Measurement of serum hyaluronic acid level during the perioperative period of liver resection for evaluation of functional liver reserve

Nanashima, Atsushi; Yamaguchi, Hiroyuki; Shibasaki, Susumu; Sawai, Terumitsu; Yamaguchi, Eiichiro; Yasutake, Toru; Tsuji, Takashi; Jibiki, Masaaki; Nakagoe, Tohru; Ayabe, Hiroyoshi

doi:10.1046/j.1440-1746.2001.02599.x

Cited by 28 publications

(44 citation statements)

References 26 publications

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“…In two cases, Tc-GSA liver scintigraphy is useful in cases with discrepant data. In the future, a comprehensive risk score or classification for postoperative morbidity using various hepatic functional parameters is necessary, as indicated in previous reports (32,33 Tc-GSA uptake, in which functional volume was decreased in comparison with the morphological volume, as in our pilot study (17)(18)(19)21,22). In such cases, the indications for major hepatectomy might be suitable to decide markedly reduced functional volume.…”

Section: Patient Demographicsmentioning

confidence: 61%

“…Essentially, planned hepatectomy was performed if the permitted resected volume of the liver was greater than the estimated resected volume of the liver. When the permitted resected volume was less than the estimated volume, preoperative PVE was performed according to our criterion (17,18 Tc-GSA scintigraphy, as well as serum hyaluronic acid level, was also examined preoperatively, along with ICGR15 and other functional liver parameters (21,22). LHL15 was calculated from the dynamic image and defined as the ratio of uptake by the liver alone to that of uptake by the liver and heart at 15 min (23).…”

Section: Evaluation Of Liver Function For Hepatectomymentioning

confidence: 99%

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Usefulness of examining hepatic functional volume using technetium-99m galactosyl serum albumin scintigraphy in hepatocellular carcinoma

Nanashima¹,

Abo²,

Kudo

et al. 2013

Nuclear Medicine Communications

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ObjectivesThe aim of the study was to clarify the clinical significance of single-photon emission computed tomography/computed tomography (SPECT/CT) imaging in terms of technetium-99m galactosyl human serum albumin ( 99m Tc-GSA) scintigraphy. To this end, we examined the relationship using data from surgical records of 67 patients with hepatocellular carcinoma who underwent hepatectomy. Materials and methodsLiver functional parameters or functional volume was estimated by 99m Tc-GSA scintigraphy and computed tomography volumetry was used to estimate morphological volume. ResultsLiver uptake ratio at 15 min (LHL15) was correlated with the indocyanine green retention rate at 15 min (ICGR15; R=−0.608, P<0.01); however, five patients (7.5%) had values outside this correlation.In these patients, LHL15 reflected clinical status and patient outcomes more. Although morphological and functional volumes were well correlated (P<0.01), functional volume was decreased in the diseased liver with portal vein tumor thrombus or portal vein embolization. By applying ConclusionUnder the ICGR15 test as the standard for preoperative hepatic function, auxiliary application of LHL15 and functional volumetry provides useful information on hepatocellular carcinoma patients undergoing hepatectomy.

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Section: Patient Demographicsmentioning

confidence: 61%

Section: Evaluation Of Liver Function For Hepatectomymentioning

confidence: 99%

Usefulness of examining hepatic functional volume using technetium-99m galactosyl serum albumin scintigraphy in hepatocellular carcinoma

Nanashima¹,

Abo²,

Kudo

et al. 2013

Nuclear Medicine Communications

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“…Therefore, other reliable functional parameters were needed. Recently, novel tests of FLR, such asserum HA level (13)(14)(15), GSA scintigraphy (16), and interleukin levels (17), have been used to evaluate post hepatectomy complications. Furthermore, correlation of LHL15 and HH15 to ICGR15 using a linear regression model and the analysis of individual liver segments by dynamic SPECT are easy and convenient methods for predicting FLR by GSA scintigraphy (18 -21).…”

Section: Discussionmentioning

confidence: 99%

Treatment strategy for successful hepatic resection of icteric liver

et al. 2018

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: Background : The treatment strategy for jaundiced patients with hilar cholangiocarcinoma (HC) is not well established. In this study, we evaluate the feasibility of our perioperative protocol for jaundiced patients with HC. Methods : Twenty patients with HC who underwent hepatic resection at our institute were enrolled, and patients were divided into icteric(n=6) and normal(n=14) group. As a perioperative protocol, Oral administration of Inchinkoto(ICKT), steroid and nafamostat mesilate were introduced. The evaluation of functional future remnant liver(FRL) by asiaroscintigraphy, and postoperative outcomes were retrospectively compared. Results : Indocyanine green dye retention rate at 15 minutes was higher, and LHL15 values was lower in icteric group. However, in the functional evaluation of FRL, which was the sum of GSA uptake of the future FRL, there was no significant difference of LHL15 values of the remnant liver functional reserve between the two groups. As results, according to the difference of liver function, serum AST level was not different between two groups. The number of patients with postoperative morbidity in the two groups was comparable. Conclusions : Even in HC patients with icteric liver, accurate assessment of liver functional reserve and effective perioperative treatment may attribute to successful hepatectomy and favorable post-operative outcomes.

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“…In 1996, our group started to analyze 99m Tc-GSA scintigraphy preoperatively and, since 2004, a combination of ICGR15, GSA scintigraphy and measurement of serum hyaluronic acid has been applied for operative indication on the basis of retrospective analysis for 8 years (9,11,19). As a result, the postoperative morbidity has been improved recently (data has been submitted).…”

Section: In Tests Of 99mmentioning

confidence: 99%

Usefulness of measuring hepatic functional volume using technetium-99m galactosyl serum albumin scintigraphy in hilar bile duct carcinoma

Nanashima

Tobinaga

Abo

et al. 2010

Clin J Gastroenterol

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Measurement of serum hyaluronic acid level during the perioperative period of liver resection for evaluation of functional liver reserve

Abstract: Our results indicate that the measurement of the HA level is useful for monitoring liver damage or predicting complications associated with liver surgery.

Cited by 28 publications

References 26 publications

Usefulness of examining hepatic functional volume using technetium-99m galactosyl serum albumin scintigraphy in hepatocellular carcinoma

Usefulness of examining hepatic functional volume using technetium-99m galactosyl serum albumin scintigraphy in hepatocellular carcinoma

Treatment strategy for successful hepatic resection of icteric liver

Usefulness of measuring hepatic functional volume using technetium-99m galactosyl serum albumin scintigraphy in hilar bile duct carcinoma

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