Measurement of retinal nerve fiber layer and macular ganglion cell–inner plexiform layer with spectral-domain optical coherence tomography in patients with optic nerve head drusen

Casado, Alfonso; Rebolleda, Gema; Guerrero, Laura K.; Leal, Marina; Contreras, Inés; Oblanca, Noelia; Muñoz‐Negrete, Francisco J.

doi:10.1007/s00417-014-2773-5

Cited by 49 publications

(33 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We also show that ONH drusen is associated with changes to RGC dendrites, cell bodies and the unmyelinated portion of RGC axons. The latter findings have previously been demonstrated using optical coherence tomography . Collectively, the findings of our study suggest that disc drusen induces alterations to all four compartments of the RGC, similar to glaucoma.…”

supporting

confidence: 88%

Retrobulbar axonal degeneration due to optic disc drusen

Chan

Morgan

et al. 2018

Clinical Exper Ophthalmology

View full text Add to dashboard Cite

supporting

confidence: 88%

Retrobulbar axonal degeneration due to optic disc drusen

Chan

Morgan

et al. 2018

Clinical Exper Ophthalmology

View full text Add to dashboard Cite

“…A study by Casado et al (2014) found macular RNFL decrease in patients with ODD when compared to control subjects. The study further found a higher percentage of abnormal thinning associated with more crowded discs.…”

Section: Oct-measured Rnfl Thicknessmentioning

confidence: 97%

Optic disc drusen: understanding an old problem from a new perspective

Hamann

Malmqvist

Costello

2018

Acta Ophthalmologica

101

106

View full text Add to dashboard Cite

Optic disc drusen (ODD) are acellular deposits located in the optic nerve head of up to 2.4% of the population. They may develop as by-products of impaired axonal metabolism in genetically predisposed individuals, in whom a narrow scleral canal is hypothesized to play a role. Although ODD are often considered as benign innocent bystanders, recognized as part of a routine ophthalmological examination, the vast majority of patients with ODD have visual field defects. Optic disc drusen (ODD)-associated complications with severe visual loss, most often due to anterior ischaemic optic neuropathy, are also known to occur. There are no treatments available to prevent or ameliorate the vision loss caused by ODD. In children, the ODD are usually uncalcified and buried within the optic nerve head tissue. In these cases, the condition can be difficult to diagnose, as it often resembles a papilloedema with optic nerve head swelling caused by raised intracranial pressure. During the teenage years, the ODD progressively become more calcified and probably also larger, which allow them to be visible on ophthalmoscopy. With the advent and proper utilization of high-resolution modalities of optical coherence tomography (OCT), it has now become possible to detect even the smallest and most deeply located ODD. This allows for ODD detection at a much earlier developmental stage than has previously been possible and enhances the possibilities of research in underlying mechanisms. A review of the literature on ODD was conducted using the PUBMED database. The review focuses on the current knowledge regarding pathogenesis, diagnostics, clinical disease-tracking methodologies, structure-function relationships and treatment strategies of ODD.

show abstract

“…62 A new OCT parameter, macular ganglion cell-inner plexiform layer (GCIPL) thickness, may show thinning earlier than the RNFL in buried optic disc drusen in both children and adults. 25; 163 Some authors have sought to use OCT RNFL thickness to distinguish between optic disc drusen and true disc edema, in which RNFL thickness may be higher, especially nasally; 11; 88; 181 however, the degree of RNFL thickening in true disc edema may depend on the severity of edema, and thickness may not differ significantly between mild optic disc edema and pseudopapilledema. 92 …”

Section: Diagnostic Testingmentioning

confidence: 99%

Optic disk drusen in children

Chang

Pineles

2016

Survey of Ophthalmology

112

View full text Add to dashboard Cite

Optic disc drusen occur in 0.4% of children and consist of acellular intracellular and extracellular deposits that often become calcified over time. They are typically buried early in life and generally become superficial, and therefore visible, later in childhood, at the average age of 12 years. Their main clinical significance lies in the ability of optic disc drusen, particularly when buried, to simulate true optic disc edema. Misdiagnosing drusen as true disc edema may lead to an invasive and unnecessary workup for elevated intracranial pressure. Ancillary testing, including ultrasonography, fluorescein angiography, fundus autofluorescence, and optical coherence tomography, may aid in the correct diagnosis of optic disc drusen. Complications of optic disc drusen in children include visual field defects, hemorrhages, choroidal neovascular membrane, non-arteritic anterior ischemic optic neuropathy, and retinal vascular occlusions. Treatment options for these complications include ocular hypotensive agents for visual field defects and intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents for choroidal neovascular membranes. In most cases, however, children with optic disc drusen can be managed by observation with serial examinations and visual field testing, once true optic disc edema has been excluded.

show abstract

Measurement of retinal nerve fiber layer and macular ganglion cell–inner plexiform layer with spectral-domain optical coherence tomography in patients with optic nerve head drusen

Cited by 49 publications

References 32 publications

Retrobulbar axonal degeneration due to optic disc drusen

Retrobulbar axonal degeneration due to optic disc drusen

Optic disc drusen: understanding an old problem from a new perspective

Optic disk drusen in children

Contact Info

Product

Resources

About