Correction equation for ECG time intervals [letter]

Kelman, Andrew W.; Whiting, B.; Summer, DJ

doi:10.1111/j.1365-2125.1984.tb05036.x

Cited by 6 publications

(1 citation statement)

References 6 publications

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“…Although the ECG was recorded at a paper speed of 25 mm s-i, which is not ideal, it should nevertheless be sufficiently sensitive to detect changes in QRS or QT intervals. The use of the Bazett formula for the correction of the QT interval has been discussed recently (Staniforth, 1983;Kelman et al, 1984), and it is probable that this formula may not be the most appropriate one to use under all circumstances. In the After 636 ± 142 60 ± 14 370 ± 74t 465 ± 59**t * = P < 0.05, ** = P < 0.01 when compared to placebo.…”

Section: Discussionmentioning

confidence: 99%

Indoramin‐prolongation of repolarization time, a mechanism of bradycardia in man?

Harron¹,

Nicholls²,

Shanks³

1985

Brit J Clinical Pharma

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The effect of indoramin, a selective acr-adrenoceptor antagonist, on ECG time intervals in normal man was studied. Significant prolongation of QTc was observed after indoramin 100 mg, with no change in QRS duration. In addition, the slope of the RR/QT relationship was changed by indoramin 100 mg. These results suggest that indoramin may have Class III antiarrhythmic activity. If such activity were to affect the SA node, it may explain at least in part the observed lack of reflex tachycardia after indoramin administration.

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Section: Discussionmentioning

confidence: 99%

Indoramin‐prolongation of repolarization time, a mechanism of bradycardia in man?

Harron¹,

Nicholls²,

Shanks³

1985

Brit J Clinical Pharma

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R

Albinus

Amschler

Amschler³

et al. 1994

Hagers Handbuch Der Pharmazeutischen Praxis

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Uncorrected pre-ejection period: A simple non-invasive measurement for pharmacodynamic screening of inotropic activity

Rousson

Galleyrand

Silie

et al. 1987

Eur J Clin Pharmacol

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Since heart rate (HR) is an important determinant of the duration of systole, systolic time intervals (STI) from 8 healthy subjects were examined after infusion of atropine. As no overall correlation was found between HR and pre-ejection period (PEP), the results confirm the need for individual estimates of the correction of the left ventricular ejection time (LVET) and the total electromechanical systole (OS2). In the same subjects the sensitivity of PEP to minor negative inotropic effects of mexiletine and disopyramide measured at Cmax was confirmed. Thus, in addition to its simplicity and reliability, the sensitivity of the uncorrected PEP should encourage use of this technique as part of any screening system for the early detection of an inotropic effect of new chemical entities.

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Correction equation for ECG time intervals [letter]

Cited by 6 publications

References 6 publications

Indoramin‐prolongation of repolarization time, a mechanism of bradycardia in man?

Indoramin‐prolongation of repolarization time, a mechanism of bradycardia in man?

R

Uncorrected pre-ejection period: A simple non-invasive measurement for pharmacodynamic screening of inotropic activity

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