Measurement of Surface Color and Color Difference of Tablet Colorants by Tristimulus Colorimetry

Bogdansky, Frances M.

doi:10.1002/jps.2600640230

Cited by 16 publications

(6 citation statements)

References 16 publications

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“…Thus, a more quantitative measure of color uniformity is desired in order to prevent failures on release, failures on stability, or customer complaints for the duration that the product is marketed. As early as 1975, Bogdansky28 reported that tristimulus colorimetry was a valuable and quantitative tool to differentiate small differences between coated tablets that allowed for quality control specifications to be established by applying limits to chromaticity coordinates (i.e., a and b in the Hunter color space). Recently, Garcia‐Munoz and Gierer29 described a multivariate color image analysis technique that was used to determine the cosmetic endpoint of the color‐coating process.…”

Section: Resultsmentioning

confidence: 99%

Integrating Tristimulus Colorimetry into Pharmaceutical Development for Color Selection and Physical Appearance Control: A Quality-by-Design Approach

Hetrick

Vannoy

Montgomery

et al. 2013

Journal of Pharmaceutical Sciences

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Section: Resultsmentioning

confidence: 99%

Integrating Tristimulus Colorimetry into Pharmaceutical Development for Color Selection and Physical Appearance Control: A Quality-by-Design Approach

Hetrick

Vannoy

Montgomery

et al. 2013

Journal of Pharmaceutical Sciences

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“…25 Microcapsules and microspheres of cross-linked collagen, gelatin, and albumin have been used for drug delivery. 26 The synthetic ability to manipulate amino acid sequences has developed extensively over the last two decades with new techniques and strategies continually being introduced.…”

Section: Polymersmentioning

confidence: 99%

Biodegradable polymers: An update

Shikanov

Kumar

Domb

2005

Israel Journal of Chemistry

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The use of polymeric materials for the administration of pharmaceuticals, and as biomedical devices has increased dramatically. This review focuses on synthetic biodegradable polymers of current interest for medical use, based on ester and anhydride bonds. Special attention is given to factors affecting biodegradation, including: polymer structure, morphology, molecular weight, radiation, and chemical treatment, as well as the effects of drugs and plasticizers added to the polymer mass. The toxicity and biocompatibility of the polymers and their current and future applications in medicine are also briefly reviewed.

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“…The color of pharmaceutical tablets is a key aspect of their visual aspect;hence, the need to control its evolution during the coating process. It is known that tablets' color has a significant influence on the expectations, emotions, and preferences of the consumers, while being an indirect indicator of the tablet's functional condition.…”

Section: Introductionmentioning

confidence: 99%

Color evolution during a coating process of pharmaceutical tablet cores by random spraying

Murillo

Rodríguez-Pulido

Heredia

et al. 2018

Color Research & Application

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Placebo white tablet cores (lactose anhydrous [47.6%], corn starch [23.8%], microcrystalline cellulose [19.1%], polyvinylpyrrolidone [7.9%], magnesium stearate [0.8%], and talcum powder [0.8%]) were coated with a colorant (hydroxypropyl methylcellulose [8% w/v], titanium dioxide [0.2% w/v], FD&C yellow No. 6 with aluminum lacquer [0.8% w/v], polyethylene glycol 4000 [0.4% w/v], and purified water [q.s.p. 100 mL]) using a random spraying method during 130 minutes. During the coating process, batches of 21 samples were extracted every 10 minutes and measured with a DigiEye imaging system. The initial cores showed very similar and uniform colors (Mean Color Difference from the Mean [MCDM] of 0.8 CIELAB units), but partially coated tablets showed lower uniformity (MCDM below 2.0 CIELAB units). There was a high color variability (MCDM about 4.0 CIELAB units) among tablets of the same batch in the period between 10 and 30 minutes, which decreased as the coating process progressed, until achieving a final acceptable value (MCDM below 2.0 CIELAB units). During the coating process, L* decreased, C*ab strongly increased, and h ab remained nearly constant (disregarding results at 0 and 10 minutes). CIELAB and CIEDE2000 color differences (mainly chroma differences) with respect to the initial color of the tablets were modeled as a function of time by exponential functions with three coefficients. The color change in the interval from 90 to 130 minutes (4.3 CIELAB units, or 2.6 CIEDE2000 units), may be considered negligible bearing in mind the color variability in the batches of 21 samples and typical values of visual color thresholds.

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Measurement of Surface Color and Color Difference of Tablet Colorants by Tristimulus Colorimetry

Cited by 16 publications

References 16 publications

Integrating Tristimulus Colorimetry into Pharmaceutical Development for Color Selection and Physical Appearance Control: A Quality-by-Design Approach

Integrating Tristimulus Colorimetry into Pharmaceutical Development for Color Selection and Physical Appearance Control: A Quality-by-Design Approach

Biodegradable polymers: An update

Color evolution during a coating process of pharmaceutical tablet cores by random spraying

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