in response to inhaled particulate matter may be in part due to differences in delivered doses to the respiratory tract. Anat Rec 268: 59 -65, 2002.

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Section: Methodsmentioning

confidence: 99%

Dosimetry implications of upper tracheobronchial airway anatomy in two mouse varieties

Oldham

Phalen

2002

Anat. Rec.

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“…Because it is difficult to evaluate Stokes number owing to uncertainty of a and V, nasal deposition is usually expressed as a function of particle inertia d :~, where Q is the volumetric flow rate. For animal species, Q can be calculated by using the following formula proposed by Guyton (1947):…”

Section: Derivation Of Empirical Deposition Equationsmentioning

confidence: 99%

Empirical Equations for Nasal Deposition of Inhaled Particles in Small Laboratory Animals and Humans

Zhang

1993

Aerosol Science and Technology

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Based upon available experimental data, a set of empirical equations was derived for nasal deposition efficiency of inhaled particles in the inertial deposition range for four small laboratory animal species: the mouse, hamster, rat, and guinea pig. An equation for nasal deposition in humans was also derived in the same mathematical form to facilitate interspecies comparison. In these equations, deposition efficiency was expressed as a function of particle inertia d :~ where d , is the particle aerodynamic diameter and Q is the flow rate. Results from the empirical equations showed that nasal deposition was species dependent, and that a t the same d :~, species with smaller body weight had higher deposition efficiency. By incorporating the anatomical data of the nasal passage, the deposition equations were rewritten as a function of the product of Stokes number and the total bend angle in nasopharynx. Interspecies deposition differences were found to be greatly reduced in terms of the new variable.

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“…The volume of air inhaled by the monkey was calculated by the Guyton formula; 8 inoculation was conventional. Intravenous challenge was through the venous cannula into the right side of the heart.…”

Section: Aerosol Exposure Techniquementioning

confidence: 99%