Measurement of Terbium Isotopes Yield in Irradiation of 151Eu Targets by 3He Nuclei

Zagryadskii, V. A.; Latushkin, S. T.; Malamut, T. Yu.; Новиков, В. И.; Ogloblin, A. A.; Унежев, В. Н.; Chuvilin, D. Yu.

doi:10.1007/s10512-017-0299-8

Cited by 11 publications

(9 citation statements)

References 4 publications

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“…2a) are in good agreement with obtained in 21 . The saturation yield was 125.0 ± 25.0 MBq/μA for the range 70 → 40 MeV for the target from Eu 2 O 3 21 and 161.7 ± 32.3 MBq/μA in this work, recalculated for the same target. Besides terbium isotopes, peaks of 147,149 Gd were also detected in the gamma-ray spectra of irradiated targets.…”

Section: Discussionsupporting

confidence: 91%

“…Our yields based on the experimentally cross sections ( Fig. 2a) are in good agreement with obtained in 21 . The saturation yield was 125.0 ± 25.0 MBq/μA for the range 70 → 40 MeV for the target from Eu 2 O 3 21 and 161.7 ± 32.3 MBq/μA in this work, recalculated for the same target.…”

Section: Discussionsupporting

confidence: 89%

“…The physical yield of the 151 Eu( 3 He,5n) 149 Tb reaction in the range 70 → 30 MeV was 38.7 ± 7.7 MBq/μAh, that allows one to produce up to 230 MBq/μA on a 151 Eu metal target up on saturation. In previous work 21 , thick targets from pressed 151 Eu oxide were irradiated. Our yields based on the experimentally cross sections ( Fig.…”

Section: Discussionmentioning

confidence: 99%

“…As a result, 25 MBq of radionuclide had been obtained at the time of radiolabeling. It was proposed 21 to obtain 149 Tb by irradiation of 151 Eu targets with 3 He nuclei and the thick target yields in the energy range 70 → 40 MeV were experimentally determined. Preliminary results showed that 149 Tb yields can be high enough to produce therapeutic amounts of a radionuclide.…”

mentioning

confidence: 99%

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Cross section measurements of 151Eu(3He,5n) reaction: new opportunities for medical alpha emitter 149Tb production

Moiseeva

Алиев

Унежев

et al. 2020

Sci Rep

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Method for production of alpha emitter 149 tb by irradiation of 151 Eu with 70 MeV 3 He nuclei is proposed. For the first time, the cross sections for the formation of isotopes 149,150,151,152 Tb were measured experimentally using a stack foil technique in the 3 He particles energy range 70 → 12 MeV. The thick target yield of 149 Tb is 39 MBq/μAh, or 230 MBq/μA 149 tb at saturation. the optimal energy range from the point of view of radioisotopic purity is 70 → 40 MeV. At these conditions about 150 MBq/μA 149 Tb can be produced in 8 hours irradiation, which is sufficient for therapeutic applications. The main impurities are 150 Tb (~100% in activity) and 151 Tb (~30% in activity). The proposed method surpasses its counterparts by the high content of the target isotope in the natural mixture and the simplicity of the radiochemical separation of 149 tb from the bulk target material.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Cross section measurements of 151Eu(3He,5n) reaction: new opportunities for medical alpha emitter 149Tb production

Moiseeva

Алиев

Унежев

et al. 2020

Sci Rep

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“…8 151 Eu( 3 He, 5n) 149 TbCyclotron40–70 MeVZagryadskii et al . 14 152 TbTa(p,sp) 152 TbSynchrotron1.4 GeV (CERN)Allen et al . 8 155 Gd(p,4n) 152 TbCyclotron39 MeVSteyn et al .…”

Section: Introductionmentioning

confidence: 99%

Chemical Purification of Terbium-155 from Pseudo-Isobaric Impurities in a Mass Separated Source Produced at CERN

Webster

Ivanov

Russell

et al. 2019

Sci Rep

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Four terbium radioisotopes ( 149, 152, 155, 161 Tb) constitute a potential theranostic quartet for cancer treatment but require any derived radiopharmaceutical to be essentially free of impurities. Terbium-155 prepared by proton irradiation and on-line mass separation at the CERN-ISOLDE and CERN-MEDICIS facilities contains radioactive 139 Ce 16 O and also zinc or gold, depending on the catcher foil used. A method using ion-exchange and extraction chromatography resins in two column separation steps has been developed to isolate 155 Tb with a chemical yield of ≥95% and radionuclidic purity ≥99.9%. Conversion of terbium into a form suitable for chelation to targeting molecules in diagnostic nuclear medicine is presented. The resulting 155 Tb preparations are suitable for the determination of absolute activity, SPECT phantom imaging studies and pre-clinical trials.

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A heavy-ion production channel of 149Tb via 63Cu bombardment of 89Y

Wilkinson

Barrett

Ferran

et al. 2021

Applied Radiation and Isotopes

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Measurement of Terbium Isotopes Yield in Irradiation of 151Eu Targets by 3He Nuclei

Cited by 11 publications

References 4 publications

Cross section measurements of 151Eu(3He,5n) reaction: new opportunities for medical alpha emitter 149Tb production

Cross section measurements of 151Eu(3He,5n) reaction: new opportunities for medical alpha emitter 149Tb production

Chemical Purification of Terbium-155 from Pseudo-Isobaric Impurities in a Mass Separated Source Produced at CERN

A heavy-ion production channel of 149Tb via 63Cu bombardment of 89Y

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