La paraoxonase 1 : un marqueur de risque cardiovasculaire chez les jeunes diabétiques de type 1 ? (109 cas)

Paraoxonase 1 polymorphisms (L55M and Q192R) as a genetic marker of diabetic nephropathy in youth with type 1 diabetes

“…Paraoxonase 1 (PON1) is an HDL-associated lipolactonase preventing LDL and cell membrane oxidation, and is therefore considered to be atheroprotective [3,4]. Thus, lower PON1 activity was observed in high oxidative stress diseases such as coronary heart disease, dyslipidaemia, inflammatory processes, and diabetes [5][6][7][8], and it has also been linked to kidney disease [1,9,10]. Furthermore, it has been reported that diabetic microangiopathy is genetically heterogeneous [11] and that oxidative stress pathway genes might be an important predictor for the development of diabetic complications [12].…”