Abstract:Radioisotopes can be produced artificially from stable nuclei through the interaction with particles or highly energetic photons. In combination with modern detection and counting techniques, radioisotopes and radiochemical methods uniquely contribute to the health sciences. This Collection showcases salient aspects of medical radioisotope science ranging from the production, recovery and purification of radioisotopes to the methods used to attach them to biomolecules. The Collection also presents studies that… Show more
“…In contrast, copper-64 and zirconium-89 constitute radiometals with supplemental alternative decay pathways, requiring higher administration doses because of lower sensitivity. Additionally, both radionuclides have much longer half-lives (12.7 h for copper-64 [ 55 ]; 78.4 h for zirconium-89 [ 56 ]), rendering them less appropriate for nanobody radio imaging. This also applies to the gamma-emitting radiometals indium-111 and lutetium-177, which possess a half-life of 67.2 h [ 57 ] and 6.65 days [ 58 ], respectively.…”
Section: Radiolabeling Strategies Of Nanobodiesmentioning
Nanobodies are small recombinant antigen-binding fragments derived from camelid heavy-chain only antibodies. Due to their compact structure, pharmacokinetics of nanobodies are favorable compared to full-size antibodies, allowing rapid accumulation to their targets after intravenous administration, while unbound molecules are quickly cleared from the circulation. In consequence, high signal-to-background ratios can be achieved, rendering radiolabeled nanobodies high-potential candidates for imaging applications in oncology, immunology and specific diseases, for instance in the cardiovascular system. In this review, a comprehensive overview of central aspects of nanobody functionalization and radiolabeling strategies is provided.
“…Radioisotopes are critical resources for a plethora of applications, including radiopharmaceuticals, industrial radiography, powering deep-space exploration, and neutron sources. 1 The isotope 252 Cf is used as a neutron source for nuclear reactor start-up, neutron activation analysis, and oil field exploration. 2 This 252 Cf is produced at Oak Ridge National Laboratory by irradiating 249 Bk with neutrons in the High Flux Isotope Reactor, after which the targets are processed to separate the 252 Cf, as well as other isotopes, and recover the remaining 249 Bk for further use.…”
Section: Introductionmentioning
confidence: 99%
“…Radioisotopes are critical resources for a plethora of applications, including radiopharmaceuticals, industrial radiography, powering deep-space exploration, and neutron sources . The isotope 252 Cf is used as a neutron source for nuclear reactor start-up, neutron activation analysis, and oil field exploration .…”
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