Measurement of systolic time intervals.

Kelman, Andrew W.; Sumner, D. J.; Lawrence,; Whiting, B.

doi:10.1111/j.1365-2125.1978.tb00886.x

Cited by 8 publications

(6 citation statements)

References 7 publications

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“…Fairly marked LVET changes occurred after the adminis-tration of placebo ointment. Such marked STI changes have been reported after placebo in other studies (Kelman et al, 1978;Kelman et al, 1980). They presumably represent both diurnal variation and the effect of food.…”

Section: Resultssupporting

confidence: 78%

The effect of glyceryl trinitrate ointment on heart rate–corrected systolic time intervals in angina pectoris.

Struthers¹,

Whiting²,

Hillis³

et al. 1982

Brit J Clinical Pharma

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1 Individual systolic time intervals (STI) v heart rate regression equations were determined using small doses of intravenous atropine in seven patients with angina pectoris. 2 Regression lines of the form LEVT = A+B.HR and QS2 = C + D.HR were calculated. There was no significant correlation between PEP and HR. The values of parameters A C and D were significantly different from a group of previously studied normal volunteers. 3 STI changes were recorded for 5 h after the application of GTN or placebo ointment. The active drug caused shortening of LVET and QS2 with the peak effect occurring between 105 and 180 min. After 180 min neither LVET nor QS% were significantly shortened. There was no significant effect on PEP or heart rate.

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Section: Resultssupporting

confidence: 78%

The effect of glyceryl trinitrate ointment on heart rate–corrected systolic time intervals in angina pectoris.

Struthers¹,

Whiting²,

Hillis³

et al. 1982

Brit J Clinical Pharma

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“…Previous work on ouabain kinetics is scarce, but Lahrtz, Reinold & van Zwieten (1969) found a half-life of approximately 50h, and Selden & Smith (1972), a half-life of only 22h, both in groups of normal volunteers. Selden & Smith (1972) also found the 'physiological half-life' to be approximately 21 h, but this was based on STI measurements at rest using Weissler's et al (1968) corrections, a technique which the present authors have questioned previously (Kelman et al, 1978). One point that may be significant is that both Lahrtz et al (1969) and Selden & Smith (1972) sampled only up to 48h and this may have given a falsely low reading of the half life.…”

Section: Ouabainmentioning

confidence: 73%

“…However, results obtained in this laboratory from experiments adhering to a similar resting, supine protocol, indicated that the effects measured following intravenous doses of several cardiac glycosides could be reproduced following placebo injection (Kelman, Sumner, Lawrence & Whiting, 1978). This was interpreted as indicating that heart rate corrections derived from data obtained in a large group of normal subjects were inappropriate when applied to individual subjects.…”

Section: Introductionmentioning

confidence: 97%

Comparative pharmacokinetics and pharmacodynamics of cardiac glycosides.

Kelman¹,

Sumner²,

Lonsdale³

et al. 1980

Brit J Clinical Pharma

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1 The pharmacokinetics and pharmacodynamics of ouabain, digoxin and fl-methyl digoxin (medigoxin) have been investigated in a crossover study in four normal healthy volunteers.2 Pharmacokinetics were studied using [3H]-labelled glycosides and the shortening of the left ventricular ejection time (LVET) was used as a measure of the effect of the drugs. A graded exercise protocol was used to correct for the effects of heart rate on LVET.3 In three of the four subjects, both digoxin and fl-methyl digoxin produced a shortening in the LVET, but no such change could be detected with ouabain in any of the four subjects. 4 There was a good linear correlation between the shortening of the LVET and the amounts of digoxin or fl-methyl digoxin present in the body tissues.5 One subject who showed no drug-related LVET shortening had greatly enhanced clearances of all three drugs studied.

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“…The principles that have been previously outlined for the analysis of the STIs, LVET, QS2 and PEP should be equally applicable to QT intervals (Kelman et al, 1978(Kelman et al, , 1981a(Kelman et al, , 1981b. The conclusion of our work indicates that no global correction factor is adequate whether this be Bazett's correction for QTs (Bazett, 1920) or Weissler's for the STIs (Weissler et al, 1968), and that attempts must always be made to correct for heart rate on an individual basis.…”

Section: Correction Equation For Ecg Time Intervalsmentioning

confidence: 74%