Chemical Purification of Terbium-155 from Pseudo-Isobaric Impurities in a Mass Separated Source Produced at CERN

Webster, B.; Ivanov, P.; Russell, Ben; Collins, S.M.; Stora, T.; Ramos, J.P.; Köster, U.; Robinson, Andrew; Read, David

doi:10.1038/s41598-019-47463-3

Cited by 29 publications

(21 citation statements)

References 22 publications

(33 reference statements)

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“…The pseudo-isobars 133 CeO + and 133 LaO + were eluted at the end. A similar study on the chemical separation of155 Tb from pseudo-isobaric 139 Ce16 O was reported by Webster et al(61). In this study, sodium bromate was used to oxidize Ce(II) to Ce(IV).…”

supporting

confidence: 63%

Theranostic Terbium Radioisotopes: Challenges in Production for Clinical Application

Naskar

Lahiri

2021

Front. Med.

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Currently, research on terbium has gained a momentum owing to its four short-lived radioisotopes, 149Tb, 152Tb, 155Tb, and 161Tb, all of which can be considered in one or another field of nuclear medicine. The members of this emerging quadruplet family have appealing nuclear characteristics and have the potential to do justice to the proposed theory of theranostics nuclear medicine, which amalgamates therapeutic and diagnostic radioisotopes together. The main challenge for in vivo use of these radioisotopes is to produce them in sufficient quantity. This review discusses that, at present, neither light charged particle nor the heavy ion (HI) activation are suitable for large-scale production of neutron deficient terbium nuclides. Three technological factors like (i) enrichment of stable isotopes to a considerable level, (ii) non-availability of higher energies in commercial cyclotrons, and (iii) non-availability of the isotope separation technique coupled with commercial accelerators limit the large scale production of terbium radionuclides by light charged particle activation. If in future, the technology can overcome these hurdles, then the light charged particle activation of enriched targets would produce a high amount of useful terbium radionuclides. On the other hand, to date, the spallation reaction coupled with an online isotope separator has been found suitable for such a requirement, which has been adopted by the CERN MEDICIS programme. The therapeutic 161Tb radionuclide can be produced in a reactor by neutron bombardment on enriched 160Gd target to produce 161Gd which subsequently decays to 161Tb. The radiochemical separation is mandatory even if the ISOL technique is used to obtain high radioisotopic purity of the desired radioisotope.

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confidence: 63%

Theranostic Terbium Radioisotopes: Challenges in Production for Clinical Application

Naskar

Lahiri

2021

Front. Med.

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“…The same concern exists for other stable (e.g. 139 La 16 O, 155 Gd) or radioactive ( 155 Eu) impurities [11]. Similar conditions were observed for the shorter-lived isotope 149 Tb, also produced at ISOLDE, where isobaric contaminants 149 Eu and 133 Ce 16 O are limiting the sample purity [12].…”

Section: Introductionmentioning

confidence: 64%

First laser ions at the CERN-MEDICIS facility

et al. 2020

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The CERN-MEDICIS facility aims to produce emerging medical radionuclides for the theranostics approach in nuclear medicine with mass separation of ion beams. To enhance the radioisotope yield and purity of collected samples, the resonance ionization laser ion source MELISSA was constructed, and provided the first laser ions at the facility in 2019. Several operational tests were accomplished to investigate its performance in preparation for the upcoming production of terbium radioisotopes, which are of particular interest for medical applications.

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“…Lanthanides are represented, as many of their easily accessible chemically similar -and thus interchangeableradioisotopes constitute versatile agents for diagnostics and therapy. The purification of SPECT isotope 155 Tb (5.3 d) is featured 29 , and a method for the production and recovery of the theranostic pair 132,135 La (4.8 h and 19.5 h) with initial imaging and biodistribution evaluation is reported 30 . Alpha emitter 225 Ac (10.0 d) has emerged as a TAT isotope: one contribution looks into the in-vivo redistribution of 225 Ac daughter isotopes in a mouse model 31 ; another study reports the purification of accelerator produced 225 Ac using a silicotitanate sorbent 32 .…”

Section: Collection Overviewmentioning

confidence: 99%

Guest Edited Collection: Radioisotopes and radiochemistry in health science

Fassbender

2020

Sci Rep

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Radioisotopes can be produced artificially from stable nuclei through the interaction with particles or highly energetic photons. In combination with modern detection and counting techniques, radioisotopes and radiochemical methods uniquely contribute to the health sciences. This Collection showcases salient aspects of medical radioisotope science ranging from the production, recovery and purification of radioisotopes to the methods used to attach them to biomolecules. The Collection also presents studies that highlight the importance of radiochemistry in the assessment of environmental radioactivity.

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Chemical Purification of Terbium-155 from Pseudo-Isobaric Impurities in a Mass Separated Source Produced at CERN

Cited by 29 publications

References 22 publications

Theranostic Terbium Radioisotopes: Challenges in Production for Clinical Application

Theranostic Terbium Radioisotopes: Challenges in Production for Clinical Application

First laser ions at the CERN-MEDICIS facility

Guest Edited Collection: Radioisotopes and radiochemistry in health science

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