Measurement of serum paraoxonase activity and MDA concentrations in patients suffering with oral squamous cell carcinoma

Malik, Uzma; Siddiqui, Imtiaz Ather; Hashim, Zehra; Zarina, Shamshad

doi:10.1016/j.cca.2013.12.033

Cited by 38 publications

(28 citation statements)

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“…Due to the preventive effect of oxidative stress, scientists report the HDL‐associated PON1 levels may act as a potential marker in cancer. For instance, several studies demonstrated that serum PON1 activity is lower in patients with lung , pancreatic , gastric , gastroesophageal , prostate , epithelial ovarian cancer , and oral squamous cell carcinoma when compared to the control groups.…”

Section: Resultsmentioning

confidence: 99%

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Some Anticancer Agents Act on Human Serum Paraoxonase‐1 to Reduce Its Activity

Alım

Beydemır

2016

Chem Biol Drug Des

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Human serum paraoxonase (hPON1) is an important antioxidant enzyme. It protects low-density lipoproteins against oxidative stress and prevents atherosclerosis development. Anticancer agents have cardiotoxic effects, and this situation can lead to significant complications. Our aim was to evaluate the in vitro effects of some of the anticancer agents such as cetuximab, paclitaxel, etoposide, docetaxel, and ifosfamide on the activity of hPON1 in this study. For this reason, PON1 was purified from human serum with a specific activity of 3654.2 EU/mg and 16.84% yield using simple chromatographic methods. The five chemotherapeutic agents dose dependently decreased in vitro hPON1 activity. IC50 values for cetuximab, paclitaxel, etoposide, docetaxel, and ifosfamide were 0.0111, 0.042, 0.226, 0.665, and 23.3 mm, respectively. Ki constants were 0.0194, 0.0165, 0.131, 0.291, and 8.973 mm, respectively. The inhibition mechanisms of cetuximab, etoposide, docetaxel, and ifosfamide were non-competitive, and for paclitaxel was competitive. Consequently, inhibition of hPON1 by these anticancer agents may explain some of the cardiotoxic actions of these drugs.

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Section: Resultsmentioning

confidence: 99%

“…For instance, Malik et al . report that the role of oxidative imbalance in the oral squamous cell carcinoma may be associated with the antioxidant status. Thus, ‘PON levels may act as an indicator of oxidative stress in cancer’.…”

mentioning

confidence: 99%

Some Anticancer Agents Act on Human Serum Paraoxonase‐1 to Reduce Its Activity

Alım

Beydemır

2016

Chem Biol Drug Des

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“…MDA is the intermediate product of cellular lipid peroxides and extensively studied as a potential biomarker for oxidative stress (Malik et al . ). The result in Fig.…”

Section: Resultsmentioning

confidence: 97%

“…SOD is an important enzyme, which exhibits antioxidant activity to prevent free radicals from damaging normal genetic material and inducing cancer. MDA is the intermediate product of cellular lipid peroxides and extensively studied as a potential biomarker for oxidative stress (Malik et al 2014). The result in Fig.…”

Section: Antioxidant Activity Of the P Eryngii Extract In Vivomentioning

confidence: 98%

Antitumor and Immunomodulatory Activity of P leurotus eryngii Extract

Xue

Zhai

et al. 2014

Journal of Food Biochemistry

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Pleurotus eryngii (P. eryngii), also known as the king oyster mushroom, contains many bioactive substances, including polysaccharides, lipids, peptides, sterols and triterpenoids. The aim of this study was to explore the antitumor and immunomodulatory activities of P. eryngii extract. The fresh P. eryngii material was extracted with MeOH (methanol) and then partitioned with EtOAc (ethyl acetate). The study showed that the P. eryngii EtOAc extract (EAe) not only has antitumor effects by in vitro and in vivo methods but also significantly increases some immune activities. In addition, histopathological observations showed that EAe‐treated mice exhibited much lower cancerization throughout the liver and lung. EAe can also promote antioxidant activity, which may regulate the body's antioxidant capacity and activate the antitumor mechanism. Practical Applications Our study revealed the anticancer and immunomodulatory activity of Pleurotus eryngii extract, and identified the key components of the P. eryngii extract with HPLC‐MS. These findings explain the antitumor activity of P. eryngii, which is very useful for developing the potential antitumor drugs for clinical application.

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“…La PON1 est capable d'empê-cher la peroxydation des lipides et hydrolyse les phospholipides oxydés, participant à l'action anti-oxydante des HDL sur les lipoprotéines de basse densité (LDL) ; ces derniers ont un rôle important dans l'initiation des pathologies vasculaires comme l'athérosclérose [5]. Des études ont montré que la PON1 pourrait contribuer à d'autres fonctions liées aux HDL, intervenant dans l'immunité innée, la prévention d'une infection bactérienne, le développement du cancer [6][7][8], ainsi que les maladies psychiatriques [9,10]. Le diabète type 1 (DT1) est l'endocrinopathie la plus fréquente chez l'enfant.…”

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