Usefulness of measuring hepatic functional volume using technetium-99m galactosyl serum albumin scintigraphy in hilar bile duct carcinoma

Background The aim was to evaluate the value of 99mTc-labeled galactosyl human serum albumin (99mTc-GSA) with single-photon emission computerized tomography (SPECT) in the preoperative assessment of regional liver function and prediction of posthepatectomy liver failure (PHLF) in patients with hilar cholangiocarcinoma (hCCA). Methods Patients with hCCA who underwent 99mTc-GSA SPECT/computed tomography (CT) before hepatectomy were included. The liver functional parameters of functional liver density (FLD) and predictive residual index (PRI) were calculated based on 99mTc-GSA SPECT/CT. PHLF was defined according to the International Study Group of Liver Surgery criteria. Univariate and multivariate analyses were used to analyze the risk factors for PHLF. The prediction of PHLF was calculated using receiver operating characteristic curve. Results A total of 34 patients were included, 23 of whom underwent preoperative biliary drainage. FLD was significantly higher in patients with drained lobes than that in patients with undrained lobes (0.615 ± 0.190 versus 0.500 ± 0.211, P < 0.05). Sixteen patients suffered PHLF. The ratio of future remnant to total morphological liver volume, future remnant FLD, and PRI differed significantly in patients with and without PHLF according to univariate analysis. PRI was identified as the only independent factor for prediction of PHLF according to multivariate analysis. With a PRI of 0.78, it was possible to predict PHLF with a sensitivity of 83% and a specificity of 93%. Conclusions 99mTc-GSA SPECT/CT can accurately assess regional liver function and is better able to predict PHLF than conventional methods in patients with hCCA.

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The value of 99mTc-labeled galactosyl human serum albumin single-photon emission computerized tomography/computed tomography on regional liver function assessment and posthepatectomy failure prediction in patients with hilar cholangiocarcinoma

Huang

Chen

Shao

et al. 2020

Nuclear Medicine Communications

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Evaluation of Accuracy for Quantitative Predictor of Hepatic Functional Reserve Using Planar and SPECT Images in the <sup>99m</sup>Tc-GSA Scintigraphy

Hasegawa

Onishi

2017

Nippon Hoshasen Gijutsu Gakkai Zasshi

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緒言99m Tc-肝受容体シンチグラフィによる定量評価法は，一般的にプレイナ画像の正面像によるダイナミック収集から算出した clearance index(uptake ratio of the heart at 15 minutes to that at 3 minutes: HH15)と receptor index (uptake ratio of the liver to the liver plus heart at 15 minutes: LHL15)の 2 種類の指標が用 SummaryPurpose: The purpose of this study was to evaluate the accuracy for quantitative predictor of hepatic functional reserve using planar and single photon emission computed tomography (SPECT) images. Methods: We acquired planar and SPECT images of the myocardial torso phantom and calculated LHL (uptake ratio of the liver to the liver plus heart). Planar images were used with and without scatter correction. Myocardial torso phantom was simulated radioactivity distribution of normal liver function and poor liver function. This study compared the LHLplanar (calculated by planar images) and the LHLSPECT (calculated by SPECT images) with the true value (calculated by radioactivity concentration in the phantom) and evaluated the error rate. Results: Error rate of LHLSPECT was improved compared with the LHLplanar. The error rate of LHLplanar (with scatter correction) was increased in the poor liver function than in the normal liver function. Conclusions: The SPECT images have higher advantage to predict the liver function than the planar images.

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Usefulness of measuring hepatic functional volume using technetium-99m galactosyl serum albumin scintigraphy in hilar bile duct carcinoma

Cited by 2 publications

References 19 publications

The value of 99mTc-labeled galactosyl human serum albumin single-photon emission computerized tomography/computed tomography on regional liver function assessment and posthepatectomy failure prediction in patients with hilar cholangiocarcinoma

The value of 99mTc-labeled galactosyl human serum albumin single-photon emission computerized tomography/computed tomography on regional liver function assessment and posthepatectomy failure prediction in patients with hilar cholangiocarcinoma

Evaluation of Accuracy for Quantitative Predictor of Hepatic Functional Reserve Using Planar and SPECT Images in the <sup>99m</sup>Tc-GSA Scintigraphy

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