Measurement of the eutectic composition and temperature of energetic materials. Part 1. The phase diagram of binary systems

Liu, Ziru; Shao, Ying-Hui; Yin, Cui-Mei; Kong, Yali

doi:10.1016/0040-6031(94)01975-m

Cited by 24 publications

(18 citation statements)

References 5 publications

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“…The simple phase diagram of menthol and camphor eutectic system was demonstrated as temperature of endothermic peak and amount of menthol in eutectic as previously reported (4). The eutectic point is the ratio in which a single melting point of liquid eutectic is obtained, and this melting point is the eutectic temperature, but when other two melting points are obtained, the first one is the eutectic temperature and the second is the melting peak of excess solid eutectic compound (24).…”

Section: Phase Diagram Of M/c Eutectic Systemsupporting

confidence: 64%

Evaporation Behavior and Characterization of Eutectic Solvent and Ibuprofen Eutectic Solution

2015

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Liquid eutectic system of menthol and camphor has been reported as solvent and co-solvent for some drug delivery systems. However, surprisingly, the phase diagram of menthol-camphor eutectic has not been reported previously. The evaporation behavior, physicochemical, and thermal properties of this liquid eutectic and ibuprofen eutectic solution were characterized in this study. Differential scanning calorimetry (DSC) analysis indicated that a eutectic point of this system was near to 1:1 menthol/camphor and its eutectic temperature was -1°C. The solubility of ibuprofen in this eutectic was 282.11 ± 6.67 mg mL(-1) and increased the drug aqueous solubility fourfold. The shift of wave number from Fourier transform infrared spectroscopy (FTIR) indicated the hydrogen bonding of each compound in eutectic mixture. The weight loss from thermogravimetric analysis of menthol and camphor related to the evaporation and sublimation, respectively. Menthol demonstrated a lower apparent sublimation rate than camphor, and the evaporation rate of eutectic solvent was lower than the sublimation rate of camphor but higher than the evaporation of menthol. The evaporation rate of the ibuprofen eutectic solution was lower than that of the eutectic solvent because ibuprofen did not sublimate. This eutectic solvent prolonged the ibuprofen release with diffusion control. Thus, the beneficial information for thermal behavior and related properties of eutectic solvent comprising menthol-camphor and ibuprofen eutectic solution was attained successfully. The rather low evaporation of eutectic mixture will be beneficial for investigation and tracking the mechanism of transformation from nanoemulsion into nanosuspension in the further study using eutectic as oil phase.

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Section: Phase Diagram Of M/c Eutectic Systemsupporting

confidence: 64%

Evaporation Behavior and Characterization of Eutectic Solvent and Ibuprofen Eutectic Solution

2015

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“…The only other compound for which data have been reported in the literature for the enthalpy of fusion is NTO. The two reported values, 27 kJ/mol [30] and 92.8 kJ/mol [31], are markedly different. The group contribution method provided an estimate of 20.17 kJ/mol.…”

Section: Group Contribution Methodsmentioning

confidence: 68%

Prediction of physicochemical properties of energetic materials

Toghiani

Maloney

et al. 2008

Fluid Phase Equilibria

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“…In these equations, A is solute, B is solvent; T is the liquidus melting temperature of the mixture (K); R is the gas constant 1.987 cal/(K mol); X is the mole fraction of A or B; ΔH fus is the heat of fusion of A or B; and T m is the melting temperature of pure A or B. 14,11 Eutectic mixtures have a decreased melting point from either of the pure compounds from which they are composed. 24 Eutectics can be used to decrease melting point, in some cases taking two solids and creating a liquid, 25 undesirable properties, e.g., hygroscopisity.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Eutectics of explosives have been investigated in several studies over the years. − In the 1930s Urbanski studied a number of energetic eutectics, including some with ETN. − His work can be found in the original Polish or partially translated in his book and in the Encyclopedia of Explosives (Table ). Chapman used published eutectic ratios for 74 binary energetic materials to create a trend line.…”

Section: Introductionmentioning

confidence: 99%

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Eutectics of Erythritol Tetranitrate

2017

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With the recent availability of erythritol as an artificial sweetener, the synthesis of erythritol tetranitrate (ETN) has become economically feasible. This paper examines the eutectics of ETN, to see if it can be a useful component in melt-casted explosive formulations. To this end, we report several novel ETN–energetic eutectics, correct ratios, and melt-temperature for a previously reported eutectic, and we examine a new eutectic composed of insensitive explosives.

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Measurement of the eutectic composition and temperature of energetic materials. Part 1. The phase diagram of binary systems

Cited by 24 publications

References 5 publications

Evaporation Behavior and Characterization of Eutectic Solvent and Ibuprofen Eutectic Solution

Evaporation Behavior and Characterization of Eutectic Solvent and Ibuprofen Eutectic Solution

Prediction of physicochemical properties of energetic materials

Eutectics of Erythritol Tetranitrate

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