Retrobulbar axonal degeneration due to optic disc drusen

Chan, Gerald; Morgan, William H.; Yu, Dao‐Yi; Balaratnasingam, Chandrakumar

doi:10.1111/ceo.13137

Cited by 1 publication

(2 citation statements)

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“…Like glaucoma, ODD can be viewed as a neurodegenerative disorder in which damage to retinal ganglion cells and axons in the afferent visual pathway leads to progressive vision loss over time (Chan et al 2017;Costello 2017;Gramer et al 2017). Efforts are ongoing to establish a structural-functional paradigm that identifies glaucoma patients at risk of vision loss, early in their chronic disease course.…”

Section: Future Perspectivesmentioning

confidence: 99%

“…Efforts are ongoing to establish a structural-functional paradigm that identifies glaucoma patients at risk of vision loss, early in their chronic disease course. Like glaucoma, ODD can be viewed as a neurodegenerative disorder in which damage to retinal ganglion cells and axons in the afferent visual pathway leads to progressive vision loss over time (Chan et al 2017;Costello 2017;Gramer et al 2017). The assessment of structuralfunctional correlations in ODD are likewise highly important; these relationships may reflect the effects of chronic mechanical stress on axons and might provide information on the risk of ODD-related complications that further imperil visual function in these patients.…”

Section: Future Perspectivesmentioning

confidence: 99%

See 1 more Smart Citation

Optic disc drusen: understanding an old problem from a new perspective

Hamann

Malmqvist

Costello

2018

Acta Ophthalmologica

101

106

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Optic disc drusen (ODD) are acellular deposits located in the optic nerve head of up to 2.4% of the population. They may develop as by-products of impaired axonal metabolism in genetically predisposed individuals, in whom a narrow scleral canal is hypothesized to play a role. Although ODD are often considered as benign innocent bystanders, recognized as part of a routine ophthalmological examination, the vast majority of patients with ODD have visual field defects. Optic disc drusen (ODD)-associated complications with severe visual loss, most often due to anterior ischaemic optic neuropathy, are also known to occur. There are no treatments available to prevent or ameliorate the vision loss caused by ODD. In children, the ODD are usually uncalcified and buried within the optic nerve head tissue. In these cases, the condition can be difficult to diagnose, as it often resembles a papilloedema with optic nerve head swelling caused by raised intracranial pressure. During the teenage years, the ODD progressively become more calcified and probably also larger, which allow them to be visible on ophthalmoscopy. With the advent and proper utilization of high-resolution modalities of optical coherence tomography (OCT), it has now become possible to detect even the smallest and most deeply located ODD. This allows for ODD detection at a much earlier developmental stage than has previously been possible and enhances the possibilities of research in underlying mechanisms. A review of the literature on ODD was conducted using the PUBMED database. The review focuses on the current knowledge regarding pathogenesis, diagnostics, clinical disease-tracking methodologies, structure-function relationships and treatment strategies of ODD.

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Section: Future Perspectivesmentioning

confidence: 99%

Section: Future Perspectivesmentioning

confidence: 99%